Anxiety Trials / Trials in Massachusetts
40 Recruiting Trials

Clinical Trials
for Anxiety in Massachusetts

40 clinical trials for Anxiety are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

40
Recruiting trials
32
Study sites
10
Cities
3
Industry-sponsored
9
Phase 2
1
Phase 3

Anxiety clinical trials in Massachusetts: what to expect

Anxiety trials study generalized anxiety disorder, social anxiety, panic disorder and often post-traumatic stress alongside them. The treatments under study range from new medicines and repurposed ones to cognitive behavioral therapy delivered in person, by video or through an app, virtual-reality exposure, and brain stimulation. Many are run by universities and some can be completed largely online, with a small number of in-person visits.

In Massachusetts, recruiting anxiety studies are concentrated in Boston, Belmont, Cambridge and Lexington, with sites in 6 other cities. 3 of the 40 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who anxiety trials usually look for

Trials name the diagnosis they study and set a minimum symptom score on a standard questionnaire, confirmed by a clinician interview at screening. Adults 18 to 65 are the usual range, with separate studies for teenagers and older adults. Typical exclusions are bipolar disorder, psychosis, a current substance use disorder and, for some medicine trials, daily benzodiazepine use. Stable antidepressant treatment is often allowed.

What taking part involves

After a screening interview, medicine trials run eight to twelve weeks with visits every one to two weeks, questionnaires and sometimes blood work; placebo arms are common. Therapy trials involve weekly sessions for eight to sixteen weeks, often with a comparison group that gets the program later. Some studies add brain imaging or a wearable to track sleep and heart rate. Everything study-related is free, and most trials pay for your time.

Questions worth asking the study team

Which visits must be in person; whether you can continue your current medicine or therapy; the chance of placebo or of a waiting-list group; and what support is available if symptoms get worse during the study.

Showing 20 of 40 recruiting Anxiety trials in Massachusetts

Buspirone for Anxiety in Autistic Youth
PHASE4 Lexington, Massachusetts NCT07439042
This trial is looking for young people aged 7 to 17 with autism and anxiety. Participants will try a medication called buspirone to see if it helps with their anxiety symptoms.
Recruiting
Role of Parent Interpretation Bias in the Transmission of Anxiety to Children
NA Belmont, Massachusetts NCT05665491
This trial is looking for parents and children age 7 to 12 to understand how parents' views of anxiety may affect their children's feelings. Participants will complete assessments regarding anxiety and perception of situations.
Recruiting
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
PHASE3 Watertown, Massachusetts +4 sites NCT07767903
This trial is looking for adults with generalized anxiety disorder. Participants will take a daily dose of SEP-363856 or a placebo for 8 weeks while monitoring their response to the treatment.
Recruiting
A Study of NTX-1472 in Social Anxiety Disorder
PHASE2 Encino, California +4 sites NCT07323784
This trial is looking for adults with Social Anxiety Disorder. Participants will take a study treatment or a placebo every day for 8 weeks and attend 6 clinic visits for checkups and tests over 14 weeks.
Recruiting
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
PHASE2 Huntsville, Alabama +4 sites NCT06846320
This trial is looking for adults with generalized anxiety disorder (GAD) who have not had enough relief from their current antidepressant medications. Participants will take capsules of either ABBV-932 or a placebo for 6 weeks, along with their existing treatment, and attend regular check-up visits to monitor their progress.
Recruiting
Online Parent Education for Child Anxiety
NA Boston, Massachusetts NCT07153250
This trial is looking for parents of children ages 2-7 who are experiencing anxiety. Participants will complete a brief, online program to help manage their child's anxiety.
Recruiting
Reaching Calm: A Digital Intervention to Prevent Perinatal Anxiety Disorders
NA Leominster, Massachusetts NCT07458698
This trial is looking for pregnant women who may feel anxious. Participants will use a digital program to learn about anxiety and coping strategies, and share their experiences through surveys and interviews.
Recruiting
Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety
NA Boston, Massachusetts NCT05683223
This trial is looking for adults with social anxiety disorder who want to see if treatment will help them. Participants will undergo brain imaging and receive group therapy for 12 weeks, with the option for more therapy if needed.
Recruiting
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
NA Boston, Massachusetts +2 sites NCT04557891
This trial is looking for adults with generalized anxiety disorder who have not found relief from standard treatments. Participants will receive focused ultrasound treatment for their anxiety over four sessions.
Recruiting
Music Use in Parturients Admitted to Labor & Delivery
NA Boston, Massachusetts NCT06969105
This trial is looking for pregnant women who are in labor or scheduled to start labor. Participants will listen to music or no music for 10 minutes and share their feelings about anxiety, pain, and overall satisfaction with their care.
Recruiting
Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
NA Boston, Massachusetts NCT05567640
Recruiting
Oral Surgery Virtual Reality Glasses Study
NA Boston, Massachusetts NCT06723158
Recruiting
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
NA Boston, Massachusetts NCT05962879
This trial is looking for high school students aged 14 to 19 who have mild symptoms of depression, anxiety, or unusual feelings. Participants will take part in group sessions aimed at improving their mental health.
Recruiting
Pathways to Perinatal Mental Health Equity
NA Shrewsbury, Massachusetts NCT06790641
Recruiting
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
PHASE2 Lexington, Massachusetts NCT07812233
This trial is looking for autistic youth aged 12 to 17 who experience anxiety. Participants will use a wearable device that helps them manage their anxiety over 8 weeks.
Recruiting
On-Trac: An Online Intervention for Cancer Survivors Managing Anxiety
NA Boston, Massachusetts NCT07305740
This trial is looking for adult cancer survivors who are dealing with significant anxiety. Participants will engage in an online program to learn coping strategies based on proven therapy techniques.
Recruiting
Expressive Writing on Minority Stressors Among Sexual Minority Veterans
NA Boston, Massachusetts NCT05897021
This trial is looking for Veterans who identify as LGBTQ+ and are experiencing anxiety or depression. Participants will take part in a brief writing program over three sessions to help address their feelings related to stress from their minority identity.
Recruiting
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
NA Boston, Massachusetts NCT04912531
This trial is looking for adults having heart or lung surgery who want to try a new way to manage pain and anxiety. If you join, you may use virtual reality and scents to help with these feelings before and after surgery.
Recruiting
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
PHASE2 Belmont, Massachusetts NCT05457465
This trial is looking for adults aged 18 to 65 with bipolar disorder and anxiety. Participants will take a high-CBD product for 4 weeks to see if it helps with their anxiety.
Recruiting
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
PHASE4 Cambridge, Massachusetts NCT05649059
Recruiting
See all 40 Anxiety trials in Massachusetts

Where the Anxiety studies are in Massachusetts

Research sites running the most studies
  • Massachusetts General Hospital, Boston8 trials
  • McLean Hospital, Belmont3 trials
  • Beth Israel Deaconess Medical Center, Boston2 trials
  • Boston Children's Hospital, Boston2 trials
  • Boston University, Boston2 trials
  • Lurie Center, Lexington2 trials
By city

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

Anxiety clinical trials in Massachusetts: common questions

How many Anxiety clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 40 recruiting Anxiety clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Anxiety clinical trials located in Massachusetts?
Study sites for the Anxiety trials listed on this page include Lexington, Belmont, Watertown, Boston, Leominster, Shrewsbury. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Anxiety clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Anxiety trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Anxiety clinical trial in Massachusetts?
Each study sets its own criteria based on age, Anxiety diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I take part in an anxiety trial if I am already in therapy?
Often yes for medicine trials, if the therapy is ongoing and stable. Trials testing a therapy usually ask that you are not starting another one at the same time. The listing states its rule.
Are there anxiety studies I can do online?
Yes. Many app-based and video-therapy studies are mostly remote, though most still need one or two in-person visits, so distance to the site still matters.
Is there a placebo in anxiety trials?
Medicine trials usually include a placebo arm and say so in the consent form. Therapy trials compare against usual care or a group that receives the program after a delay.
Anxiety Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Anxiety Trials

Anxiety disorder trials study CBT approaches, novel anxiolytics, MDMA-assisted therapy, and neuromodulation techniques for GAD, social anxiety, and PTSD.

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