Alzheimer's Trials / Trials in Alabama
11 Recruiting Trials

Clinical Trials
for Alzheimer's in Alabama

11 clinical trials for Alzheimer's are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

11
Recruiting trials
9
Study sites
3
Cities
6
Industry-sponsored
4
Phase 2
6
Phase 3

Alzheimer's clinical trials in Alabama: what to expect

Alzheimer's trials now span the whole course of the disease. Prevention studies enroll people with normal memory who have early signs of amyloid in the brain; treatment studies enroll people with mild cognitive impairment or early Alzheimer's and test the next generation of antibodies, tau-targeting drugs and combinations; and symptom studies address agitation, sleep and depression in later stages. Alongside drugs there are trials of exercise, cognitive training, blood tests for diagnosis and support programs for care partners.

In Alabama, recruiting alzheimer's studies are concentrated in Birmingham, Homewood and Huntsville. 6 of the 11 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Alzheimer's trials usually look for

Most drug trials enroll ages 50 to 85 and define a stage with a memory test score range, then confirm Alzheimer's with an amyloid PET scan, a spinal fluid test or, increasingly, a blood test, all done by the study. Nearly every trial requires a study partner: someone who knows you well, attends visits and answers questions about daily life. Common exclusions are another cause of memory loss, a recent stroke and, for antibody trials, some blood thinners or MRI findings. Prevention trials enroll people with no symptoms at all.

What taking part involves

Screening is longer than for most conditions, often several visits over a few weeks with memory testing, an MRI and an amyloid test. Antibody trials then involve an infusion or injection every two to four weeks, regular safety MRIs and visits for eighteen months to four years, with an extension in which everyone receives the drug. Lifestyle trials involve classes or coaching for six to twenty-four months. All study care is free and travel is usually reimbursed for you and your partner.

Questions worth asking the study team

Whether you will be told your amyloid or genetic results; what the MRI safety monitoring involves; how much time the study partner must give; whether there is an extension after the placebo period; and what happens if memory worsens during the study.

Showing 11 of 11 recruiting Alzheimer's trials in Alabama

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
PHASE3 Birmingham, Alabama +4 sites NCT07177352
This trial is looking for individuals who may qualify for Alzheimer's disease research studies. Participants will be assessed to see if they can join related interventional studies.
Recruiting
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
PHASE3 Homewood, Alabama +4 sites NCT05980949
This trial is looking for people who have completed previous studies on KarXT for Alzheimer's-related psychosis. Participants will take KarXT for a year to help researchers understand its long-term safety and tolerability.
Recruiting
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
PHASE3 Homewood, Alabama +4 sites NCT05511363
This trial is looking for older adults with psychosis associated with Alzheimer's Disease. Participants will be randomly assigned to receive either KarXT or a placebo for 38 weeks, with regular visits to monitor their condition.
Recruiting
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
PHASE3 Birmingham, Alabama +4 sites NCT07169578
This trial is looking for people with early Alzheimer's disease symptoms. Participants will take part in tests to evaluate their memory and cognitive abilities while receiving treatment.
Recruiting
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
PHASE2 Birmingham, Alabama +4 sites NCT05552157
This trial is looking for adults aged 18 and older who have a specific genetic mutation linked to early Alzheimer's disease or have a family history of it, but are not showing any signs of cognitive decline yet. They also ask that women who could become pregnant use effective birth control during the study. If someone has significant health issues or cannot communicate in the approved language, they won’t be able to participate.
Recruiting
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
PHASE2 Birmingham, Alabama +4 sites NCT06647498
This trial is looking for adults at risk for Alzheimer's disease caused by genetic mutations. If eligible, I will take a study drug and undergo various tests to help assess its effects on the disease.
Recruiting
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
PHASE2 Homewood, Alabama +4 sites NCT06808984
This trial is looking for people with Alzheimer's disease who experience agitation. Participants will take a medication called BMS-986368 and help researchers understand its effects.
Recruiting
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
PHASE2 Birmingham, Alabama NCT03503331
This trial is looking for people who are part of the UAB Alzheimer's Disease Center study. Participants will help researchers measure brain changes related to Alzheimer's using special imaging techniques.
Recruiting
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
PHASE1 Birmingham, Alabama NCT03809351
This trial is looking for participants to help researchers measure tau levels in the brain of individuals with Alzheimer’s disease. Participants will also be involved in another study that checks for amyloid levels and cognitive status.
Recruiting
A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease
N/A Huntsville, Alabama NCT06566170
This trial is looking for people with early Alzheimer's disease to see if the drug donanemab works better with usual care than just usual care alone. Participants will engage in regular visits and share their health data over about 273 weeks.
Recruiting
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
NA Huntsville, Alabama NCT07146412
This trial is looking for older adults who have a family history of dementia and want to learn more about their own risk. Participants will take part in assessments and complete surveys while learning about lifestyle changes that may help reduce their risk of dementia.
Recruiting
See all 11 Alzheimer's trials in Alabama

Where the Alzheimer's studies are in Alabama

Research sites running the most studies
  • Local Institution - 1029, Homewood2 trials
  • University of Alabama at Birmingham, Birmingham2 trials
  • University of Alabama in Birmingham, Birmingham2 trials
  • Local Institution - 0046, Homewood1 trial
  • Rehabilitation & Neurological Services, Huntsville1 trial
  • Smith Family Clinic for Genomic Medicine, Huntsville1 trial
By city

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

Alzheimer's clinical trials in Alabama: common questions

How many Alzheimer's clinical trials are recruiting in Alabama?
TrialFinder currently lists 11 recruiting Alzheimer's clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Alzheimer's clinical trials located in Alabama?
Study sites for the Alzheimer's trials listed on this page include Birmingham, Homewood, Huntsville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Alzheimer's clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Alzheimer's trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Alzheimer's clinical trial in Alabama?
Each study sets its own criteria based on age, Alzheimer's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need an Alzheimer's diagnosis to join a trial?
No. Prevention trials enroll people with normal memory and test them for early amyloid, and many treatment trials accept people with memory concerns who have not been formally diagnosed, then confirm the diagnosis as part of screening.
What is a study partner?
A family member or close friend who attends visits with you and answers questions about memory and daily activities. Nearly every Alzheimer's trial requires one, and their time is usually reimbursed too.
Will I learn my amyloid or APOE results?
Many trials now disclose amyloid status, since it decides eligibility, and explain what it means. Genetic results are disclosed in some trials and not others; ask before you consent.
Alzheimer's Trials in Other States
Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Alzheimer's Trials

Alzheimer's disease trials test amyloid-clearing antibodies, tau inhibitors, lifestyle interventions, and early-detection biomarkers for dementia prevention and treatment.

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