54 Recruiting Trials

Clinical Trials
for Stroke in Illinois

54 clinical trials for Stroke are currently recruiting participants at study sites in Illinois. Study-related care is provided at no cost.

54
Recruiting trials
48
Study sites
16
Cities
12
Industry-sponsored
5
Phase 2
5
Phase 3

Stroke clinical trials in Illinois: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In Illinois, recruiting stroke studies are concentrated in Chicago, Evanston, Park Ridge and Rockford, with sites in 12 other cities. 12 of the 54 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 54 recruiting Stroke trials in Illinois

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
PHASE2 Fairhope, Alabama +4 sites NCT05065216
This trial is looking for adults who have had a moderate stroke and present within 24 hours of the onset. Participants will receive a study medication to see if it helps improve their condition.
Recruiting
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
NA Chicago, Illinois NCT05167786
This trial is looking for individuals with hemiplegia from a stroke to see if a non-invasive spinal cord stimulation treatment can improve walking and balance. Participants will need to be at least 18 years old and have had their stroke at least 6 months ago.
Recruiting
Tele-CE in Severe Stroke
NA Chicago, Illinois NCT07652970
This trial is looking for people who have had a severe stroke more than six months ago. Participants will do home exercises with remote support to improve their lower limb function and brain activity.
Recruiting
Effect of Neural Constraints on Movement in Stroke
EARLY_PHASE1 Chicago, Illinois NCT06666673
This trial is looking for participants who have had a stroke at least six months ago and have some difficulty moving their arms. Taking part involves receiving a medication called Tizanidine and undergoing assessments of movement and brain activity.
Recruiting
Self-Directed Upper Extremity Gaming in Inpatients With Stroke
NA Chicago, Illinois NCT07806097
This trial is looking for patients who have had a stroke and are in rehabilitation. Participants will play games that help improve arm and hand movements using a camera and TV, no controllers needed.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA Tucson, Arizona +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
Alternative Therapies for Improving Physical Function in Individuals With Stroke
NA Chicago, Illinois +1 sites NCT03869138
This trial is looking for adults aged 18 to 90 who have had a stroke or other neurological impairment. Participants will try a new dance and gaming therapy to see if it helps improve physical function compared to standard therapies.
Recruiting
MINT Conditioning to Improve Gait
NA Chicago, Illinois +1 sites NCT07041775
This trial is looking for adults aged 18 to 85 who have experienced a stroke and have difficulty walking. Participants will engage in training designed to improve their walking function.
Recruiting
Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
NA Chicago, Illinois NCT04312269
This trial is looking for stroke survivors aged 21 or older with difficulty moving their arms. Participants will train using a special computer interface combined with sleep techniques to help improve arm function.
Recruiting
Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal
NA Chicago, Illinois NCT04477330
This trial is looking for people who have had a stroke and want to improve their walking ability. Participants will take part in a rehabilitation program that includes brain stimulation to help enhance their walking outcomes.
Recruiting
Characterization and Clinical Trial of a Variable Friction Shoe
NA Chicago, Illinois NCT06234124
This trial is looking for people who have experienced foot drop after a stroke. Participants will use a special shoe to help improve their walking abilities at home while following an exercise program for six months.
Recruiting
Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke
NA Chicago, Illinois NCT03401762
This trial is looking for people who have had a stroke to test a wearable device that may help improve arm movement. Participants will use the device at home to see if it can help reduce problems with muscle coordination.
Recruiting
Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments
NA Urbana, Illinois NCT05479006
This trial is looking for people who have had a stroke and have trouble moving one arm. Participants will receive targeted brain stimulation to see if it helps improve movement in their affected arm.
Recruiting
Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke
NA Chicago, Illinois NCT06598150
This trial is looking for adults who have had a stroke and have weakness on one side of their body. Participants will undergo an MRI while performing a shoulder movement task to help understand brain activity during recovery.
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Birmingham, Alabama +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
N/A Birmingham, Alabama +4 sites NCT05338697
This trial is looking for adults who have had a stroke and are experiencing motor difficulties in one arm. Participants will undergo specific tests and procedures to help researchers understand recovery outcomes.
Recruiting
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
N/A Chicago, Illinois +4 sites NCT00682695
This trial is looking for adults who have had a hemorrhagic stroke. Participants will provide consent for interviews, blood pressure checks, and blood sampling.
Recruiting
Inpatient Stroke Recovery Using Sensors
N/A Chicago, Illinois NCT04219670
Recruiting

Where the Stroke studies are in Illinois

  • Shirley Ryan AbilityLab, Chicago10 trials
  • Northwestern University, Chicago6 trials
  • University of Chicago, Chicago6 trials
  • University of Chicago Medical Center, Chicago6 trials
  • University of Illinois at Chicago, Chicago5 trials
  • Rush University Medical Center, Chicago3 trials

Counts are recruiting studies listing at least one site in Illinois, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in Illinois: common questions

How many Stroke clinical trials are recruiting in Illinois?
TrialFinder currently lists 54 recruiting Stroke clinical trials with study sites in Illinois. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in Illinois?
Study sites for the Stroke trials listed on this page include Chicago, Urbana. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in Illinois?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in Illinois also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in Illinois?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Stroke trials near you in Illinois.

Get Matched — Free
No insurance required

Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

All Stroke trials →