Parkinson's Trials / Trials in Missouri
10 Recruiting Trials

Clinical Trials
for Parkinson's in Missouri

10 clinical trials for Parkinson's are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

10
Recruiting trials
9
Study sites
2
Cities
3
Industry-sponsored
1
Phase 2
2
Phase 3

Parkinson's clinical trials in Missouri: what to expect

Parkinson's trials fall into three groups. Disease-modifying studies test drugs meant to slow progression, including treatments aimed at alpha-synuclein, repurposed diabetes drugs and therapies for people with LRRK2 or GBA gene variants. Symptom studies test new ways to smooth out "off" periods and dyskinesia, and procedures such as focused ultrasound and deep brain stimulation. And a large number of studies involve no medicine: exercise, speech and balance programs, wearables, and long-term observational studies that track the disease.

In Missouri, recruiting parkinson's studies are concentrated in St Louis and Chesterfield. 3 of the 10 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Parkinson's trials usually look for

Disease-modifying trials usually enroll people diagnosed in the last two to five years, sometimes before any Parkinson's medicine has started. Symptom trials want people on levodopa who have a stated number of hours of "off" time a day. Most set ages 30 to 80, exclude dementia and atypical parkinsonism, and may require a dopamine transporter scan to confirm the diagnosis. Genetic trials test for the variant at no cost. Exercise and observational studies accept a much wider range.

What taking part involves

Screening includes a movement exam, sometimes performed both before and after your morning dose, blood work and a scan. Drug trials run twelve weeks to two years with monthly visits, symptom diaries and, in some, a spinal fluid test. Placebo arms are common and medicines you already take generally continue. Exercise and rehabilitation trials involve sessions two or three times a week for several months. Everything study-related is free and travel is usually reimbursed; a care partner is welcome and sometimes required.

Questions worth asking the study team

Whether you must skip a dose before visits; whether your current medicines continue; what the chance of placebo is and whether an extension follows; how many visits are required; and whether you will be told the results of any scans or genetic tests.

Showing 10 of 10 recruiting Parkinson's trials in Missouri

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
PHASE3 Birmingham, Alabama +4 sites NCT07174310
This trial is looking for people with early-stage Parkinson's disease who are currently on stable treatment with levodopa. Participants will receive either the drug prasinezumab or a placebo to study its effects.
Recruiting
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
PHASE4 Tucson, Arizona +4 sites NCT04373317
This trial is looking for veterans aged 40 or older who have Parkinson's disease and experience symptoms like hallucinations or delusions. Participants will take either Pimavanserin or Quetiapine, and will need to attend study visits regularly.
Recruiting
Neuroimaging of Parkinson's
N/A St Louis, Missouri NCT07024875
This trial is looking for people diagnosed with Parkinson's Disease or healthy individuals without family history of the condition. Participants will undergo brain imaging to help researchers understand changes in brain connectivity related to Parkinson's.
Recruiting
Investigations of Dementia in Parkinson Disease
N/A St Louis, Missouri NCT02763683
This trial is looking for people with Parkinson's disease who may be at risk of developing dementia. Participants will undergo brain imaging to help understand different types of dementia in these patients.
Recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
N/A Aliso Viejo, California +4 sites NCT02071134
This trial is looking for adults with Parkinson’s disease to evaluate a device called the Vercise DBS System. Participants will help gather information on the device's effectiveness in treating their condition.
Recruiting
A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease
NA St Louis, Missouri +2 sites NCT07705373
This trial is looking for people with Parkinson's disease who can walk independently and are willing to try a new walking program that uses music to help improve their walking. Participants will join for about 18 weeks and will have four visits at research centers.
Recruiting
A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease
PHASE2 Birmingham, Alabama +4 sites NCT06976268
This trial is looking for adults aged 40 to 80 with early Parkinson's disease. Participants will receive treatment over 48 weeks, followed by another 48 weeks of open access to the treatment.
Recruiting
Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease
NA St Louis, Missouri NCT06859528
This trial is looking for people aged 30 to 85 with Parkinson's disease. Participants will join a walking group once a week for six months and will use special walking poles. The program aims to help them connect with others and increase their physical activity.
Recruiting
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
N/A Birmingham, Alabama +4 sites NCT06719583
This trial is looking for Black and African American individuals to help understand Parkinson's disease. Participants will share their experiences and may provide saliva samples for research.
Recruiting
Clinical Outcomes for Deep Brain Stimulation
N/A St Louis, Missouri NCT03992625
This trial is looking for patients who have specific movement disorders. Participants will receive deep brain stimulation treatment while we track their outcomes, risks, and benefits over time.
Recruiting
See all 10 Parkinson's trials in Missouri

Where the Parkinson's studies are in Missouri

Research sites running the most studies
  • Washington University in St. Louis, St Louis2 trials
  • East Imaging Building, St Louis1 trial
  • Integrated Health and Movement Science Laboratory, Saint Louis University, St Louis1 trial
  • Site-044, Chesterfield1 trial
  • St. Louis University Hospital, St Louis1 trial
  • St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis1 trial
By city

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

Parkinson's clinical trials in Missouri: common questions

How many Parkinson's clinical trials are recruiting in Missouri?
TrialFinder currently lists 10 recruiting Parkinson's clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Parkinson's clinical trials located in Missouri?
Study sites for the Parkinson's trials listed on this page include St Louis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Parkinson's clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Parkinson's trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Parkinson's clinical trial in Missouri?
Each study sets its own criteria based on age, Parkinson's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a Parkinson's trial if I take carbidopa-levodopa?
Yes for most trials, including every study of "off" time. Some disease-modifying trials want people who have not started medicine yet; the listing says so.
What does "off time" mean in a trial listing?
The hours each day when your medicine has worn off and symptoms return. Trials of new symptom treatments usually require about two or more hours of off time a day, recorded in a diary during screening.
Are there Parkinson's trials that do not involve medicine?
Many. Exercise, speech, balance and dance programs, wearable sensors, deep brain stimulation settings and observational studies all recruit, and most accept people at any stage who can attend sessions.
Parkinson's Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Parkinson's Trials

Parkinson's disease trials test dopamine-replacement therapies, deep brain stimulation, gene therapies, and neuroprotective compounds to slow disease progression.

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