Lupus Trials / Trials in Michigan
15 Recruiting Trials

Clinical Trials
for Lupus in Michigan

15 clinical trials for Lupus are currently recruiting participants at study sites in Michigan. Study-related care is provided at no cost.

15
Recruiting trials
18
Study sites
9
Cities
11
Industry-sponsored
4
Phase 2
7
Phase 3

Lupus clinical trials in Michigan: what to expect

Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.

In Michigan, recruiting lupus studies are concentrated in Ann Arbor, Detroit, Grand Blanc and Sterling Heights, with sites in 5 other cities. 11 of the 15 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who lupus trials usually look for

Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.

What taking part involves

Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.

Showing 15 of 15 recruiting Lupus trials in Michigan

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
PHASE3 Avondale, Arizona +4 sites NCT06617325
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
Recruiting
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
PHASE3 Anniston, Alabama +4 sites NCT06133972
This trial is looking for people with systemic lupus erythematosus who have completed a previous study using ianalumab. Participants will be monitored for long-term safety and tolerance of the treatment.
Recruiting
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease
PHASE3 Los Angeles, California +4 sites NCT07332481
This trial is looking for people with skin problems related to lupus. If you join, you'll take a treatment called enpatoran for 24 weeks and have visits every 4 weeks.
Recruiting
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
PHASE3 Upland, California +4 sites NCT07355218
This trial is looking for people with active skin symptoms of lupus, with or without other types of lupus disease. If you join, you will take a medication called enpatoran for 24 weeks and visit the study site every 4 weeks.
Recruiting
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
PHASE3 Beverly Hills, California +4 sites NCT07438496
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
Recruiting
A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment
PHASE3 Doral, Florida +4 sites NCT07201129
This trial is looking for adults with active lupus nephritis who are receiving standard treatment. Participants will take either cenerimod or a placebo for about 1.5 years and attend regular check-ups at the clinic.
Recruiting
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
PHASE2 Beverly Hills, California +4 sites NCT07409181
This trial is looking for adults with systemic lupus erythematosus (SLE) to see if a medicine called BI 3000202 can help them. Participants will take the medicine or a placebo for one year while continuing their regular SLE treatment.
Recruiting
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
PHASE2 Beverly Hills, California +4 sites NCT07260877
This trial is looking for adults with cutaneous lupus who may also have systemic lupus. Participants will take the study drug VENT-03 or a placebo for a total of 12 weeks and visit the clinic monthly for checkups.
Recruiting
VIBRANT: VIB4920 for Active Lupus Nephritis
PHASE2 La Jolla, California +4 sites NCT05201469
This trial is looking for adults with active lupus nephritis. Participants will take VIB4920 along with other medications to see if it helps improve kidney function.
Recruiting
Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus
NA Grand Rapids, Michigan +4 sites NCT06232304
This trial is looking for young people with childhood-onset lupus to join a program that helps them learn to cope with fatigue, pain, and depression. Participants will receive this support alongside their regular medical care.
Recruiting
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
N/A La Jolla, California +4 sites NCT07175285
This trial is looking for people with active systemic lupus erythematosus who have not responded well to previous treatments. Participants will need to meet specific health criteria and may undergo assessments to evaluate their condition.
Recruiting
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
PHASE3 Phoenix, Arizona +4 sites NCT07691970
This trial is looking for people who have finished another study with anifrolumab and are still benefiting from it. Participants will continue to receive anifrolumab and will be monitored for safety.
Recruiting
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
PHASE1 Little Rock, Arkansas +4 sites NCT06557265
This trial is looking for adults with certain autoimmune diseases like lupus nephritis. Participants will receive NKX019 treatment and will need to attend scheduled visits during the study.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting
Brief Pain Exposure Therapy (BPET) For Nociplastic Pain
NA Ann Arbor, Michigan NCT06208514
This trial is looking for adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. Participants will join a brief Zoom-based therapy to learn strategies for managing their pain and related challenges.
Recruiting
See all 15 Lupus trials in Michigan

Where the Lupus studies are in Michigan

Research sites running the most studies
  • University of Michigan, Ann Arbor2 trials
  • AA MRC, Grand Blanc1 trial
  • AA MRC LLC - Grand Blanc, Grand Blanc1 trial
  • Ahmed Arif Medical Research Center, Grand Blanc1 trial
  • Helen Devos Children's Hospital, Grand Rapids1 trial
  • Henry Ford Health, Detroit1 trial
By city

Counts are recruiting studies listing at least one site in Michigan, from ClinicalTrials.gov, refreshed every two days.

Lupus clinical trials in Michigan: common questions

How many Lupus clinical trials are recruiting in Michigan?
TrialFinder currently lists 15 recruiting Lupus clinical trials with study sites in Michigan. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Michigan?
Study sites for the Lupus trials listed on this page include Grand Rapids, Ann Arbor. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in Michigan?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Michigan also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Michigan?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
Lupus Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Lupus Trials

Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.

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Other Conditions in Michigan
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