Anxiety Trials / Trials in North Carolina
16 Recruiting Trials

Clinical Trials
for Anxiety in North Carolina

16 clinical trials for Anxiety are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.

16
Recruiting trials
14
Study sites
6
Cities
3
Industry-sponsored
5
Phase 2

Anxiety clinical trials in North Carolina: what to expect

Anxiety trials study generalized anxiety disorder, social anxiety, panic disorder and often post-traumatic stress alongside them. The treatments under study range from new medicines and repurposed ones to cognitive behavioral therapy delivered in person, by video or through an app, virtual-reality exposure, and brain stimulation. Many are run by universities and some can be completed largely online, with a small number of in-person visits.

In North Carolina, recruiting anxiety studies are concentrated in Chapel Hill, Durham, Charlotte and Cary, with sites in 2 other cities. 3 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who anxiety trials usually look for

Trials name the diagnosis they study and set a minimum symptom score on a standard questionnaire, confirmed by a clinician interview at screening. Adults 18 to 65 are the usual range, with separate studies for teenagers and older adults. Typical exclusions are bipolar disorder, psychosis, a current substance use disorder and, for some medicine trials, daily benzodiazepine use. Stable antidepressant treatment is often allowed.

What taking part involves

After a screening interview, medicine trials run eight to twelve weeks with visits every one to two weeks, questionnaires and sometimes blood work; placebo arms are common. Therapy trials involve weekly sessions for eight to sixteen weeks, often with a comparison group that gets the program later. Some studies add brain imaging or a wearable to track sleep and heart rate. Everything study-related is free, and most trials pay for your time.

Questions worth asking the study team

Which visits must be in person; whether you can continue your current medicine or therapy; the chance of placebo or of a waiting-list group; and what support is available if symptoms get worse during the study.

Showing 16 of 16 recruiting Anxiety trials in North Carolina

A New Intervention to Improve Function in Veterans With Anxiety and Depression
PHASE2 Durham, North Carolina NCT06188923
This trial is looking for veterans who experience symptoms of anxiety and depression. Participants will take a medication called pregnenolone to see if it helps improve their symptoms and overall functioning.
Recruiting
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
PHASE2 Birmingham, Alabama +4 sites NCT07489651
This trial is looking for people with Generalized Anxiety Disorder (GAD) to see if a single injection of RE104 can help reduce their anxiety symptoms. Participants will be compared to those receiving a placebo, which is an inactive treatment.
Recruiting
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
PHASE2 Huntsville, Alabama +4 sites NCT06846320
This trial is looking for adults with generalized anxiety disorder (GAD) who have not had enough relief from their current antidepressant medications. Participants will take capsules of either ABBV-932 or a placebo for 6 weeks, along with their existing treatment, and attend regular check-up visits to monitor their progress.
Recruiting
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
PHASE2 Sherman Oaks, California +4 sites NCT06809179
This trial is looking for adults aged 18 to 65 who have social anxiety disorder. Participants will use a nasal spray to help relieve anxiety symptoms caused by public speaking challenges.
Recruiting
Animal Assisted Therapy in Pediatric Dentistry
NA Chapel Hill, North Carolina NCT05464888
This trial is looking for children aged 4 to 8 who are anxious about dental visits. Participants will receive a dental exam with or without the presence of a therapy dog, and their stress levels will be measured.
Recruiting
Adverse Adolescent Pathways to Substance Use
NA Chapel Hill, North Carolina NCT06977178
This trial is looking for young people aged 12 to 14 who have symptoms of anxiety. Participants will answer questions, complete tasks while their brain activity is measured, and have their heart rate and stress responses recorded.
Recruiting
Mitigating PTSD-CUD After Sexual Assault
PHASE1 Chapel Hill, North Carolina +4 sites NCT05989841
This trial is looking for women who have recently experienced sexual assault and may be struggling with PTSD and cannabis use. Participants will use a digital therapy to help address these issues.
Recruiting
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
NA Durham, North Carolina +1 sites NCT05120635
This trial is looking for adults who have received neurostimulation treatment and want to help us understand how fear and anxiety work in the brain. Participants will complete tasks on a computer and in virtual reality while we measure their brain activity, heart rate, and skin sweat.
Recruiting
ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period
NA Charlotte, North Carolina NCT07203534
This trial is looking for patients who need a bone marrow biopsy or aspiration. Participants will test if using a virtual reality headset can help lessen pain and anxiety during the procedure.
Recruiting
Effectiveness of Virtual Reality (VR) in the Management of Anxiety for Patients Undergoing Radiotherapy
NA High Point, North Carolina NCT07324577
This trial is looking for patients with prostate, breast, lung, or head and neck cancer who are scheduled for radiation therapy. Participants will use virtual reality to help manage anxiety during their treatment sessions.
Recruiting
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
N/A Orange, California +4 sites NCT07048574
This trial is looking for children aged 18 months to 11 years who have cystic fibrosis. Participation involves being followed by a care team and discussing mental health issues like depression and anxiety.
Recruiting
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families
NA Durham, North Carolina NCT06627764
This trial is looking for Hispanic/Latino families. Participants will take part in a six-session program to improve health and resilience while managing stress related to immigration.
Recruiting
Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)
NA Chapel Hill, North Carolina NCT06587230
This trial is looking for teachers, counselors, and students in North Carolina to test a new way of providing mental health care to children. Participants will help evaluate how well this approach works in schools.
Recruiting
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
NA Durham, North Carolina NCT06538246
This trial is looking for adults who have recently been in an ICU for serious breathing or heart problems. Participants will use a mobile app to help manage symptoms like depression and anxiety over six months.
Recruiting
Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
NA Chapel Hill, North Carolina +1 sites NCT06060860
This trial is looking for autistic adults aged 18 and older who experience depression or anxiety. Participants will compare two types of therapy sessions delivered online: cognitive-behavioral therapy and mindfulness-based therapy.
Recruiting
Neurostimulation Versus Therapy for Problems With Emotions
NA Durham, North Carolina NCT05712057
This trial is looking for adults who struggle with managing emotions and have mood or anxiety disorders. Participants will receive training on emotion regulation skills and a type of brain stimulation in a single session.
Recruiting
See all 16 Anxiety trials in North Carolina

Where the Anxiety studies are in North Carolina

Research sites running the most studies
  • University of North Carolina at Chapel Hill, Chapel Hill3 trials
  • Duke University Medical Center, Durham2 trials
  • Atrium Health Wake Forest Baptist Hayworth Cancer Center, High Point1 trial
  • Duke School of Nursing, Durham1 trial
  • Duke University Health System, Durham1 trial
  • Durham VA Medical Center, Durham, NC, Durham1 trial
By city

Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.

Anxiety clinical trials in North Carolina: common questions

How many Anxiety clinical trials are recruiting in North Carolina?
TrialFinder currently lists 16 recruiting Anxiety clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Anxiety clinical trials located in North Carolina?
Study sites for the Anxiety trials listed on this page include Durham, Chapel Hill, Charlotte, High Point. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Anxiety clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Anxiety trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Anxiety clinical trial in North Carolina?
Each study sets its own criteria based on age, Anxiety diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I take part in an anxiety trial if I am already in therapy?
Often yes for medicine trials, if the therapy is ongoing and stable. Trials testing a therapy usually ask that you are not starting another one at the same time. The listing states its rule.
Are there anxiety studies I can do online?
Yes. Many app-based and video-therapy studies are mostly remote, though most still need one or two in-person visits, so distance to the site still matters.
Is there a placebo in anxiety trials?
Medicine trials usually include a placebo arm and say so in the consent form. Therapy trials compare against usual care or a group that receives the program after a delay.
Anxiety Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Anxiety Trials

Anxiety disorder trials study CBT approaches, novel anxiolytics, MDMA-assisted therapy, and neuromodulation techniques for GAD, social anxiety, and PTSD.

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