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AZD6234 for Type 2 Diabetes and Obesity

A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

Recruiting Phase 3 Interventional Study
Obesity or Overweight Diabetes Mellitus, Type 2
More trials: Diabetes clinical trials· Diabetes trials in Alabama
Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
1,500 (estimated)
Sponsor
AstraZeneca · Industry
Who this trial is looking for

This trial is looking for adults with type 2 diabetes and obesity or being overweight. Participants will take AZD6234 or a placebo for 68 weeks to see how it affects their body weight.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am at least 18 years old
  • I have a body mass index (BMI) of 27 or higher
  • I have been diagnosed with type 2 diabetes for at least 90 days
  • My HbA1c value is between 6.0% and 10.0%
  • I have managed my diabetes with diet and exercise or stable medication
  • My body weight has been stable for at least the last 3 months
  • I have tried to lose weight unsuccessfully at least once in my lifetime

You may not be able to join if

  • I have obesity caused by other endocrine disorders
  • I have type 1 diabetes or another type of diabetes
  • I have experienced ketoacidosis or hyperosmolar coma in the last 3 months
  • I have significant liver disease or abnormal liver test results
  • I have taken a GLP-1 receptor agonist medication in the last 3 months
  • I have used insulin for my diabetes in the last 3 months

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment

Trial Locations

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Eligibility Criteria
Inclusion Criteria: * Males \& females (inclusive of all gender identities) age ≥18 years * BMI ≥27 kg/m2 * Diagnosed with T2DM ≥90 days prior to Screening * HbA1c value at Screening of ≥6.0% (42 mmol/mol) and ≤10% (86 mmol/mol) managed with diet and exercise alone or with a stable dose of any oral…
Contacts

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

CONTACT

NCT ID: NCT07784270 Source: ClinicalTrials.gov