Heart Disease Trials / Trials in Michigan
19 Recruiting Trials

Clinical Trials
for Heart Disease in Michigan

19 clinical trials for Heart Disease are currently recruiting participants at study sites in Michigan. Study-related care is provided at no cost.

19
Recruiting trials
17
Study sites
7
Cities
11
Industry-sponsored
1
Phase 2
2
Phase 3

Heart Disease clinical trials in Michigan: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Michigan, recruiting heart disease studies are concentrated in Ann Arbor, Detroit, Grand Rapids and Royal Oak, with sites in 3 other cities. 11 of the 19 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 19 of 19 recruiting Heart Disease trials in Michigan

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Phoenix, Arizona +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Phoenix, Arizona +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
N/A Grand Rapids, Michigan +4 sites NCT06932081
This trial is looking for adults with congenital heart defects who have started treatment with SGLT2 inhibitors. Participation involves allowing researchers to collect data on how these drugs affect heart health and safety.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
Autus Valve Continued Access Study (CAS)
NA Ann Arbor, Michigan +4 sites NCT07466745
This trial is looking for children aged 18 months to 16 years who need surgery to replace their pulmonary valve. Participants will have regular check-ups over 10 years to see how well the Autus Valve works as they grow.
Recruiting
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
NA Stanford, California +4 sites NCT07525843
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
Recruiting
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
NA Tucson, Arizona +4 sites NCT07214376
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
PHASE2 Los Angeles, California +4 sites NCT06927739
This trial is looking for participants with a history of heart attack and high levels of coronary inflammation. Taking part involves receiving either orticumab or a placebo for 6 months while continuing regular doctor visits.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
CTSN Embolic Protection Trial
NA North Little Rock, Arkansas +4 sites NCT06027788
This trial is looking for patients aged 60 and older who are scheduled for certain types of heart valve surgeries. By participating, I would be helping to test a device designed to protect the heart during the procedure.
Recruiting
Medtronic Cardiac Surgery PMCF Registry
N/A Ann Arbor, Michigan +4 sites NCT04073420
This trial is looking for patients who have valve disease and are receiving certain heart treatments. Participants will help gather information about these treatments after they have been used in the market.
Recruiting
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
N/A Detroit, Michigan +4 sites NCT06699056
This trial is looking for adults who can wear a heart monitor to help assess how well their heart pumps blood. Participants will wear the monitor while resting, and their heart function results will be compared to another test to check the accuracy of the new technology.
Recruiting
ATrial Tachycardia PAcing Therapy in Congenital Heart
N/A Los Angeles, California +4 sites NCT03209583
This trial is looking for people with congenital heart disease who have an atrial arrhythmia and an implanted atrial anti-tachycardia device where the therapy is active. Participants will help researchers understand how effective this treatment is for their condition.
Recruiting
The TRICURE EFS Study
NA Ann Arbor, Michigan +4 sites NCT06506942
This trial is looking for adults with severe tricuspid regurgitation who are considered at higher risk for surgery. Participants will be evaluated by a heart team and may receive a new heart valve device.
Recruiting
See all 19 Heart Disease trials in Michigan

Where the Heart Disease studies are in Michigan

Research sites running the most studies
  • University of Michigan, Ann Arbor7 trials
  • Henry Ford Hospital, Detroit3 trials
  • University of Michigan Health System, Ann Arbor, Ann Arbor2 trials
  • Abcentra Investigational Site, Midland1 trial
  • Ascension St. Marys Research Institute, Saginaw1 trial
  • Children's Hospital of Michigan, Detroit1 trial
By city

Counts are recruiting studies listing at least one site in Michigan, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Michigan: common questions

How many Heart Disease clinical trials are recruiting in Michigan?
TrialFinder currently lists 19 recruiting Heart Disease clinical trials with study sites in Michigan. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Michigan?
Study sites for the Heart Disease trials listed on this page include Grand Rapids, Ann Arbor, Detroit. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Michigan?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Michigan also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Michigan?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Heart Disease trials near you in Michigan.

Get Matched — Free
No insurance required
About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

All Heart Disease trials →
Other Conditions in Michigan
Diabetes Cancer Breast Cancer Depression Anxiety Alzheimer's Asthma Multiple Sclerosis Obesity Parkinson's Lupus Hypertension COPD Stroke Arthritis Kidney Disease COVID-19
All trials in Michigan →