Stroke Trials / Trials in North Carolina
32 Recruiting Trials

Clinical Trials
for Stroke in North Carolina

32 clinical trials for Stroke are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.

32
Recruiting trials
30
Study sites
12
Cities
10
Industry-sponsored
4
Phase 2
6
Phase 3

Stroke clinical trials in North Carolina: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In North Carolina, recruiting stroke studies are concentrated in Durham, Charlotte, Winston-Salem and Raleigh, with sites in 8 other cities. 10 of the 32 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 32 recruiting Stroke trials in North Carolina

Xeomin® and Gait Related Mobility After Stroke
PHASE4 Charlotte, North Carolina NCT04908423
This trial is looking for adults who have difficulty walking after a stroke. Participants will receive an injection of Xeomin® in their arms and will be tested on their walking ability before and about a month later.
Recruiting
Telerehabilitation In The Home After Stroke
NA Downey, California +4 sites NCT06682429
This trial is looking for people who have arm weakness from a stroke that happened 90 to 150 days ago. Participants will receive telerehabilitation to improve their arm function, alongside usual care, for 6 weeks.
Recruiting
Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization
NA Durham, North Carolina NCT07220005
This trial is looking for adults who have had a stroke and still have weakness in one arm. Participants will receive treatments using low-intensity ultrasound to see if it helps with their motor skills.
Recruiting
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
NA Durham, North Carolina +1 sites NCT07050355
This trial is looking for adults who have experienced a stroke and are dealing with depression. Participants will combine aerobic exercise with a non-invasive brain stimulation treatment to see if it helps improve their mood and walking ability.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA Tucson, Arizona +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.
NA Durham, North Carolina NCT06765642
This trial is looking for people who have had their first stroke at least 3 months ago and have weakness in one arm. Participants will receive a brain stimulation treatment to see if it helps improve their hand muscle function.
Recruiting
Modulation of Brain Rhythms in Stroke
NA Chapel Hill, North Carolina NCT07121582
This trial is looking for people who have had a stroke and have weakness in one arm. Participants will take part in a session that lasts about 3 hours, where they will receive brain stimulation while squeezing a hand grip to see if it helps improve their strength and function.
Recruiting
FOA on Sit to Stand in Individuals Post Chronic Stroke
NA Cullowhee, North Carolina NCT07460804
This trial is looking for people who had a stroke more than six months ago. Participants will learn how focusing attention differently can help them improve in standing up from a chair and walking.
Recruiting
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
N/A Birmingham, Alabama +4 sites NCT05338697
This trial is looking for adults who have had a stroke and are experiencing motor difficulties in one arm. Participants will undergo specific tests and procedures to help researchers understand recovery outcomes.
Recruiting
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
N/A Chicago, Illinois +4 sites NCT00682695
This trial is looking for adults who have had a hemorrhagic stroke. Participants will provide consent for interviews, blood pressure checks, and blood sampling.
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Birmingham, Alabama +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Mobile, Alabama +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
PHASE3 Tucson, Arizona +4 sites NCT05691244
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a new treatment called sovateltide along with standard care and will be monitored for safety and effectiveness.
Recruiting
Strategy for Improving Stroke Treatment Response
PHASE2 Birmingham, Alabama +4 sites NCT05948566
This trial is looking for adults who have had a suspected ischemic stroke. Participants will receive a treatment called TS23 to see how safe and effective it is within a specific time after their stroke.
Recruiting
Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)
PHASE2 Scottsdale, Arizona +4 sites NCT06226805
This trial is looking for adults who have had an acute ischemic stroke within the last 24 hours. Participants will receive either the study drug or a placebo and will be monitored for 90 days.
Recruiting
Allopregnanolone (Zuranolone) in Post-stroke Depression
PHASE2 Durham, North Carolina NCT06759558
This trial is looking for stroke survivors aged 21-65 who have moderate to severe depression after their stroke. Participants will take a medication called zuranolone for 14 days and complete some questionnaires.
Recruiting
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
PHASE2 Durham, North Carolina +2 sites NCT06440707
This trial is looking for people who have had an acute ischemic stroke and are not eligible for standard treatments. Participants will receive a new type of treatment involving a weak electrical current aimed at improving blood flow to the brain.
Recruiting
RIsE Stroke Mobility Study
NA Winston-Salem, North Carolina NCT07638462
Recruiting
StrokeNet Thrombectomy Endovascular Platform
NA Birmingham, Alabama +4 sites NCT06289985
This trial is looking for people who have had a suspected ischemic stroke due to a blockage in a large or medium blood vessel in the brain. Participants will be assessed to determine if they can receive a treatment called endovascular thrombectomy.
Recruiting
EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment
NA Downey, California +4 sites NCT06386874
This trial is looking for adults who have had a recent ischemic stroke. Participants will receive treatment using a wearable device and take part in exercise sessions over several months.
Recruiting
See all 32 Stroke trials in North Carolina

Where the Stroke studies are in North Carolina

Research sites running the most studies
  • Duke University Hospital, Durham6 trials
  • Carolinas Medical Center, Charlotte4 trials
  • Duke University, Durham3 trials
  • Wake Forest Baptist Medical Center, Winston-Salem3 trials
  • WakeMed, Raleigh3 trials
  • Atrium Health, Charlotte2 trials
By city

Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in North Carolina: common questions

How many Stroke clinical trials are recruiting in North Carolina?
TrialFinder currently lists 32 recruiting Stroke clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in North Carolina?
Study sites for the Stroke trials listed on this page include Charlotte, Durham, Chapel Hill, Cullowhee, Winston-Salem. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in North Carolina?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
Stroke Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Stroke Trials

Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

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