Hypertension Trials / Trials in Maryland
33 Recruiting Trials

Clinical Trials
for Hypertension in Maryland

33 clinical trials for Hypertension are currently recruiting participants at study sites in Maryland. Study-related care is provided at no cost.

33
Recruiting trials
36
Study sites
15
Cities
9
Industry-sponsored
4
Phase 2
7
Phase 3

Hypertension clinical trials in Maryland: what to expect

High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.

In Maryland, recruiting hypertension studies are concentrated in Baltimore, Bethesda, Columbia and Ft. Washington, with sites in 11 other cities. 9 of the 33 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who hypertension trials usually look for

Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.

What taking part involves

Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.

Showing 20 of 33 recruiting Hypertension trials in Maryland

Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes
NA Baltimore, Maryland NCT06921356
This trial is looking for adults who have high blood pressure and type 2 diabetes. Participants will receive help to eat healthier and manage their weight over a 6-month period.
Recruiting
Addressing Hypertension Care in Africa Program
NA Baltimore, Maryland +4 sites NCT06986590
This trial is looking for adults aged 18 to 70 with high blood pressure. Participants will be involved in a program designed to help manage their condition and improve heart health.
Recruiting
Childhood-Onset Essential Hypertension Natural History Study
N/A Bethesda, Maryland NCT06778239
This trial is looking for children and teens with high blood pressure, as well as healthy family members. Participants will visit a clinic once a year for health check-ups and may provide blood and urine samples for research.
Recruiting
Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects
PHASE4 Baltimore, Maryland +3 sites NCT04401982
This trial is looking for adults with ocular hypertension or suspects of glaucoma. Participants will receive treatment with either latanoprost or Rocklatan and undergo several eye tests before, during, and after treatment.
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
PHASE3 Phoenix, Arizona +4 sites NCT07218029
This trial is looking for people who have completed a previous study with sotatercept for pulmonary arterial hypertension (PAH). Participants will be monitored for the long-term safety and tolerance of sotatercept along with their usual PAH treatments.
Recruiting
Spironolactone for Pulmonary Arterial Hypertension
PHASE2 Bethesda, Maryland NCT01712620
This trial is looking for adults with pulmonary arterial hypertension (PAH). Participants will take either the drug spironolactone or a placebo for 24 weeks to see if it helps improve their condition.
Recruiting
Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
PHASE2 Baltimore, Maryland +2 sites NCT06992440
This trial is looking for adults with pulmonary arterial hypertension (PAH) who have problems with the right side of their heart. Participants will take either the study drug empagliflozin or a placebo while continuing their current PAH treatment.
Recruiting
Pulmonary Hypertension (PH) Biorepository for Translational Research
N/A Baltimore, Maryland +2 sites NCT07647549
Recruiting
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
N/A Birmingham, Alabama +4 sites NCT06388421
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Recruiting
Pulmonary Hypertension Association Registry
N/A Phoenix, Arizona +4 sites NCT04071327
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NA Scottsdale, Arizona +4 sites NCT06059638
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Recruiting
Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women
NA Baltimore, Maryland NCT07042386
This trial is looking for Black or Hispanic women with high blood pressure. Participants will get blood pressure screenings at beauty salons and receive support for managing their health.
Recruiting
Integrating Free-choice Marketplace, dieTitian coacHing, cultuRally Tailored messagIng to improVE Blood Pressure
NA Baltimore, Maryland +2 sites NCT07075588
This trial is looking for adults aged 21 to 70 who identify as Black or Hispanic and have high blood pressure. Participants will receive support through digital tools and coaching to help manage their blood pressure.
Recruiting
A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities
NA Baltimore, Maryland +2 sites NCT05321368
This trial is looking for adults with high blood pressure and either diabetes or chronic kidney disease. Participants will use a home blood pressure monitor and get support from healthcare providers to manage their conditions better.
Recruiting
An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.
PHASE2 Garden Grove, California +4 sites NCT07543120
This trial is looking for patients with high blood pressure who have completed an earlier study with the QCZ484 medication. Participants will continue to take QCZ484 and help researchers gather more information on its safety and effectiveness.
Recruiting
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
PHASE3 Fairhope, Alabama +4 sites NCT06742723
This trial is looking for adults with chronic kidney disease and high blood pressure. If you join, you will take medications to see how they affect your kidney health and heart-related risks.
Recruiting
Clarifying the Optimal Application of SLT Therapy Trial
PHASE3 Laguna Hills, California +4 sites NCT04967989
This trial is looking for people with glaucoma or high eye pressure. Participants will receive a special eye treatment to see how effective it is at different energy levels.
Recruiting
Study of Intravenous ZMA001 in Healthy Subjects
PHASE1 Bethesda, Maryland NCT05967299
This trial is looking for healthy adults aged 18 to 60 years. Participants will receive a single dose of a study drug called ZMA001 or a placebo during a hospital stay lasting up to 48 hours.
Recruiting
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
PHASE3 Birmingham, Alabama +4 sites NCT07181109
This trial is looking for adults with high blood pressure that is not well controlled and have either a history of heart disease or are at high risk for heart disease. Participants will receive either the study drug, zilebesiran, or a placebo to see if it lowers the risk of serious heart-related events.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
See all 33 Hypertension trials in Maryland

Where the Hypertension studies are in Maryland

Research sites running the most studies
  • National Institutes of Health Clinical Center, Bethesda9 trials
  • Johns Hopkins University, Baltimore3 trials
  • University of Maryland Medical Center, Baltimore3 trials
  • Anderson Medical Research, Ft. Washington2 trials
  • Johns Hopkins Community Physicians, Baltimore2 trials
  • Ascension Saint Agnes Heart Care, Baltimore1 trial
By city

Counts are recruiting studies listing at least one site in Maryland, from ClinicalTrials.gov, refreshed every two days.

Hypertension clinical trials in Maryland: common questions

How many Hypertension clinical trials are recruiting in Maryland?
TrialFinder currently lists 33 recruiting Hypertension clinical trials with study sites in Maryland. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Maryland?
Study sites for the Hypertension trials listed on this page include Baltimore, Bethesda. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Maryland?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Maryland also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Maryland?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Hypertension Trials

Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.

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