Sodium Bicarbonate Treatment for Chronic Kidney Disease
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Recruiting
Phase 2
Interventional Study
Chronic Kidney Diseases
Metabolic Acidosis
Fatigue
Physical Endurance
Insulin Resistance
Mitochondrial Energetics
Diabetes
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 21 – 85
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 80 (estimated)
- Sponsor
- University of California, Davis · Other
Who this trial is looking for
This trial is looking for people with chronic kidney disease and metabolic acidosis to study how sodium bicarbonate affects muscle health and physical endurance. Participants will be monitored while receiving treatment to understand the impact on their condition.
Are You a Good Fit for This Trial?
You may be able to join if
- I have moderate to severe chronic kidney disease.
- I have metabolic acidosis with low bicarbonate levels.
- I am between 21 and 85 years old.
You may not be able to join if
- I have type 1 diabetes.
- I have poorly controlled diabetes.
- I have uncontrolled high blood pressure.
- I have a history of kidney treatments like dialysis.
- I have severe heart disease or aortic dissection.
- I cannot walk without assistance.
- I have dementia or psychosis.
- I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabol…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Moderate-severe CKD determined by eGFR \<50ml/min per 1.73m2 by CKD EPI equation on at least 2 consecutive occasions.
* Metabolic acidosis defined as bicarbonate level\<24 on two consecutive occasions. Bicarbonate level of 24 or less allowed if eGFR\<=45ml/min per 1.73m2
* Age…
Contacts