No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 35
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
44 (estimated)
Sponsor
Mayo Clinic · Other
Who this trial is looking for
This trial is looking for healthy adults between 18 and 35 years old to study how limited sleep affects blood pressure. Participants will have their sleep and health monitored during the study.
Are You a Good Fit for This Trial?
Must not be takingMelatoninOver-the-counter sleep aids
Rules you outModerate-to-severe insomniaRestless leg syndrome
You may be able to join if
I am a healthy adult aged 18-35 years
I do not have significant medical or psychiatric issues
I do not smoke
I am not pregnant
I usually sleep 7-9 hours per night without naps
I know my biological parents' blood pressure history
I can understand and follow study instructions
I can speak English and give informed consent
You may not be able to join if
I am under 18 or over 35 years old
My body mass index is below 18.5 or above 30
I am pregnant or breastfeeding
I use tobacco, marijuana, or other drugs
I drink more than 400 mg of caffeine per day
I have high blood pressure (above 130/80 mmHg)
I have a history of significant medical or psychiatric disorders
I suffer from excessive daytime sleepiness
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria
* Healthy adults aged 18-35 years
* Absence of any significant medical or psychiatric disease (as per the investigators' judgment)
* Nonsmoker
* Nonpregnant
* History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping)
* Hype…
Inclusion Criteria
* Healthy adults aged 18-35 years
* Absence of any significant medical or psychiatric disease (as per the investigators' judgment)
* Nonsmoker
* Nonpregnant
* History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping)
* Hypertension status information available for both biological parents
* Ability to understand study procedures and to comply with them for the entire length of the study
* Ability to understand English and provide informed consent
Exclusion Criteria
* Age \<18 or \>35 years
* Body mass index \<18.5 or ≥30 kg/m2
* Pregnant or lactating
* Unable to determine history of HTN in participant's biological parents or subject being adopted
* Use of tobacco, vaping, marijuana products or other drugs
* Excessive caffeine consumption (\>400 mg/day)
* Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men)
* Office SBP/DBP ≥130/80 mmHg
* Daytime ambulatory SBP/DBP ≥130/80 mmHg
* Fasting glucose ≥126 mg/dl
* Glomerular filtration rate \<60 mL/min/BSA
* History of significant medical or psychiatric disorders (as per the investigators' judgment)
* Regular use of prescription medications other than contraceptives
* Use of melatonin supplements or any other over-the-counter sleep aid
* Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10)
* Moderate-to-severe insomnia (Insomnia Severity Index \>14)
* Restless leg syndrome (as per the Cambridge-Hopkins questionnaire)
* Excessive daytime sleepiness (Epworth Sleepiness Scale \>15)
* Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31)
* Night shift work
* Ongoing participation in other research studies (as per the investigators' judgment)
* Any other medical, geographic, or social factor making study participation impractical
* Not English-speaking and/or inability to provide informed consent
* Exclusionary for blood draws: hemoglobin \<11.6 g/dL in women / \<13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.
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