15 Recruiting Trials

Clinical Trials
for Multiple Sclerosis in Michigan

15 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Michigan. Study-related care is provided at no cost.

15
Recruiting trials
17
Study sites
8
Cities
10
Industry-sponsored
4
Phase 2
6
Phase 3

Multiple Sclerosis clinical trials in Michigan: what to expect

Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.

In Michigan, recruiting multiple sclerosis studies are concentrated in Ann Arbor, Detroit, Farmington Hills and Farmington, with sites in 4 other cities. 10 of the 15 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who multiple sclerosis trials usually look for

Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.

What taking part involves

Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.

Questions worth asking the study team

What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.

Showing 15 of 15 recruiting Multiple Sclerosis trials in Michigan

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
PHASE3 Birmingham, Alabama +4 sites NCT07225504
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Recruiting
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
PHASE3 Cullman, Alabama +4 sites NCT07325292
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
PHASE2 Birmingham, Alabama +4 sites NCT06782490
This trial is looking for people with multiple sclerosis (MS) who experience muscle stiffness for at least 6 months. Participants will help evaluate the safety and effectiveness of a new treatment.
Recruiting
Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
PHASE2 Ann Arbor, Michigan NCT05269628
This trial is looking for people with multiple sclerosis (MS) who experience chronic pain and have sleep issues. Participants will receive cannabidiol (CBD), tetrahydrocannabinol (THC), or both, while maintaining their current pain medications during the study.
Recruiting
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
PHASE2 Farmington Hills, Michigan +4 sites NCT06735248
This trial is looking for people aged 18 to 55 with multiple sclerosis. Participants will receive either the study drug, mRNA-1195, or a placebo while being monitored for safety and side effects.
Recruiting
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
N/A Birmingham, Alabama +4 sites NCT06433752
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Recruiting
Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis
N/A Detroit, Michigan NCT04458688
This trial is looking for African American and Caucasian adults with relapsing multiple sclerosis. Participants will receive ocrelizumab and their progress will be monitored using imaging tests.
Recruiting
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
PHASE3 Detroit, Michigan +4 sites NCT04047628
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
PHASE3 Scottsdale, Arizona +4 sites NCT06846281
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
Recruiting
Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients
NA Ann Arbor, Michigan NCT07392879
This trial is looking for people with progressive multiple sclerosis who experience depression. Participants will use virtual reality nature experiences at home as a supplement to their current depression treatment.
Recruiting
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
PHASE3 Phoenix, Arizona +4 sites NCT07299019
This trial is looking for people with Secondary Progressive Multiple Sclerosis who have not had a clinical relapse for at least 2 years. Participants will receive either orelabrutinib or a placebo for 1 to 5 years.
Recruiting
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
PHASE3 Birmingham, Alabama +4 sites NCT05877963
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Recruiting
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
PHASE2 Birmingham, Alabama +4 sites NCT07002034
This trial is looking for people who have been diagnosed with Adjustment Disorder due to cancer or certain other health conditions. Participants will receive a single dose of the study drug to see if it helps reduce their depressive or anxiety symptoms.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
PHASE1 Ann Arbor, Michigan +4 sites NCT06680037
This trial is looking for adults with specific autoimmune disorders who want to explore a new treatment called Azer-cel. Participants will undergo tests and may have a procedure to collect fluid from their spine.
Recruiting

Where the Multiple Sclerosis studies are in Michigan

  • University of Michigan, Ann Arbor3 trials
  • Michigan Institute of Neurological, Farmington Hills2 trials
  • TG Therapeutics Investigational Trial Site, Ann Arbor2 trials
  • Henry Ford Health, Novi1 trial
  • Henry Ford Neuroscience Institute, Detroit1 trial
  • Memorial HC Ins for Neuroscience, Owosso1 trial

Counts are recruiting studies listing at least one site in Michigan, from ClinicalTrials.gov, refreshed every two days.

Multiple Sclerosis clinical trials in Michigan: common questions

How many Multiple Sclerosis clinical trials are recruiting in Michigan?
TrialFinder currently lists 15 recruiting Multiple Sclerosis clinical trials with study sites in Michigan. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Michigan?
Study sites for the Multiple Sclerosis trials listed on this page include Ann Arbor, Farmington Hills, Detroit. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Michigan?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Michigan also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Michigan?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
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MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.

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