MZE829 for APOL1 Kidney Disease

A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Recruiting Phase 2 Interventional Study
Proteinuric Kidney Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 68
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
74 (estimated)
Sponsor
Maze Therapeutics · Industry
Who this trial is looking for

This trial is looking for adults with a specific genetic risk for kidney disease and ongoing protein in their urine. Participants will take the drug MZE829 to see how it affects their kidney condition.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have the APOL1 G1/G1, G2/G2, or G1/G2 genotype.
  • I have chronic kidney disease with persistent albuminuria.

You may not be able to join if

  • I have had an organ or bone marrow transplant.
  • I have a history of active cancer in the past 2 years, except for treated non-melanoma skin cancer.
  • I have had bariatric surgery.
  • I have type 1 diabetes.
  • I am pregnant or currently nursing.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.

Trial Locations
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Eligibility Criteria
Key Inclusion Criteria: * APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2 * Chronic kidney disease with persistent albuminuria Key Exclusion Criteria: * Organ or bone marrow transplantation * History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cer…
Contacts

Maze Therapeutics

650-850-5075

APOL1info@mazetx.com

CONTACT