No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
32 (estimated)
Sponsor
Northwestern University · Other
Who this trial is looking for
This trial is looking for adults who have had a stroke and have weakness on one side of their body. Participants will undergo an MRI while performing a shoulder movement task to help understand brain activity during recovery.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I can do a shoulder movement task
I am safe to have an MRI
I can follow visual instructions
I do not have brainstem or cerebellar lesions
I can focus on a task
I speak English or Spanish
I had a stroke with a specific type of brain lesion over a year ago
You may not be able to join if
I have severe claustrophobia
I am pregnant
I am a prisoner
I have had a brain tumor or brain radiation
I have a history of multiple sclerosis or traumatic brain injury
I have dementia or Parkinson's disease
I am part of another intervention study
I take medications that suppress my brain activity
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Adults aged at least 18y
* Able to perform shoulder abduction task (confirmed during screening and initial examination)
* Safe to undergo MRI
* Able to follow visual instructions using MRI-compatible vision correction goggles
* No brainstem or cerebellar lesions
* No severe co…
Inclusion Criteria:
* Adults aged at least 18y
* Able to perform shoulder abduction task (confirmed during screening and initial examination)
* Safe to undergo MRI
* Able to follow visual instructions using MRI-compatible vision correction goggles
* No brainstem or cerebellar lesions
* No severe concurrent medical problems
* Cognitive/attentional capacity to focus on a task
* Able to communicate in English or Spanish
Additional inclusion criteria for stroke participants:
* Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
* Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).
Exclusion Criteria:
* MRI contraindications
* Severe claustrophobia
* Pregnant women
* Prisoners
* Vulnerable populations
* Diagnosis/history of:
* multiple sclerosis
* brain tumor
* brain radiation
* traumatic brain injury
* dementia
* Parkinson's disease
* Concurrent enrollment in an intervention study
* Concurrent use of medications known to suppress central nervous system activity
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