56 Recruiting Trials

Clinical Trials
for Stroke in Pennsylvania

56 clinical trials for Stroke are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.

56
Recruiting trials
45
Study sites
13
Cities
14
Industry-sponsored
11
Phase 2
6
Phase 3

Stroke clinical trials in Pennsylvania: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In Pennsylvania, recruiting stroke studies are concentrated in Pittsburgh, Philadelphia, Hershey and Elkins Park, with sites in 9 other cities. 14 of the 56 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 56 recruiting Stroke trials in Pennsylvania

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
PHASE2 Fairhope, Alabama +4 sites NCT05065216
This trial is looking for adults who have had a moderate stroke and present within 24 hours of the onset. Participants will receive a study medication to see if it helps improve their condition.
Recruiting
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
PHASE2 Philadelphia, Pennsylvania NCT06968663
This trial is looking for people who had a stroke 2 to 6 weeks ago and are experiencing difficulties with speaking. Participants will receive treatment that combines Transcranial Magnetic Stimulation and language therapy over 10 sessions, with follow-ups after treatment.
Recruiting
Telerehabilitation In The Home After Stroke
NA Downey, California +4 sites NCT06682429
This trial is looking for people who have arm weakness from a stroke that happened 90 to 150 days ago. Participants will receive telerehabilitation to improve their arm function, alongside usual care, for 6 weeks.
Recruiting
Improving Measurement and Treatment of Post-stroke Neglect
NA Pittsburgh, Pennsylvania NCT03317860
This trial is looking for people who have had a stroke and experience neglect. Participants will try a new treatment that combines repetitive practice with brain stimulation to see how well it helps with their symptoms.
Recruiting
Rehabilitation Strategies for Social Participation in Chronic Stroke Survivors
NA Pittsburgh, Pennsylvania NCT06758505
This trial is looking for people who have had a stroke at least six months ago and are having trouble participating in social activities. Participants will receive a home-based rehabilitation program to help improve their social engagement and will be asked to complete some tests before and after the program.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA Tucson, Arizona +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
Pilot/Pivotal Study of DBS+Rehab After Stroke
NA Phoenix, Arizona +4 sites NCT05701280
This trial is looking for people who had a stroke and still have weakness in their arm. Participants will receive treatment to help improve their arm function.
Recruiting
Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis
NA Pittsburgh, Pennsylvania NCT07153536
This trial is looking for adults who have weakness in their arm and hand due to a stroke that happened at least 6 months ago. Participants will undergo physical therapy and receive a spinal cord implant to help improve their motor control.
Recruiting
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
NA Pittsburgh, Pennsylvania NCT06458153
This trial is looking for healthy adults and people who have had a stroke in the cerebellum. Participants will take part in tests related to speech and undergo brain imaging to help understand how different brain areas work together while listening and speaking.
Recruiting
Brain Connections for Arm Movement After Stroke
NA Pittsburgh, Pennsylvania NCT04286516
Recruiting
Robotic Rehabilitation of the Upper Limb in Subacute Stroke
NA Elkins Park, Pennsylvania +4 sites NCT06839482
Recruiting
Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)
NA Philadelphia, Pennsylvania +1 sites NCT06530693
This trial is looking for patients who may have had a stroke and need transportation to a hospital. Participants will be monitored over 90 days to compare a new way of transporting stroke patients to traditional methods.
Recruiting
The Neuralert Stroke Monitor Pilot Trial
NA Philadelphia, Pennsylvania NCT06368193
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Birmingham, Alabama +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
N/A Birmingham, Alabama +4 sites NCT05338697
This trial is looking for adults who have had a stroke and are experiencing motor difficulties in one arm. Participants will undergo specific tests and procedures to help researchers understand recovery outcomes.
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Birmingham, Alabama +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Mobile, Alabama +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
PHASE3 Tucson, Arizona +4 sites NCT05691244
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a new treatment called sovateltide along with standard care and will be monitored for safety and effectiveness.
Recruiting
Strategy for Improving Stroke Treatment Response
PHASE2 Birmingham, Alabama +4 sites NCT05948566
This trial is looking for adults who have had a suspected ischemic stroke. Participants will receive a treatment called TS23 to see how safe and effective it is within a specific time after their stroke.
Recruiting

Where the Stroke studies are in Pennsylvania

  • University of Pittsburgh, Pittsburgh11 trials
  • Hospital of the University of Pennsylvania, Philadelphia6 trials
  • University of Pennsylvania, Philadelphia5 trials
  • The Hospital of the University of Pennsylvania, Philadelphia4 trials
  • UPMC Presbyterian Hospital, Pittsburgh4 trials
  • Temple University Hospital, Philadelphia3 trials

Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in Pennsylvania: common questions

How many Stroke clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 56 recruiting Stroke clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in Pennsylvania?
Study sites for the Stroke trials listed on this page include Philadelphia, Pittsburgh, Elkins Park. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
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Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

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