No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 and older
Sex
Any
Study type
Observational
Participants needed
120 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for people diagnosed with Parkinson's Disease or healthy individuals without family history of the condition. Participants will undergo brain imaging to help researchers understand changes in brain connectivity related to Parkinson's.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's Disease
I do not have dementia
I have normal cognition
I do not have immediate family with Parkinson's Disease
You may not be able to join if
I have another neurological disorder
I have had a significant head injury with loss of consciousness
I have schizophrenia, bipolar disorder, or epilepsy
I have serious medical conditions like end-stage organ failure or ongoing cancer treatment
I have been diagnosed with dementia
I have conditions that prevent me from having an MRI
I weigh over 300 lbs
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is cri…
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Must meet specific health and cognitive criteria depending on the group. For PD participants
* Clinical diagnosis of Parkinson's Disease
* Must not meet dementia criteria For Healthy Control Participants
* Normal or benign neurological exam
* Normal cognition
* No first-degree…
Inclusion Criteria:
* Must meet specific health and cognitive criteria depending on the group. For PD participants
* Clinical diagnosis of Parkinson's Disease
* Must not meet dementia criteria For Healthy Control Participants
* Normal or benign neurological exam
* Normal cognition
* No first-degree relatives with Parkinson's Disease
Exclusion Criteria:
1. Neurological Disorders (other than PD)
\- Any other neurological condition
2. Significant Head Injury
* Head injury with loss of consciousness \>5 minutes
* Or any neurological sequelae
3. Psychiatric Disorders
* Schizophrenia
* Bipolar Disorder
* Epilepsy
4. Serious Medical Conditions
* End-stage organ failure
* Ongoing cancer treatment
5. Cognitive Impairment
* Diagnosis of dementia
* MMSE score \<24 or MoCA score \<21
6. MRI contraindications
* Metal implants
* claustrophobia
* Weight over 300 lbs (due to weight restrictions of the MRI scanner)
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.