No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
50 – 80
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Prevention
Participants needed
12 (estimated)
Sponsor
Pravat Mandal · Other
Who this trial is looking for
This trial is looking for people with early Parkinson's disease to see how a supplement called gamma-glutamylcysteine affects their health. Participants will take the supplement and have their brain, blood, and gut health checked over time.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's disease.
I have a MoCA score of 26 or higher.
I am between 50 and 80 years old.
I can read and write in English.
You may not be able to join if
I have a pacemaker or other implants in my body.
I have a history of cancer.
I have had a head injury in the past.
I have active psychosis or delirium.
I have chronic kidney or liver disease.
I have Parkinson's disease dementia.
I am taking antioxidant therapies.
I have claustrophobia.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate:
1. To study the enrichment of master antioxidant, glutathione (GSH) levels in brain and blood of these PD patients compared to baseline due to GGC supplementation.
2. To study the changes in motor function, cognitive skills in P…
This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate:
1. To study the enrichment of master antioxidant, glutathione (GSH) levels in brain and blood of these PD patients compared to baseline due to GGC supplementation.
2. To study the changes in motor function, cognitive skills in PD patients due to GGC oral supplementation
3. To study impact of GGC on gut health on the PD patients.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Confirmed Parkinson's Disease diagnosis.
* Montreal Cognitive Assessment (MoCA) greater than or equal to 26.
* Age (50 to 80 years of age).
* Ability to read and write in English.
Exclusion Criteria:
* Presence of pacemakers, aneurysm clips, artificial heart valves, ear impl…
Inclusion Criteria:
* Confirmed Parkinson's Disease diagnosis.
* Montreal Cognitive Assessment (MoCA) greater than or equal to 26.
* Age (50 to 80 years of age).
* Ability to read and write in English.
Exclusion Criteria:
* Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the eyes, skin, or body.
* Subjects with claustrophobia.
* Patients with a clinical diagnosis of Parkinson's disease dementia or dementia with Lewy bodies.
* Subjects with a history of cancer.
* Subjects with active psychosis or delirium.
* Subjects with chronic kidney (creatinine \> 1.5mg/dL) or liver disease (AST ≥ 1.5 ULN; ALT ≥ 1.5 ULN) within 30 days prior to enrolment.
* Subjects on antioxidant therapy (ashwagandha, gingko biloba or N-acetylcysteine) or illicit drug abuse/dependence (cocaine, heroin, marijuana, or fentanyl).
* Subjects with previous traumatic head injury.
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