No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
University of Illinois at Chicago · Other
Who this trial is looking for
This trial is looking for people who have had a stroke and want to improve their walking ability. Participants will take part in a rehabilitation program that includes brain stimulation to help enhance their walking outcomes.
Are You a Good Fit for This Trial?
Rules you outSevere osteoporosisCognitive impairmentHeart diseaseStroke affecting brainstem or cerebellum
You may be able to join if
I am at least 18 years old.
I had my first stroke more than 3 months ago.
I have some difficulty walking.
I can walk for 5 minutes, even with a walking aid.
My walking speed is less than 1.2 m/s.
My lower limb function score is between 15 and 30.
I can move my ankle up by at least 5 degrees.
You may not be able to join if
I have severe osteoporosis.
I have a contracture that limits my leg movement.
My muscle tone score is more than 2.
I take uncontrolled anti-spasticity medications.
My sensory assessment score is less than 6.
I have heart or lung diseases that are not controlled.
I have had unhealed sores or infections.
I have significant cognitive issues that affect my understanding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to impr…
Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age greater than 18 years
* First ever monohemispheric stroke \> 3 months since onset
* Residual hemiparetic gait deficits (e.g. abnormal gait pattern)
* Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable.
* Walking speed lesser than 1.2 m/…
Inclusion Criteria:
* Age greater than 18 years
* First ever monohemispheric stroke \> 3 months since onset
* Residual hemiparetic gait deficits (e.g. abnormal gait pattern)
* Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable.
* Walking speed lesser than 1.2 m/s
* Lower limb Fugl-Meyer Motor score between 15-30
* At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task
Exclusion Criteria:
* General exclusion criteria
* Severe osteoporosis
* Contracture-limiting range of motion of lower limb
* Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion)
* Uncontrolled anti-spasticity medications during the study period
* Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb
* Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
* Unhealed decubiti, persistent infection
* Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
* Lesions involving the brainstem and cerebellum
* Failure to pass the graded exercise stress test
TMS exclusion criteria
* Implanted cardiac pacemaker
* Metal implants in the head or face
* Unexplained, recurring headaches
* History of seizures or epilepsy
* Currently under medication that could increase motor excitability and lower seizure threshold
* Skull abnormalities or fractures
* Concussion within the last 6 months
* Currently pregnant
tDCS exclusion criteria
* Skin hypersensitivity
* History of contact dermatitits
* History of allodynia and/or hyperalgesia
* Any other skin or scalp condition that could be aggravated by tDCS
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