Clinical Trials
for Obesity in Massachusetts
52 clinical trials for Obesity are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.
Obesity clinical trials in Massachusetts: what to expect
Obesity trials are among the most actively recruiting studies in the United States right now. Most test medicines from the GLP-1 family (the class that includes semaglutide and tirzepatide) or newer compounds that work on the same appetite and blood-sugar pathways, often in people who also have high blood pressure, sleep apnea, knee osteoarthritis or prediabetes. A smaller number study structured diet and exercise programs, devices, or weight-loss surgery.
In Massachusetts, recruiting obesity studies are concentrated in Boston, New Bedford, Needham and Waltham, with sites in 8 other cities. 24 of the 52 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who obesity trials usually look for
Nearly every study sets a body mass index (BMI) threshold, most often 30 or higher, or 27 or higher when you also have a weight-related condition. Many ask that your weight has been stable for the last three months and that you are not currently using a prescription weight-loss drug. Age limits of 18 to 75 are common. Pregnancy, a history of pancreatitis or certain thyroid cancers, and bariatric surgery within the last few years are the exclusions that come up most.
If you have type 2 diabetes, look for trials that name it: some obesity studies exclude diabetes, while others are designed specifically for people who have both.
What taking part involves
A screening visit with a physical exam, blood work and an ECG usually comes first. Drug trials then run for six months to two years, with study visits every few weeks at the start and every one to three months later on. Most GLP-1 studies use a once-weekly injection you give yourself at home; many are placebo-controlled, meaning some participants receive an inactive version for part or all of the study, and you are told that before you agree to join. Study medication, visits and tests are provided at no cost, and most trials pay a stipend for time and travel.
Questions worth asking the study team
Whether there is a placebo group and how long it lasts; whether you can continue the medicine after the study ends; how many visits are required and how far the site is from you; and what happens if you need to stop early. Sites answer these every day and a ten-minute phone screen is the normal next step.
Showing 20 of 52 recruiting Obesity trials in Massachusetts
Where the Obesity studies are in Massachusetts
- Brigham and Women's Hospital, Boston8 trials
- Massachusetts General Hospital, Boston8 trials
- Lucida Clinical Trials, New Bedford5 trials
- Boston Children's Hospital, Boston4 trials
- Knownwell, Needham3 trials
- Brigham and Women's Hospital Diabetes Program, Boston2 trials
Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.
Obesity clinical trials in Massachusetts: common questions
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Get Matched — FreeObesity trials study GLP-1 receptor agonists, bariatric procedures, behavioural interventions, and combination weight-loss therapies in adults and adolescents.
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