No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 90
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
Carle Foundation Hospital · Other
Who this trial is looking for
This trial is looking for people who have had a stroke and have trouble moving one arm. Participants will receive targeted brain stimulation to see if it helps improve movement in their affected arm.
Are You a Good Fit for This Trial?
You may be able to join if
I have weakness in one arm due to a stroke.
I can give my consent to participate.
You may not be able to join if
I have unusual muscle tone or problems in my other arm.
I have severe weakness or sensory loss in my affected arm.
I have serious cognitive issues affecting my understanding.
I have severe medical problems affecting my health.
I use a pacemaker.
I have metal implants in my head.
I have had bad reactions to brain stimulation treatments.
I am pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have been hampered by a lack of precision rehabilitation. Previous studies suggest and support the role of…
Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have been hampered by a lack of precision rehabilitation. Previous studies suggest and support the role of cortico-reticulospinal tract (CRST) hyperexcitability in post-stroke flexion synergy. CRST hyperexcitability is often caused by damage to the corticospinal tract (CST). We hypothesize that: 1) inhibiting the contralesional dorsal premotor cortex (cPMd) will directly reduce the CRST hyperexcitability and thus, reduce the expression of the flexion synergy; 2) facilitating the ipsilesional primary motor cortex (iM1) will improve the excitability of the damaged CST, therefore reducing the CRST hyperexcitability and the flexion synergy. we propose to use a novel targeted high-definition tDCS (THD-tDCS) to specifically modulate the targeted cortical regions for testing his hypothesis, via the following aims: Aim 1. Evaluate the effect of cathodal THD-tDCS over the cPMd on reducing the CRST hyperexcitability and the expression of flexion synergy. Aim 2. Evaluate the effect of anodal THD-tDCS over the iM1 on improving the excitability of the CST, and determine whether this, thus, also reduces the CRST hyperexcitability and the flexion synergy. Aim 3. Evaluate the confluence effect of bilateral THD-tDCS, i.e., simultaneous cathodal stimulation over the cPMd and anodal over the iM1.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Paresis confined to one side, with substantial motor impairment of the paretic upper limb
* Capacity to provide informed consent
Exclusion Criteria:
* Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb
* Severe wasting or contracture or signifi…
Inclusion Criteria:
* Paresis confined to one side, with substantial motor impairment of the paretic upper limb
* Capacity to provide informed consent
Exclusion Criteria:
* Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb
* Severe wasting or contracture or significant sensory deficits in the paretic upper limb
* Severe cognitive or affective dysfunction that prevents normal communication and understanding of consent or instruction
* Severe concurrent medical problems (e.g. cardiorespiratory impairment)
* Using a pacemaker
* Metal implants in the head
* Known adverse reactions to TMS and tDCS
* Pregnant
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