No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
65 – 100
Sex
Any
Study type
Interventional
Purpose
Supportive Care
Participants needed
30 (estimated)
Sponsor
Wake Forest University Health Sciences · Other
Who this trial is looking for
This trial is looking for older adults with chronic kidney disease who can exercise. Participants will join a 12-week program involving high-velocity resistance training or discussions about healthy living.
Are You a Good Fit for This Trial?
Rules you outType 1 diabetesInsulin dependent Type 2 diabetes
You may be able to join if
I have chronic kidney disease stages 3-5
I can complete physical exercise
I live within 20 miles of Wake Forest Reynolda Campus
I speak fluent English
I won't travel outside my area for a long time during the study
I am willing to be randomized to either group
You may not be able to join if
I am receiving or will start renal replacement therapy in the next 6 months
I am dependent on a wheelchair
I currently participate in a resistance training program
I have had joint replacement or orthopedic surgery in the last 6 months
I have absolute contraindications to exercise testing
I have Parkinson's disease
I have a respiratory disease requiring oxygen
I have active cancer requiring treatment
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an a…
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to:
1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD.
2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Chronic kidney disease stages 3-5
* Capacity to complete physical exercise
* Lives within 20 miles of Wake Forest Reynolda Campus
* Fluent English speaker
* Does not plan to travel outside of home area for an extended period of time during study
* Willing to be randomized to e…
Inclusion Criteria:
* Chronic kidney disease stages 3-5
* Capacity to complete physical exercise
* Lives within 20 miles of Wake Forest Reynolda Campus
* Fluent English speaker
* Does not plan to travel outside of home area for an extended period of time during study
* Willing to be randomized to either intervention group
Exclusion Criteria:
* Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
* Dependent on a wheelchair
* Current participation in a resistance training program
* Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months
* Absolute contraindications to exercise testing according to ACSM:
Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection
* Parkinson's disease
* Respiratory disease requiring oxygen
* Cancer requiring treatment
* Currently receiving physical therapy or cardiopulmonary rehabilitation
* Type I or insulin dependent Type II Diabetes
* Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
* Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence
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