75 Recruiting Trials
Clinical Trials
for Diabetes in North Carolina
75 clinical trials for Diabetes are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
75
Recruiting trials
103
Study sites
27
Cities
48
Industry-sponsored
13
Phase 2
25
Phase 3
Diabetes clinical trials in North Carolina: what to expect
Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.
In North Carolina, recruiting diabetes studies are concentrated in Morehead City, Chapel Hill, Winston-Salem and Durham, with sites in 23 other cities. 48 of the 75 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who diabetes trials usually look for
Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.
You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.
What taking part involves
Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.
Questions worth asking the study team
Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.
Showing 20 of 75 recruiting Diabetes trials in North Carolina
Integrating New Skills Into Diabetes Education With CGM
Recruiting
This trial is looking for older adults who take insulin to learn new skills for managing diabetes. Participants will take part in educational sessions about using a continuous glucose monitor (CGM) over 6 weeks.
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
Recruiting
This trial is looking for adults with type 1 diabetes who experience high levels of diabetes-related distress. Participants will join online group sessions to learn ways to feel better about managing their diabetes.
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
Recruiting
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Recruiting
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
Recruiting
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
Recruiting
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema
Recruiting
This trial is looking for adults with type 2 diabetes who are currently stable on a specific diabetes injection. Participants will switch to a new treatment called CagriSema for about 6 months to see how well they tolerate it.
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
Recruiting
This trial is looking for people with obesity or overweight who also have type 2 diabetes. Participants will receive a weekly injection of ribupatide to see how it affects their weight and blood sugar levels.
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
Recruiting
This trial is looking for adults with type 2 diabetes and kidney problems. Participants will take either elecoglipron or a placebo while continuing their diabetes medications.
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
Recruiting
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
Recruiting
This trial is looking for adults with Type 2 Diabetes who have been managing their condition for at least three months but still need better control. They're particularly interested in those whose blood sugar levels are in a specific range and who have a body weight that meets certain guidelines. However, they’re not accepting people with certain serious health issues, like a history of severe low blood sugar or specific types of diabetes other than Type 2.
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
Recruiting
This trial is looking for children with Type 2 diabetes to test different doses of a medication called dulaglutide. Participation will last about 8 months and requires being treated with certain diabetes medications.
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin
Recruiting
This trial is looking for adults with type 2 diabetes who are already taking insulin and other medications to lower blood sugar. Participants will compare a new treatment called elecoglipron with a placebo to see how effective and safe it is.
Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy
Recruiting
This trial is looking for adults with Type 2 Diabetes who are not reaching their blood sugar goals while using Ozempic. Participants will take icovamenib to see if it helps improve their condition.
Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus
Recruiting
This trial is looking for adults with type 2 diabetes to test a new treatment called HM15275. Participants will be monitored for 36 weeks to see how well the treatment works and if it is safe.
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
Recruiting
This trial is looking for people aged 5 to 40 who have recently been diagnosed with Type 1 Diabetes. Participants will receive either the study medication or a placebo and will be monitored for safety and effectiveness.
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
Recruiting
This trial is looking for adults with type 2 diabetes who have certain blood sugar levels and are managing their condition with specific injectable medications. They should also have maintained their weight for a few months and not have serious heart issues or other specific health conditions. However, it’s important that they haven’t recently used any weight loss medications or insulin.
A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
Recruiting
This trial is looking for people with type 2 diabetes to test a new medicine called UBT251. Participants will receive either UBT251, a placebo, or another medication called semaglutide, chosen at random.
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Recruiting
This trial is looking for adults who are at least 18 years old and have type 2 diabetes that isn’t well controlled. They should have been on stable diabetes medications for a while and show signs of high cortisol levels. However, it won't include anyone who just started having diabetes, has serious low blood sugar issues, or works night shifts regularly.
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Recruiting
This trial is looking for adults with type 2 diabetes who aren't able to control their blood sugar well while taking metformin. Participants will receive either the new medication CX11 or a placebo for 24 weeks, followed by a 2-week follow-up.
Where the Diabetes studies are in North Carolina
Research sites running the most studies
- University of North Carolina at Chapel Hill, Chapel Hill9 trials
- Duke University, Durham5 trials
- Wake Forest University Health Sciences, Winston-Salem5 trials
- Carteret Medical Group, Morehead City4 trials
- Research Site, Raleigh4 trials
- Research Site, Statesville4 trials
By city
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
Diabetes clinical trials in North Carolina: common questions
How many Diabetes clinical trials are recruiting in North Carolina?
TrialFinder currently lists 75 recruiting Diabetes clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in North Carolina?
Study sites for the Diabetes trials listed on this page include Chapel Hill. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in North Carolina?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
Diabetes Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Diabetes Trials
Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.
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