No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
65 – 75
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
200 (estimated)
Sponsor
HudsonAlpha Institute for Biotechnology · Other
Who this trial is looking for
This trial is looking for older adults who have a family history of dementia and want to learn more about their own risk. Participants will take part in assessments and complete surveys while learning about lifestyle changes that may help reduce their risk of dementia.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 65 and 75 years old.
I have a family member who has had dementia.
I scored over 24 on the Montreal Cognitive Assessment.
I can understand and sign documents for the study.
I can perform physical tests required by the study.
I have access to a computer, tablet, or smartphone with internet.
I can complete surveys and assessments in English.
You may not be able to join if
I have been diagnosed with any type of cognitive impairment.
I am currently pregnant.
I am under 19 years old.
I do not speak and write in English fluently.
I have a serious illness that would affect my participation.
I have been hospitalized in the last 3 months.
I have severe hearing or visual impairment affecting study tasks.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more effective when started early. Previous studies have shown that multimodal lifestyle interventions can significantly delay the onset of Alzheimer's dementia in individuals w…
Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more effective when started early. Previous studies have shown that multimodal lifestyle interventions can significantly delay the onset of Alzheimer's dementia in individuals with high risk for Alzheimer's or with Mild Cognitive Impairment (MCI). These interventions may be less effective when initiated after dementia has already been diagnosed or is more advanced.
This study has two primary goals. The first goal is to assess attitudes around dementia risk for participants throughout the study as they learn of their personalized risk and possible lifestyle factors that may modify that risk. The second goal is to serve as a logistical pilot for the implementation of data collection and processing and multimodal lifestyle intervention to reduce the risk factors of dementia in individuals without current cognitive impairment but who are at high risk of progression to dementia. Secondary goals of this study include better defining what factors contribute the most risk to dementia and identifying sub-types of dementia defined by different genetic and molecular risk factors.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Adults 65-75 years of age at enrollment with at least one self-reported 1st-degree relative who had or has any kind of dementia
* Montreal Cognitive Assessment (MoCA) score \> 24 at initial enrollment
* Able and willing to comprehend and sign the informed consent document
* Ab…
Inclusion Criteria:
* Adults 65-75 years of age at enrollment with at least one self-reported 1st-degree relative who had or has any kind of dementia
* Montreal Cognitive Assessment (MoCA) score \> 24 at initial enrollment
* Able and willing to comprehend and sign the informed consent document
* Able and willing to perform required physical performance tests
* Able and willing to provide the study's minimum samples
* Able and willing to conduct the study's minimum procedures
* Able and willing to complete surveys, cognitive assessments, and questionnaires in English only
* Has or has ready access to a PC, tablet, or smartphone with an internet connection required for procedures that they consent to
Exclusion Criteria:
* A diagnosis of cognitive impairment of any kind, including Alzheimer's disease, mild cognitive impairment, or any other diagnosis of dementia
* If a subject is found to have cognitive impairment at initial enrollment (Montreal Cognitive Assessment (MoCA) score\<25), they will be excluded from the study
* Self-reported pregnancy
* Children under 19 years of age
* Individuals not fluent in written and spoken English
* Self-reported chronic or end-stage disease that would interfere with their participation in the study
* Hospitalization for any reason in the past 3 months
* Severe hearing and visual impairment that would interfere with the ability to complete study measures
* Any other vulnerable subject at the time of enrollment as specified above
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.
