26 Recruiting Trials

Clinical Trials
for Diabetes in Iowa

26 clinical trials for Diabetes are currently recruiting participants at study sites in Iowa. Study-related care is provided at no cost.

26
Recruiting trials
17
Study sites
6
Cities
15
Industry-sponsored
2
Phase 2
13
Phase 3

Diabetes clinical trials in Iowa: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Iowa, recruiting diabetes studies are concentrated in Iowa City, West Des Moines, Ames and Council Bluffs, with sites in 2 other cities. 15 of the 26 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 26 recruiting Diabetes trials in Iowa

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
PHASE3 New Haven, Connecticut +4 sites NCT07282613
This trial is looking for children and teenagers with type 2 diabetes. Participants will receive either a new medicine called CagriSema or a placebo for part of the study, and then everyone will receive CagriSema for the second part.
Recruiting
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
PHASE3 Iowa City, Iowa +4 sites NCT07222137
This trial is looking for children and adults who are at high risk for type 1 diabetes, meaning they have certain markers in their blood that suggest they might develop the condition soon. To participate, you should be at least 18 pounds in weight and not have any other types of diabetes or serious heart-related issues. They also won't be able to include anyone who has had certain serious infections or health problems.
Recruiting
Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema
PHASE3 Gilbert, Arizona +4 sites NCT07817251
This trial is looking for adults with type 2 diabetes who are currently stable on a specific diabetes injection. Participants will switch to a new treatment called CagriSema for about 6 months to see how well they tolerate it.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
PHASE3 Huntsville, Alabama +4 sites NCT07662109
This trial is looking for adults with Type 2 Diabetes who have been managing their condition for at least three months but still need better control. They're particularly interested in those whose blood sugar levels are in a specific range and who have a body weight that meets certain guidelines. However, they’re not accepting people with certain serious health issues, like a history of severe low blood sugar or specific types of diabetes other than Type 2.
Recruiting
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
PHASE3 Tucson, Arizona +4 sites NCT06739122
This trial is looking for children with Type 2 diabetes to test different doses of a medication called dulaglutide. Participation will last about 8 months and requires being treated with certain diabetes medications.
Recruiting
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
PHASE2 Chandler, Arizona +4 sites NCT07296484
This trial is looking for adults who are at least 18 years old and have type 2 diabetes that isn’t well controlled. They should have been on stable diabetes medications for a while and show signs of high cortisol levels. However, it won't include anyone who just started having diabetes, has serious low blood sugar issues, or works night shifts regularly.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting
Recruiting
IH, Brain Health, and T2D
NA Iowa City, Iowa NCT07173543
This trial is looking for older adults, with and without type 2 diabetes, to see if a treatment called intermittent hypoxia can help improve brain health. Participants will need to meet certain health criteria and complete some tests.
Recruiting
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
EARLY_PHASE1 Iowa City, Iowa NCT05917587
This trial is looking for women who have had gestational diabetes and are at least 12 weeks postpartum. Participants will be given metformin to see if it helps improve blood vessel function in these women.
Recruiting
Type 1 Diabetes Extension Study
N/A San Francisco, California +4 sites NCT02734277
This trial is looking for people who have previously participated in a type 1 diabetes study. Taking part means we will follow you to see how long you continue to produce insulin and how your immune system changes over time.
Recruiting
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NA Chandler, Arizona +4 sites NCT06112418
This trial is looking for older adults with diabetes or risk factors for heart disease. Participants will be randomly assigned to receive different types of care to see which approach is better at preventing heart problems.
Recruiting
Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
EARLY_PHASE1 Iowa City, Iowa NCT06547619
This trial is looking for women who have been pregnant in the last five years, especially those who had gestational diabetes. They should be generally healthy, but won't be able to participate if they have certain health issues like high blood pressure, liver problems, or if they're currently smoking or pregnant. It's also important that they don’t have very low body weight or any allergies to things used during the study.
Recruiting
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
PHASE3 Birmingham, Alabama +4 sites NCT07654374
This trial is looking for adults with obesity or overweight who also have type 2 diabetes. Participants will take either the drug aleniglipron or a placebo for 76 weeks to assess its effects.
Recruiting
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
PHASE3 Gilbert, Arizona +4 sites NCT07684144
This trial is looking for people with obesity and type 2 diabetes who have completed a previous study. Participants will take a medication to see how it works over a longer time period, while following specific rules during the trial.
Recruiting
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07564414
This trial is looking for people with obesity, with or without type 2 diabetes, who want to lose weight. Participants will be assigned by chance to receive either CagriSema or semaglutide for about 83 weeks.
Recruiting
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
PHASE3 Tuscaloosa, Alabama +4 sites NCT07321886
This trial is looking for adults who are overweight or have obesity but do not have type 2 diabetes. Participants will take eloralintide for a main phase lasting about 75 weeks, with an option to continue for another 2 years if they have prediabetes.
Recruiting

Where the Diabetes studies are in Iowa

  • University of Iowa, Iowa City8 trials
  • Iowa Diabetes and Endocrinology Research Center, West Des Moines4 trials
  • Iowa City VA Health Care System, Iowa City, IA, Iowa City2 trials
  • Iowa Diabetes Research, West Des Moines2 trials
  • Research Site, Ames2 trials
  • ACCOMPLISH-2 Research Site, Des Moines1 trial

Counts are recruiting studies listing at least one site in Iowa, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Iowa: common questions

How many Diabetes clinical trials are recruiting in Iowa?
TrialFinder currently lists 26 recruiting Diabetes clinical trials with study sites in Iowa. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Iowa?
Study sites for the Diabetes trials listed on this page include Iowa City. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Iowa?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Iowa also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Iowa?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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