21 Recruiting Trials
Clinical Trials
for Lupus in Illinois
21 clinical trials for Lupus are currently recruiting participants at study sites in Illinois. Study-related care is provided at no cost.
21
Recruiting trials
22
Study sites
5
Cities
16
Industry-sponsored
7
Phase 2
6
Phase 3
Lupus clinical trials in Illinois: what to expect
Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.
In Illinois, recruiting lupus studies are concentrated in Chicago, Willowbrook, Orland Park and Hinsdale, with sites in 1 other city. 16 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who lupus trials usually look for
Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.
What taking part involves
Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.
Showing 20 of 21 recruiting Lupus trials in Illinois
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
Recruiting
This trial is looking for people with systemic lupus erythematosus who have completed a previous study using ianalumab. Participants will be monitored for long-term safety and tolerance of the treatment.
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Recruiting
This trial is looking for children with moderate to severe systemic lupus erythematosus (SLE) to test a treatment called Anifrolumab. Participants will be monitored to understand how well the treatment works and its safety.
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with systemic lupus erythematosus (SLE) who have not used immunosuppressive drugs before. Participants will receive anifrolumab as an additional treatment to their regular medications for SLE.
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with active systemic lupus erythematosus or lupus nephritis. Participants will receive the treatment CABA-201 and will be monitored for safety and effectiveness.
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Recruiting
This trial is looking for people with active lupus nephritis. Participants will take a medication called LNP023 along with their usual treatment to see how well it works and how safe it is.
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
Recruiting
This trial is looking for people aged 16-70 who have systemic lupus erythematosus that hasn't responded to treatment. Participants will receive a special infusion after a preparatory treatment to help their condition.
VIBRANT: VIB4920 for Active Lupus Nephritis
Recruiting
This trial is looking for adults with active lupus nephritis. Participants will take VIB4920 along with other medications to see if it helps improve kidney function.
The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
Recruiting
This trial is looking for young people aged 8 to 20 with lupus nephritis. Participants will take a medication called Mycophenolate Mofetil and visit the study site regularly for assessments.
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Recruiting
This trial is looking for adults aged 18 to 70 who have severe systemic lupus erythematosus that hasn’t improved with other treatments. Participants will receive a special therapy called AZD0120 and will be monitored for its safety and effectiveness.
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Recruiting
This trial is looking for adults with systemic lupus erythematosus or rheumatoid arthritis. Participants will receive treatment and attend regular check-ups to assess the effects and safety of the drug.
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
Recruiting
This trial is looking for people with active systemic lupus erythematosus who have not responded well to previous treatments. Participants will need to meet specific health criteria and may undergo assessments to evaluate their condition.
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
Recruiting
This trial is looking for pregnant women with systemic lupus erythematosus or antiphospholipid syndrome to understand how certain proteins may affect pregnancy outcomes. Participants will be monitored throughout their pregnancy to see if these proteins can predict complications.
Lupus Landmark Study: A Prospective Registry and Biorepository
Recruiting
This trial is looking for adults aged 18 or older who have been diagnosed with systemic lupus erythematosus (SLE), including lupus nephritis. Participants will help gather important data and samples for future research.
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
Recruiting
This trial is looking for people who have finished another study with anifrolumab and are still benefiting from it. Participants will continue to receive anifrolumab and will be monitored for safety.
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Recruiting
This trial is looking for adults with certain autoimmune diseases like lupus nephritis. Participants will receive NKX019 treatment and will need to attend scheduled visits during the study.
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Recruiting
This trial is looking for adults between 18 and 75 years old who have active autoimmune diseases like lupus, myopathy, or scleroderma that haven't responded well to standard treatments. They also want to make sure participants are generally healthy and don’t have serious infections or certain other health issues, like recent heart problems or cancer. If someone has had certain types of previous treatments or has unstable health, they wouldn’t be able to join.
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Recruiting
This trial is looking for adults with certain autoimmune diseases, like systemic lupus erythematosus and systemic sclerosis. Participants will receive the treatment CTX112 and will need to attend regular visits and follow study guidelines.
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)
Recruiting
This trial is looking for adults with systemic lupus erythematosus, Sjogren's disease, or rheumatoid arthritis. Participants will receive two doses of an investigational drug called ABBV-319 and will be monitored for about a year.
Where the Lupus studies are in Illinois
Research sites running the most studies
- Research Site, Chicago3 trials
- University of Chicago, Chicago3 trials
- Northwestern University, Chicago2 trials
- Advanced Quality Medical Research /ID# 278462, Orland Park1 trial
- Advanced Quality Medical Research /ID# 279147, Orland Park1 trial
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago1 trial
By city
Counts are recruiting studies listing at least one site in Illinois, from ClinicalTrials.gov, refreshed every two days.
Lupus clinical trials in Illinois: common questions
How many Lupus clinical trials are recruiting in Illinois?
TrialFinder currently lists 21 recruiting Lupus clinical trials with study sites in Illinois. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Illinois?
Study sites for the Lupus trials listed on this page include Chicago, Orland Park. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in Illinois?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Illinois also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Illinois?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Lupus Trials
Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.
All Lupus trials →