No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
300 (estimated)
Sponsor
University of North Carolina, Chapel Hill · Other
Who this trial is looking for
This trial is looking for autistic adults aged 18 and older who experience depression or anxiety. Participants will compare two types of therapy sessions delivered online: cognitive-behavioral therapy and mindfulness-based therapy.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I have been diagnosed with depression and/or anxiety
I live in North Carolina or Virginia
I can participate in therapy sessions online
I speak English
I have a professional diagnosis of autism or meet the autism screening criteria
You may not be able to join if
I cannot provide informed consent due to altered mental status such as psychosis or intoxication
I am at imminent risk of suicide
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition. Depression and anxiety are the most common of these conditions among autistic adults, contributing to long-term detrimental effects on health, day-to-day functioning, and quality of life. This study will conduct the first large-sca…
Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition. Depression and anxiety are the most common of these conditions among autistic adults, contributing to long-term detrimental effects on health, day-to-day functioning, and quality of life. This study will conduct the first large-scale head-to-head comparison of the two most widely studied mental health interventions for autistic adults: cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT). Both interventions are well-established, empirically supported treatments for depression and anxiety in the general population, and both interventions have demonstrated efficacy among autistic adults. However, their comparative effectiveness and heterogeneity of treatment effects have not been established in autistic adults. Both interventions will be delivered by telehealth.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* ≥18 years of age
* Co-occurring depression and/or anxiety as determined by a total score ≥10 on the PHQ-ADS
* Living in North Carolina or Virginia
* Ability to participate in therapy sessions over telehealth
* English-speaking
* Provide proof of a professional diagnosis of aut…
Inclusion Criteria:
* ≥18 years of age
* Co-occurring depression and/or anxiety as determined by a total score ≥10 on the PHQ-ADS
* Living in North Carolina or Virginia
* Ability to participate in therapy sessions over telehealth
* English-speaking
* Provide proof of a professional diagnosis of autism OR meet or exceed clinical cut-off on the Social Responsiveness Scale (SRS-2) autism screening instrument
Exclusion Criteria:
* Altered mental status that precludes the ability to provide informed assent or consent (acute psychosis, intoxication, or mania)
* Imminent risk of suicide
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