Kidney Disease Trials / Trials in California
47 Recruiting Trials

Clinical Trials
for Kidney Disease in California

47 clinical trials for Kidney Disease are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

47
Recruiting trials
133
Study sites
53
Cities
34
Industry-sponsored
15
Phase 2
16
Phase 3

Kidney Disease clinical trials in California: what to expect

Kidney disease trials are mostly for chronic kidney disease that is slowly getting worse, including kidney disease caused by diabetes. They test medicines meant to slow the decline in kidney function and protect the heart, usually on top of the standard blood pressure and diabetes treatments. Specific kidney diseases such as IgA nephropathy, FSGS and polycystic kidney disease now have many trials of their own, and separate studies enroll people on dialysis or living with a transplant.

In California, recruiting kidney disease studies are concentrated in Los Angeles, San Francisco, San Dimas and Concord, with sites in 49 other cities. 34 of the 47 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who kidney disease trials usually look for

Trials describe kidney disease by two numbers: the filtration rate (eGFR) from a blood test and the amount of protein in the urine. Most enroll an eGFR between about 20 and 75 and a urine protein level above a cut-off, both measured at screening. Nearly all ask that you have taken a stable dose of a blood-pressure medicine of the ACE inhibitor or ARB type for three months, and many allow or require an SGLT2 inhibitor. IgA nephropathy and FSGS trials need a past kidney biopsy. Common exclusions are a transplant, dialysis and uncontrolled blood pressure.

What taking part involves

Screening includes blood and urine tests, sometimes a 24-hour urine collection, and a review of your records. Trials then run one to three years with visits every four to twelve weeks for labs and blood pressure, taking a study pill or injection added to your usual medicines; placebo arms are common and an extension often follows. Your nephrologist keeps managing your care. Study medicine and tests are free and visits are usually paid.

Questions worth asking the study team

Which stage the trial enrolls and whether you fit it; whether any of your medicines change; how often labs are needed; the chance of placebo; and whether you will be told your own kidney results during the study.

Showing 20 of 47 recruiting Kidney Disease trials in California

A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
PHASE3 Los Angeles, California +4 sites NCT05457283
This trial is looking for children and young adults aged 1 to 18 who have chronic kidney disease and proteinuria. Participants will take a treatment called finerenone alongside their current heart medicine for about 18 months.
Recruiting
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
PHASE3 Beverly Hills, California +4 sites NCT06531824
This trial is looking for adults with chronic kidney disease who are at risk of it getting worse. Participants will take a study medicine called BI 690517 along with empagliflozin or just empagliflozin for the study duration.
Recruiting
A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)
PHASE3 Palo Alto, California +4 sites NCT07107945
This trial is looking for children aged 2 to 17 who have chronic kidney disease. Participants will take a daily tablet for 6 months followed by 1 year of another medication, with regular check-ups to monitor their health.
Recruiting
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
PHASE3 Huntsville, Alabama +4 sites NCT07753993
This trial is looking for adults with chronic kidney disease to see how well elecoglipron works compared to a placebo. Participants must be on certain medications for their condition before joining the study.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
PHASE2 San Dimas, California +4 sites NCT06717698
This trial is looking for adults with chronic kidney disease, with or without type 2 diabetes, who are living with overweight or obesity. Participants will receive either a new medicine, a standard medicine, or a placebo for up to 43 weeks.
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
PHASE1 Glendale, California +4 sites NCT07024823
This trial is looking for healthy individuals and those with chronic kidney disease and type 2 diabetes. Participants will take doses of AZD4248 and may also track their kidney function at home.
Recruiting
Renal Impairment Study for Oral EC5026
PHASE1 Sacramento, California NCT07694544
This trial is looking for adults aged 55 and older with chronic kidney disease. Participants will take a single dose of the medication EC5026 and will be monitored for safety and how the medication is processed in the body.
Recruiting
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
PHASE2 Decatur, Alabama +4 sites NCT05485961
This trial is looking for adults with end stage kidney disease who are undergoing dialysis and have systemic inflammation. Participants will receive a study medication or a placebo to see how it affects heart health.
Recruiting
Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
PHASE2 Huntington Beach, California +4 sites NCT07271186
This trial is looking for adults with diabetic kidney disease to test some new medications. Participants will help researchers understand how safe and effective these medications are.
Recruiting
Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants
NA San Dimas, California +4 sites NCT06613568
This trial is looking for adults with end stage kidney disease who have stable kidney function and can learn how to use a new hemodialysis system. Participants will either use the system under professional care or at home with a trained care partner.
Recruiting
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
PHASE3 Beverly Hills, California +4 sites NCT06742723
This trial is looking for adults with chronic kidney disease and high blood pressure. If you join, you will take medications to see how they affect your kidney health and heart-related risks.
Recruiting
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
PHASE2 Alabaster, Alabama +4 sites NCT05312879
This trial is looking for adults and children with a specific type of kidney disease caused by genetics. Participants will receive the drug VX-147 to assess its effectiveness and safety.
Recruiting
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
PHASE2 Glendale, California +4 sites NCT07355296
This trial is looking for adults and older teenagers with specific kidney diseases who have been stable on certain medications for at least a couple of months. They need to be in good enough health with manageable blood pressure. However, if you have had an organ transplant or recently used strong immunosuppressive treatments, you can't participate.
Recruiting
ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
PHASE2 Huntington Park, California +4 sites NCT06902558
This trial is looking for adults with a specific type of kidney disease. Participants will receive either the study drug or a placebo every 4 weeks for 92 weeks and will attend regular check-ups.
Recruiting
Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease
PHASE2 Beverly Hills, California +4 sites NCT06824987
This trial is looking for adults of African descent with a specific type of kidney disease. Participants will take the drug AZD2373 and attend check-ups to see how well the treatment works and if it is safe.
Recruiting
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
PHASE2 Sacramento, California +1 sites NCT04984226
This trial is looking for people with chronic kidney disease and metabolic acidosis to study how sodium bicarbonate affects muscle health and physical endurance. Participants will be monitored while receiving treatment to understand the impact on their condition.
Recruiting
Ferric Citrate and Chronic Kidney Disease in Children
PHASE2 Los Angeles, California +4 sites NCT04741646
This trial is looking for children aged 6 to 18 with chronic kidney disease stages 3-4. Participants will take either ferric citrate or a placebo for 12 months to see how it affects their health.
Recruiting
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
PHASE1 Loma Linda, California +4 sites NCT07228364
This trial is looking for adults with a specific type of kidney disease who can receive a new treatment called AZD1613. Participants will either receive the treatment through an injection under the skin or directly into the bloodstream and will be monitored for safety and how the body processes the drug.
Recruiting
A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy
PHASE3 Fremont, California +4 sites NCT06963827
This trial is looking for adults with a kidney condition called IgA nephropathy. Participants will receive either mezagitamab or a placebo for 22 weeks and then be monitored for about 1.5 years.
Recruiting
Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)
N/A Victorville, California +3 sites NCT07059962
This trial is looking for adults with kidney disease who are on peritoneal dialysis. Participants will help explore a new way to predict health issues related to fluid overload.
Recruiting
See all 47 Kidney Disease trials in California

Where the Kidney Disease studies are in California

Research sites running the most studies
  • Research Site, Concord5 trials
  • Academic Medical Research Institute, Los Angeles4 trials
  • Cedars-Sinai Medical Center, Los Angeles4 trials
  • North America Research Institute, San Dimas4 trials
  • Research Site, Fremont4 trials
  • Research Site, Tarzana4 trials
By city

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Kidney Disease clinical trials in California: common questions

How many Kidney Disease clinical trials are recruiting in California?
TrialFinder currently lists 47 recruiting Kidney Disease clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Kidney Disease clinical trials located in California?
Study sites for the Kidney Disease trials listed on this page include Los Angeles, Beverly Hills, Palo Alto, San Dimas, Glendale, Sacramento. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Kidney Disease clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Kidney Disease trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Kidney Disease clinical trial in California?
Each study sets its own criteria based on age, Kidney Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
What stage of kidney disease do trials look for?
Trials state an eGFR range and a urine protein threshold rather than a stage name; most cover stages 2 to 4. People on dialysis or with a transplant have separate trials written for them.
Do I need a kidney biopsy to join?
Trials for IgA nephropathy, FSGS and lupus nephritis require a past biopsy confirming the diagnosis. Trials for diabetic or general chronic kidney disease do not.
Will I keep my current kidney and blood pressure medicines?
Yes. Kidney trials add the study treatment to a stable regimen, usually including an ACE inhibitor or ARB, and your own nephrologist continues to manage them.
Kidney Disease Trials in Other States
Alabama Alaska Arizona Arkansas Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Kidney Disease Trials

Kidney disease trials evaluate SGLT2 inhibitors, dialysis protocols, renal transplant regimens, and supportive-care strategies for chronic and acute kidney disease.

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