No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
100 (estimated)
Sponsor
University of Pittsburgh · Other
Who this trial is looking for
This trial is looking for healthy adults and people who have had a stroke in the cerebellum. Participants will take part in tests related to speech and undergo brain imaging to help understand how different brain areas work together while listening and speaking.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 49 years old and right-handed.
I am a native English speaker.
I am 18 years or older and right-handed, with a history of cerebellar stroke.
I am 18 years or older and right-handed.
You may not be able to join if
I have metal in my body that could interfere with MRI scans.
I have had a severe brain injury other than stroke.
I have hearing loss that affects my ability to hear speech.
I have been diagnosed with schizophrenia or other psychotic disorders.
I have been diagnosed with a neurocognitive disorder.
I have a severe attention disorder that is not managed.
My head circumference is greater than 60cm or my weight is over 300 pounds.
I am currently pregnant or might be pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
1. What regions of the brain's sensory systems show changes in their activity related to speech?
2. To what extent do these region…
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
1. What regions of the brain's sensory systems show changes in their activity related to speech?
2. To what extent do these regions help listeners detect and correct speech errors?
3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Trial Locations
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City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
Cohort 1 (neurotypical adults):
* Age 18-49
* Right-handed
* Native English speaker
Cohort 2 (people with cerebellar lesions):
* Age 18 or older
* Right-handed
* Native English speaker
* History of cerebellar stroke
Cohort 3 (controls matched to Cohort 2)
* Age 18 or older
…
Inclusion Criteria:
Cohort 1 (neurotypical adults):
* Age 18-49
* Right-handed
* Native English speaker
Cohort 2 (people with cerebellar lesions):
* Age 18 or older
* Right-handed
* Native English speaker
* History of cerebellar stroke
Cohort 3 (controls matched to Cohort 2)
* Age 18 or older
* Right-handed
* Native English speaker
Exclusion Criteria:
Cohort 1 (neurotypical adults):
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
* Hearing loss, defined by pure tone thresholds \>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Clinically diagnosed with or treated for a speech, language, or hearing disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
Cohort 2 (people with cerebellar lesions):
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury other than stroke
* Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
Cohort 3 (controls matched to Cohort 2):
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
* Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Clinically diagnosed with or treated for a speech, language, or hearing disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
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