No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
45 – 80
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
20 (estimated)
Sponsor
University of North Carolina, Chapel Hill · Other
Who this trial is looking for
This trial is looking for people who have had a stroke and have weakness in one arm. Participants will take part in a session that lasts about 3 hours, where they will receive brain stimulation while squeezing a hand grip to see if it helps improve their strength and function.
Are You a Good Fit for This Trial?
Rules you outSeizure activityCognitive deficitsCerebellar stroke
You may be able to join if
I have had a stroke at least 6 months ago.
I have weakness in one arm from the stroke.
I can understand and follow instructions in English.
I can perform a grip task with my weak hand.
I have a cognitive score of 21 or higher.
I have a response in my brain function test.
You may not be able to join if
I have had a seizure in the past 2 years.
I am currently pregnant.
I have metal in my body that can't be removed.
I have a cognitive score below 21.
I am in therapy for my stroke at the same time.
I have an injury that affects how I use my arm.
I have vision problems that glasses don't fix.
I have had a cerebellar stroke.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task.
The investigators will fit participants with an electroencephalography (EEG) cap and place electromyography (EMG) stickers on pa…
The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task.
The investigators will fit participants with an electroencephalography (EEG) cap and place electromyography (EMG) stickers on participants hand and arm muscles to record brain and muscle activity, respectively.
Participants will complete a single research visit lasting approximately 3 hours. During this visit, participants will receive two different types of non-invasive brain stimulation: \[1\] stimulation to the motor part of the brain and \[2\] stimulation to the visual part of the brain. Participants will be randomized so that half will receive stimulation to the motor part of the brain first followed by stimulation to the visual part of the brain second and vice versa. Participants will complete three blocks of hand squeezing trials using the stroke-affected (weak) hand. During the first block of squeezing trials, no brain stimulation will occur. During the second and third blocks, participants will receive stimulation just before each hand squeezing trial. The investigators will record participants' brain and muscle activity during these blocks of hand squeezing trials. Additionally, participants will also complete screening tests and exams looking at mood, motor function, and cognition.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Chronic (≥ 6 months) unilateral cortical/subcortical ischemic or hemorrhagic stroke as confirmed by medical records
* Upper extremity weakness (hemiparesis) contralateral to the stroke
* Sufficient cognitive capacity (Montreal Cognitive Assessment ≥ 21 points), communication f…
Inclusion Criteria:
* Chronic (≥ 6 months) unilateral cortical/subcortical ischemic or hemorrhagic stroke as confirmed by medical records
* Upper extremity weakness (hemiparesis) contralateral to the stroke
* Sufficient cognitive capacity (Montreal Cognitive Assessment ≥ 21 points), communication function, and English proficiency to understand and safely comply with all study procedures
* Ipsilesional motor-evoked potential response
* Able to perform isometric grip task by making a fist with their stroke-affected hand (hand contralateral to the stroke)
Exclusion Criteria:
* Contraindications to TMS (seizure activity within past 2 years, pregnancy, indwelling metal)
* Cognitive deficits (Montreal Cognitive Assessment \< 21 points)
* Concurrent physical/occupational therapy and/or clinical trial participation related to stroke
* Injury or conditions that impact affected extremity-use beyond stroke (e.g., arthritis)
* Impaired vision despite use of aid (e.g. glasses, contacts, etc.)
* Cerebellar stroke
* Major medical/neurological/psychiatric condition impacting physical function in the opinion of the physician co-investigator
* Absent ipsilesional motor-evoked potential response
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