Stroke Trials / Trials in Missouri
27 Recruiting Trials

Clinical Trials
for Stroke in Missouri

27 clinical trials for Stroke are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

27
Recruiting trials
23
Study sites
6
Cities
7
Industry-sponsored
3
Phase 2
6
Phase 3

Stroke clinical trials in Missouri: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In Missouri, recruiting stroke studies are concentrated in St Louis, Columbia, Kansas City and Bridgeton, with sites in 2 other cities. 7 of the 27 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 27 recruiting Stroke trials in Missouri

Improving Participation After Stroke Self-Management-Rehabilitation
NA Columbia, Missouri NCT06588647
This trial is looking for people who have had a stroke within the last 6 months. Participants will join small group sessions online to help improve their daily activities and overall quality of life.
Recruiting
Compass 3: A Novel Transition Program to Reduce Disability After Stroke
NA Columbia, Missouri +1 sites NCT07069660
This trial is looking for people who have recently had a stroke and are moving from rehabilitation to home. Participants will either learn about stroke recovery or make changes to their home environment to support their recovery.
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Birmingham, Alabama +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Birmingham, Alabama +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Mobile, Alabama +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
PHASE2 Long Beach, California +4 sites NCT06990867
This trial is looking for adults with acute ischemic stroke who seek care within 4.5 to 24 hours. Participants will receive either a new treatment called JX10 or a placebo to see how it affects recovery and safety.
Recruiting
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
PHASE3 Tucson, Arizona +4 sites NCT05691244
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a new treatment called sovateltide along with standard care and will be monitored for safety and effectiveness.
Recruiting
Strategy for Improving Stroke Treatment Response
PHASE2 Birmingham, Alabama +4 sites NCT05948566
This trial is looking for adults who have had a suspected ischemic stroke. Participants will receive a treatment called TS23 to see how safe and effective it is within a specific time after their stroke.
Recruiting
Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)
PHASE2 Scottsdale, Arizona +4 sites NCT06226805
This trial is looking for adults who have had an acute ischemic stroke within the last 24 hours. Participants will receive either the study drug or a placebo and will be monitored for 90 days.
Recruiting
The Pivotal Study of RapidPulseTM Aspiration System
NA Torrance, California +4 sites NCT06029491
This trial is looking for adults aged 18 to 80 who have had a stroke within the last 8 hours. Participants will receive a treatment to remove a blood clot in the brain and will be monitored for 90 days.
Recruiting
StrokeNet Thrombectomy Endovascular Platform
NA Birmingham, Alabama +4 sites NCT06289985
This trial is looking for people who have had a suspected ischemic stroke due to a blockage in a large or medium blood vessel in the brain. Participants will be assessed to determine if they can receive a treatment called endovascular thrombectomy.
Recruiting
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
N/A Birmingham, Alabama +4 sites NCT05907629
This trial is looking for people who have recently had a stroke caused by narrowing of blood vessels in the brain. Participants will undergo an MRI to help researchers learn more about treatment options for this condition.
Recruiting
The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms
NA Phoenix, Arizona +4 sites NCT07143019
This trial is looking for adults with specific types of brain aneurysms who are interested in trying a new device treatment. Participants will need to agree to follow study procedures and provide consent.
Recruiting
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
NA Birmingham, Alabama +4 sites NCT06870812
This trial is looking for adults with a specific type of brain bleed to compare surgery with standard medical care. Participants will receive either surgery to remove blood from the brain or regular medical treatment.
Recruiting
Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well
NA St Louis, Missouri +4 sites NCT07115940
This trial is looking for adults who have had a stroke and are between 24 and 72 hours after their symptoms began. Participants will receive a specific stroke treatment along with regular medical care to see if it improves their recovery.
Recruiting
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
NA St Louis, Missouri NCT07404852
Recruiting
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
PHASE3 Birmingham, Alabama +4 sites NCT07227246
This trial is looking for adults who have experienced a type of stroke called intracerebral hemorrhage. Participants may receive a treatment called rFVIIa within a specific time frame to see if it improves their recovery.
Recruiting
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
PHASE3 Birmingham, Alabama +4 sites NCT03907046
This trial is looking for adults who have had a recent brain bleed and have atrial fibrillation. Participants will compare the effects of a medication called apixaban with aspirin to see which better prevents strokes or death.
Recruiting
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
PHASE3 Little Rock, Arkansas +4 sites NCT04045665
This trial is looking for patients who develop new atrial fibrillation after heart bypass surgery. Participants will receive a treatment to help prevent blood clots while monitoring their safety and health.
Recruiting
Portable MRI for Pediatric Hypoxic Ischemic Brain Injury
NA Kansas City, Missouri NCT07577336
This trial is looking for children aged 0-17 who might have brain injuries due to lack of oxygen. Participants will receive a portable MRI to help doctors understand their condition better.
Recruiting
See all 27 Stroke trials in Missouri

Where the Stroke studies are in Missouri

Research sites running the most studies
  • Barnes Jewish Hospital, St Louis5 trials
  • University of Missouri, Columbia4 trials
  • Washington University in St. Louis, St Louis4 trials
  • Washington University School of Medicine, St Louis2 trials
  • Barnes Jewish Hospital, Saint Loius1 trial
  • Barnes-Jewish Hospital, St Louis1 trial
By city

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in Missouri: common questions

How many Stroke clinical trials are recruiting in Missouri?
TrialFinder currently lists 27 recruiting Stroke clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in Missouri?
Study sites for the Stroke trials listed on this page include Columbia, St Louis, Kansas City. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in Missouri?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
Stroke Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Stroke Trials

Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

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