Heart Disease Trials / Trials in North Carolina
25 Recruiting Trials

Clinical Trials
for Heart Disease in North Carolina

25 clinical trials for Heart Disease are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.

25
Recruiting trials
19
Study sites
9
Cities
11
Industry-sponsored
2
Phase 2
2
Phase 3

Heart Disease clinical trials in North Carolina: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In North Carolina, recruiting heart disease studies are concentrated in Durham, Chapel Hill, Charlotte and Greensboro, with sites in 5 other cities. 11 of the 25 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 20 of 25 recruiting Heart Disease trials in North Carolina

Cord Clamping Among Neonates With Congenital Heart Disease
NA Birmingham, Alabama +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
NA San Francisco, California +4 sites NCT06854458
This trial is looking for people who experience chest pain or shortness of breath to find out if these symptoms are due to a heart issue. Participants will undergo a special heart imaging test during exercise-like conditions to measure blood flow to the heart.
Recruiting
Autus Valve Continued Access Study (CAS)
NA Los Angeles, California +4 sites NCT07466745
This trial is looking for children aged 18 months to 16 years who need surgery to replace their pulmonary valve. Participants will have regular check-ups over 10 years to see how well the Autus Valve works as they grow.
Recruiting
Ventripoint Single Ventricle Study
NA Durham, North Carolina NCT05262907
This trial is looking for children and young adults with a single-ventricle heart condition. Participants will undergo heart imaging tests like echocardiograms or MRIs to help assess their heart size and function.
Recruiting
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
PHASE2 Chapel Hill, North Carolina NCT07685938
This trial is looking for adult patients receiving radiation therapy for certain chest tumors. Participants will take either a statin or an ACE inhibitor to see if it helps protect their heart from damage caused by radiation.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
A Usability Study of a Multi-channel ECG Monitoring Device
NA New London, North Carolina NCT07388355
This trial is looking for adults over 18 to test the WearLinq eWave patch. Participants will help evaluate how easy it is to use this heart monitoring device.
Recruiting
Healthy Living Anson Study
NA Chapel Hill, North Carolina NCT07126587
This trial is looking for adults living in Anson County who have or are at risk for a chronic disease. Participants will receive education and healthy meals to see if it improves their diet compared to those who only get physical activity education.
Recruiting
Personalized Environment and Genes Study
N/A Chapel Hill, North Carolina +1 sites NCT00341237
This trial is looking for adults with asthma, diabetes, or heart disease to study how our environment and genes affect health. Participants will need to visit a clinical research unit for enrollment and follow-up appointments.
Recruiting
Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation
N/A Durham, North Carolina NCT07214350
This trial is looking for people who have recently started cardiac rehabilitation. Participants will take part in fitness testing and interviews over 10 months to help understand how men and women stay active during and after their rehab.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
PKP2-ACM Natural History Study
N/A Durham, North Carolina +2 sites NCT06644742
This trial is looking for people aged 12 and older who have been diagnosed with Arrhythmogenic Cardiomyopathy caused by specific genetic changes. Participants will contribute to understanding the condition's progression and current management practices.
Recruiting
CTSN Embolic Protection Trial
NA North Little Rock, Arkansas +4 sites NCT06027788
This trial is looking for patients aged 60 and older who are scheduled for certain types of heart valve surgeries. By participating, I would be helping to test a device designed to protect the heart during the procedure.
Recruiting
Medtronic Cardiac Surgery PMCF Registry
N/A Marietta, Georgia +4 sites NCT04073420
This trial is looking for patients who have valve disease and are receiving certain heart treatments. Participants will help gather information about these treatments after they have been used in the market.
Recruiting
Depression, Aging, Stress and Heart Health Study
NA Chapel Hill, North Carolina NCT05570721
This trial is looking for women aged 44 to 55 who are in the late perimenopause phase. Participants will help researchers understand how depression and stress may affect heart health during this time.
Recruiting
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
N/A Orange, California +4 sites NCT06699056
This trial is looking for adults who can wear a heart monitor to help assess how well their heart pumps blood. Participants will wear the monitor while resting, and their heart function results will be compared to another test to check the accuracy of the new technology.
Recruiting
See all 25 Heart Disease trials in North Carolina

Where the Heart Disease studies are in North Carolina

Research sites running the most studies
  • Duke University, Durham6 trials
  • Duke University Medical Center, Durham4 trials
  • University of North Carolina at Chapel Hill, Chapel Hill4 trials
  • Duke University Hospital, Durham2 trials
  • ABio Clinical Research Partners, New London1 trial
  • Atrium Health - Sanger Heart & Vascular Institute, Charlotte1 trial
By city

Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in North Carolina: common questions

How many Heart Disease clinical trials are recruiting in North Carolina?
TrialFinder currently lists 25 recruiting Heart Disease clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in North Carolina?
Study sites for the Heart Disease trials listed on this page include Durham, Chapel Hill, New London. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in North Carolina?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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