COPD Trials / Trials in Alabama
20 Recruiting Trials

Clinical Trials
for COPD in Alabama

20 clinical trials for COPD are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

20
Recruiting trials
22
Study sites
9
Cities
13
Industry-sponsored
6
Phase 2
7
Phase 3

COPD clinical trials in Alabama: what to expect

COPD trials test new inhaler combinations, biologic injections for people whose flare-ups continue despite inhalers, and treatments for the cough and mucus that come with chronic bronchitis. Others study pulmonary rehabilitation and exercise, valves and other procedures for emphysema, home oxygen and remote monitoring, and programs to stop smoking. Most enroll people with moderate to severe disease who still have symptoms on their current treatment.

In Alabama, recruiting copd studies are concentrated in Birmingham, Mobile, Sheffield and Cullman, with sites in 5 other cities. 13 of the 20 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COPD trials usually look for

Trials confirm COPD with a breathing test at screening and set a range for lung function, usually between 30 and 80 percent of predicted. Most ask for a smoking history of at least ten pack-years, though current smokers are generally accepted. Biologic trials require one or two flare-ups in the past year needing steroids or antibiotics and sometimes a blood eosinophil count above a threshold. Common exclusions are asthma as the main diagnosis, another significant lung disease and a flare-up in the past four weeks. Ages are usually 40 to 80.

What taking part involves

Screening includes spirometry, blood work and a symptom questionnaire, then a short run-in while you record symptoms. Drug trials run six to twelve months with visits every four to twelve weeks, breathing tests, a six-minute walk in some, and a diary or app. Your maintenance inhalers continue, sometimes replaced by study-supplied versions, and rescue inhaler is always allowed. Rehabilitation trials involve two or three sessions a week for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your inhalers stay the same; how breathing tests and walking tests are scheduled; the chance of placebo; what to do during a flare-up while enrolled; and whether oxygen users are accepted.

Showing 20 of 20 recruiting COPD trials in Alabama

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
PHASE2 Birmingham, Alabama +2 sites NCT05270525
This trial is looking for people with COPD who smoke or have a history of smoking. Participants will take either ensifentrine or a placebo for two 8-week periods and attend several clinic visits over 24 weeks.
Recruiting
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
NA Birmingham, Alabama +3 sites NCT07222410
This trial is looking for people with COPD who are in the hospital and need extra oxygen. Participants will use the Airvo 3 device to help keep their oxygen levels stable.
Recruiting
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
NA Birmingham, Alabama +4 sites NCT07051707
This trial is looking for adults with chronic obstructive pulmonary disease (COPD) who have been receiving standard medical care. Participants will undergo a one-time procedure to help improve their breathing.
Recruiting
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NA Birmingham, Alabama +4 sites NCT05204888
This trial is looking for people with moderate to very severe COPD who have had a recent severe worsening of their condition. Participants will use the myAirvo 3 device at home while receiving their usual COPD care for at least one year.
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
PHASE3 Birmingham, Alabama +4 sites NCT06878261
This trial is looking for adults aged 40 to 80 who have had COPD for at least a year. Participants will take the study drug Tezepelumab and be monitored for its effects on their condition.
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
PHASE3 Foley, Alabama +4 sites NCT06883305
This trial is looking for adults with moderate to very severe COPD. Participants will be required to take part in assessments and treatments involving Tezepelumab.
Recruiting
Multi-Center Clean Air Randomized Controlled Trial in COPD
PHASE3 Birmingham, Alabama +4 sites NCT06376994
This trial is looking for people with chronic obstructive pulmonary disease (COPD) to see if using an air cleaner can help them. Participants will be asked questions about their health and will have an air cleaner placed in their home to test its effectiveness.
Recruiting
Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD
PHASE2 Birmingham, Alabama +4 sites NCT07059091
This trial is looking for individuals with Chronic Obstructive Pulmonary Disease (COPD) and allergies. Participants will take a medication called omalizumab for about a year and have follow-up calls afterwards.
Recruiting
SPIROMICS Study of Early COPD Progression (SOURCE)
N/A Birmingham, Alabama +4 sites NCT05033990
This trial is looking for people aged 30-55 to study early chronic obstructive pulmonary disease (COPD). Participants will undergo tests like breathing tests and provide samples to help researchers understand who is at risk of developing COPD.
Recruiting
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
NA Birmingham, Alabama +4 sites NCT06891755
This trial is looking for adults with COPD and emphysema who experience difficulty breathing. Participants will receive a device to help open their airways and will be followed for three years.
Recruiting
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
PHASE3 Athens, Alabama +4 sites NCT06283966
This trial is looking for adults aged 40 to 80 with Chronic Obstructive Pulmonary Disease (COPD). Participants will receive a combination inhaler treatment and attend study visits for assessments.
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07082738
This trial is looking for people with moderate to very severe COPD to test the effects of a new drug called AZD6793. Participants will take AZD6793 or a placebo and help researchers learn about its safety and effectiveness.
Recruiting
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
PHASE3 Sheffield, Alabama +4 sites NCT06961214
This trial is looking for adults with moderate to severe COPD and type 2 inflammation. Participants will be taking depemokimab as an additional treatment along with their current medications.
Recruiting
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
PHASE3 Birmingham, Alabama +4 sites NCT07190222
This trial is looking for adults aged 40 to 80 with chronic obstructive pulmonary disease (COPD) that is not well controlled. Participants will receive either lunsekimig or a placebo for about 48 weeks, followed by an 8-week follow-up.
Recruiting
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07363694
This trial is looking for adults aged 35 to 80 with moderate to severe COPD. Participants will receive either the study medicine PF-07275315 or a placebo through shots over 24 to 68 weeks and will attend multiple clinic visits during this time.
Recruiting
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
PHASE2 Mobile, Alabama +4 sites NCT07610395
This trial is looking for people with COPD who have had recent respiratory infections. Participants will take a medication called vapendavir to see if it helps reduce their cold symptoms.
Recruiting
A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
PHASE2 Birmingham, Alabama +4 sites NCT07759245
This trial is looking for adults with moderate-to-severe COPD to test a new treatment called Brenipatide. Participants will receive either the treatment or a placebo and will be monitored for about one year.
Recruiting
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
PHASE4 Birmingham, Alabama NCT07135427
This trial is looking for adults who have a specific genetic mutation related to alpha 1 antitrypsin deficiency. Participants will receive a pneumonia vaccine and scientists will observe their immune responses based on their history of COPD flare-ups over the past year.
Recruiting
Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities
N/A Birmingham, Alabama NCT07748858
This trial is looking for people who are at least 50 years old and have heart issues, like high blood pressure or heart failure, along with at least one other ongoing health problem, such as diabetes or arthritis. It cannot accept anyone with serious mental health conditions or who lives in a nursing home.
Recruiting
PiMZ Longitudinal Cohort (PiMZ Logic)
N/A Birmingham, Alabama +4 sites NCT06505603
This trial is looking for adults with a specific genetic condition called PiMZ alpha-1 antitrypsin deficiency who have breathing problems. Participants will undergo lung scans and provide health information to help understand their condition better.
Recruiting
See all 20 COPD trials in Alabama

Where the COPD studies are in Alabama

Research sites running the most studies
  • University of Alabama at Birmingham, Birmingham6 trials
  • Research Site, Mobile2 trials
  • Research Site, Sheffield2 trials
  • Research Site, Birmingham2 trials
  • Research Site, Cullman2 trials
  • Cooper Green Mercy Hospital, Birmingham1 trial
By city

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

COPD clinical trials in Alabama: common questions

How many COPD clinical trials are recruiting in Alabama?
TrialFinder currently lists 20 recruiting COPD clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COPD clinical trials located in Alabama?
Study sites for the COPD trials listed on this page include Birmingham, Foley, Athens, Sheffield, Mobile. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COPD clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COPD trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COPD clinical trial in Alabama?
Each study sets its own criteria based on age, COPD diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to quit smoking to join a COPD trial?
Most COPD trials accept current smokers; some require that you have stopped, and smoking-cessation trials are specifically for people who still smoke. The listing states the rule.
What tests confirm COPD for a trial?
Spirometry, a breathing test done at the site before and after a bronchodilator, which gives the lung function figure trials use to set their range. You do not need recent results to ask.
Will I keep using my inhalers during a trial?
Yes. Trials add the study treatment to your maintenance inhalers or supply a standardized equivalent, and a rescue inhaler is always permitted.
COPD Trials in Other States
Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to COPD trials near you in Alabama.

Get Matched — Free
No insurance required
About COPD Trials

COPD trials investigate bronchodilators, anti-inflammatory biologics, pulmonary rehabilitation, and lung-volume reduction procedures for chronic obstructive lung disease.

All COPD trials →
Other Conditions in Alabama
Diabetes Cancer Breast Cancer Depression Anxiety Alzheimer's Heart Disease Asthma Multiple Sclerosis Obesity Parkinson's Lupus Hypertension Stroke Arthritis Kidney Disease COVID-19
All trials in Alabama →