Clinical Trials
for Kidney Disease in North Carolina
35 clinical trials for Kidney Disease are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
Kidney Disease clinical trials in North Carolina: what to expect
Kidney disease trials are mostly for chronic kidney disease that is slowly getting worse, including kidney disease caused by diabetes. They test medicines meant to slow the decline in kidney function and protect the heart, usually on top of the standard blood pressure and diabetes treatments. Specific kidney diseases such as IgA nephropathy, FSGS and polycystic kidney disease now have many trials of their own, and separate studies enroll people on dialysis or living with a transplant.
In North Carolina, recruiting kidney disease studies are concentrated in Durham, Winston-Salem, Charlotte and Chapel Hill, with sites in 19 other cities. 19 of the 35 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who kidney disease trials usually look for
Trials describe kidney disease by two numbers: the filtration rate (eGFR) from a blood test and the amount of protein in the urine. Most enroll an eGFR between about 20 and 75 and a urine protein level above a cut-off, both measured at screening. Nearly all ask that you have taken a stable dose of a blood-pressure medicine of the ACE inhibitor or ARB type for three months, and many allow or require an SGLT2 inhibitor. IgA nephropathy and FSGS trials need a past kidney biopsy. Common exclusions are a transplant, dialysis and uncontrolled blood pressure.
What taking part involves
Screening includes blood and urine tests, sometimes a 24-hour urine collection, and a review of your records. Trials then run one to three years with visits every four to twelve weeks for labs and blood pressure, taking a study pill or injection added to your usual medicines; placebo arms are common and an extension often follows. Your nephrologist keeps managing your care. Study medicine and tests are free and visits are usually paid.
Questions worth asking the study team
Which stage the trial enrolls and whether you fit it; whether any of your medicines change; how often labs are needed; the chance of placebo; and whether you will be told your own kidney results during the study.
Showing 20 of 35 recruiting Kidney Disease trials in North Carolina
Where the Kidney Disease studies are in North Carolina
- Brookview Hills Research Associates, LLC, Winston-Salem3 trials
- Duke University, Durham3 trials
- Research Site, Kinston3 trials
- Research Site, Winston-Salem3 trials
- Brookview Hills Research Associates, Winston-Salem2 trials
- Duke University Medical Center, Durham2 trials
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
Kidney Disease clinical trials in North Carolina: common questions
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