Parkinson's Trials / Trials in Florida
41 Recruiting Trials

Clinical Trials
for Parkinson's in Florida

41 clinical trials for Parkinson's are currently recruiting participants at study sites in Florida. Study-related care is provided at no cost.

41
Recruiting trials
82
Study sites
28
Cities
25
Industry-sponsored
9
Phase 2
4
Phase 3

Parkinson's clinical trials in Florida: what to expect

Parkinson's trials fall into three groups. Disease-modifying studies test drugs meant to slow progression, including treatments aimed at alpha-synuclein, repurposed diabetes drugs and therapies for people with LRRK2 or GBA gene variants. Symptom studies test new ways to smooth out "off" periods and dyskinesia, and procedures such as focused ultrasound and deep brain stimulation. And a large number of studies involve no medicine: exercise, speech and balance programs, wearables, and long-term observational studies that track the disease.

In Florida, recruiting parkinson's studies are concentrated in Miami, Gainesville, Tampa and Boca Raton, with sites in 24 other cities. 25 of the 41 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Parkinson's trials usually look for

Disease-modifying trials usually enroll people diagnosed in the last two to five years, sometimes before any Parkinson's medicine has started. Symptom trials want people on levodopa who have a stated number of hours of "off" time a day. Most set ages 30 to 80, exclude dementia and atypical parkinsonism, and may require a dopamine transporter scan to confirm the diagnosis. Genetic trials test for the variant at no cost. Exercise and observational studies accept a much wider range.

What taking part involves

Screening includes a movement exam, sometimes performed both before and after your morning dose, blood work and a scan. Drug trials run twelve weeks to two years with monthly visits, symptom diaries and, in some, a spinal fluid test. Placebo arms are common and medicines you already take generally continue. Exercise and rehabilitation trials involve sessions two or three times a week for several months. Everything study-related is free and travel is usually reimbursed; a care partner is welcome and sometimes required.

Questions worth asking the study team

Whether you must skip a dose before visits; whether your current medicines continue; what the chance of placebo is and whether an extension follows; how many visits are required; and whether you will be told the results of any scans or genetic tests.

Showing 20 of 41 recruiting Parkinson's trials in Florida

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
PHASE3 Birmingham, Alabama +4 sites NCT07174310
This trial is looking for people with early-stage Parkinson's disease who are currently on stable treatment with levodopa. Participants will receive either the drug prasinezumab or a placebo to study its effects.
Recruiting
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
PHASE1 Naples, Florida +4 sites NCT06565195
This trial is looking for healthy volunteers and patients with Parkinson's disease to evaluate the safety and effects of a drug called LY3962681. Participants will receive either the drug or an inactive substance and will be followed up for medical assessments over time.
Recruiting
Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners
NA Coral Springs, Florida +2 sites NCT06581523
This trial is looking for people with early-stage Parkinson's Disease and their caregivers. Participants will learn a specific breathwork and meditation technique over four days and practice it daily for four weeks.
Recruiting
Parkinson's Foundation PD GENEration Genetic Registry
N/A Birmingham, Alabama +4 sites NCT04994015
This trial is looking for people with Parkinson's disease who are willing to undergo genetic testing. Participants will help build a genetic database for future research on the condition.
Recruiting
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
N/A Phoenix, Arizona +4 sites NCT07330258
This trial is looking for people with Parkinson's disease who still have movement symptoms even though they are on medication. Participants will help researchers understand how the condition changes over time without altering their current treatment.
Recruiting
A Study of Buntanetap in Participants With PD
PHASE2 Birmingham, Alabama +4 sites NCT07284784
This trial is looking for adults with Parkinson's Disease who are either already on deep brain stimulation treatment or have participated in earlier trials with buntanetap. Participants will take the medication for 36 months and attend regular check-ups.
Recruiting
A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease
PHASE3 Scottsdale, Arizona +4 sites NCT06944522
This trial is looking for adults with Parkinson's Disease who are between 45 and 75 years old. Participants will receive a treatment called bemdaneprocel to see how well it works and if it is safe.
Recruiting
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
PHASE4 Tucson, Arizona +4 sites NCT04373317
This trial is looking for veterans aged 40 or older who have Parkinson's disease and experience symptoms like hallucinations or delusions. Participants will take either Pimavanserin or Quetiapine, and will need to attend study visits regularly.
Recruiting
Electrophysiology-based DBS Programming for PD
NA Gainesville, Florida NCT07348705
This trial is looking for people with Parkinson's disease to see if a new way of programming deep brain stimulation can help them better. Participants will have deep brain stimulation already in place and will take part during their first programming session.
Recruiting
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease
N/A Miami, Florida +4 sites NCT04991831
This trial is looking for adults with tremors from Parkinson's disease. Participants will undergo a specific procedure to see how safe and effective it is over time.
Recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
N/A Gainesville, Florida +4 sites NCT02071134
This trial is looking for adults with Parkinson’s disease to evaluate a device called the Vercise DBS System. Participants will help gather information on the device's effectiveness in treating their condition.
Recruiting
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
PHASE2 Sun City, Arizona +4 sites NCT06680830
This trial is looking for men and women aged 40-80 who have early Parkinson's Disease and a specific genetic profile. Participants will take part in a study to evaluate the safety and effectiveness of a new treatment called NEU-411.
Recruiting
SAD Study in Patients With Parkinson's Disease and Motor Fluctuations
PHASE1 Hallandale, Florida +4 sites NCT07422675
This trial is looking for people with Parkinson's disease who experience motor fluctuations. Participants will receive a single dose of the medication SER-252 and will be monitored for safety and effectiveness.
Recruiting
Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease
NA Gainesville, Florida +3 sites NCT07207122
This trial is looking for adults with Parkinson's disease to test a new treatment called transcranial focused ultrasound. Participants will receive the treatment and be monitored for safety and effectiveness.
Recruiting
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
NA Gainesville, Florida +1 sites NCT07674264
This trial is looking for adults with Parkinsonism to test if a special breathing treatment can help improve their breathing and movement. Participants will try one session of this treatment and share how it affects them.
Recruiting
A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease
PHASE2 Birmingham, Alabama +4 sites NCT06976268
This trial is looking for adults aged 40 to 80 with early Parkinson's disease. Participants will receive treatment over 48 weeks, followed by another 48 weeks of open access to the treatment.
Recruiting
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
PHASE2 Little Rock, Arkansas +4 sites NCT07432958
This trial is looking for people with Parkinson's disease who have motor fluctuations while taking their medication. Participants will receive either the study drug AP-472 or a placebo for about 12 weeks to see how well it works.
Recruiting
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease
PHASE2 Gainesville, Florida +4 sites NCT07005180
This trial is looking for people between the ages of 40 and 80 who have been diagnosed with Parkinson's disease and have been using a specific Parkinson's medication for at least a month. It’s important that they haven’t smoked in the last five years and that they are generally in good health. Also, they need to have someone at home who can help keep an eye on them after taking the medication.
Recruiting
Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease
PHASE2 Davie, Florida +3 sites NCT05266417
This trial is looking for people with Parkinson's Disease to test the safety and effectiveness of a new treatment involving insulin and glutathione. Participants will need to take part in the study for some time and will continue their usual diet and medications.
Recruiting
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
PHASE2 Phoenix, Arizona +4 sites NCT06285643
This trial is looking for adults aged 45-75 with moderate Parkinson's disease. Participants will receive a treatment involving a surgical procedure and will be monitored for safety and effectiveness.
Recruiting
See all 41 Parkinson's trials in Florida

Where the Parkinson's studies are in Florida

Research sites running the most studies
  • University of Florida, Gainesville9 trials
  • University of Miami, Miami4 trials
  • University of South Florida, Tampa4 trials
  • University of Miami Hospital, Miami3 trials
  • Aqualane Clinical Research, Naples2 trials
  • Charter Research, The Villages2 trials
By city

Counts are recruiting studies listing at least one site in Florida, from ClinicalTrials.gov, refreshed every two days.

Parkinson's clinical trials in Florida: common questions

How many Parkinson's clinical trials are recruiting in Florida?
TrialFinder currently lists 41 recruiting Parkinson's clinical trials with study sites in Florida. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Parkinson's clinical trials located in Florida?
Study sites for the Parkinson's trials listed on this page include Naples, Coral Springs, Gainesville, Miami, Hallandale, Davie. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Parkinson's clinical trial in Florida?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Parkinson's trials in Florida also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Parkinson's clinical trial in Florida?
Each study sets its own criteria based on age, Parkinson's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a Parkinson's trial if I take carbidopa-levodopa?
Yes for most trials, including every study of "off" time. Some disease-modifying trials want people who have not started medicine yet; the listing says so.
What does "off time" mean in a trial listing?
The hours each day when your medicine has worn off and symptoms return. Trials of new symptom treatments usually require about two or more hours of off time a day, recorded in a diary during screening.
Are there Parkinson's trials that do not involve medicine?
Many. Exercise, speech, balance and dance programs, wearable sensors, deep brain stimulation settings and observational studies all recruit, and most accept people at any stage who can attend sessions.
Parkinson's Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Parkinson's Trials

Parkinson's disease trials test dopamine-replacement therapies, deep brain stimulation, gene therapies, and neuroprotective compounds to slow disease progression.

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