Alzheimer's Trials / Trials in South Carolina
8 Recruiting Trials

Clinical Trials
for Alzheimer's in South Carolina

8 clinical trials for Alzheimer's are currently recruiting participants at study sites in South Carolina. Study-related care is provided at no cost.

8
Recruiting trials
7
Study sites
4
Cities
7
Industry-sponsored
2
Phase 2
6
Phase 3

Alzheimer's clinical trials in South Carolina: what to expect

Alzheimer's trials now span the whole course of the disease. Prevention studies enroll people with normal memory who have early signs of amyloid in the brain; treatment studies enroll people with mild cognitive impairment or early Alzheimer's and test the next generation of antibodies, tau-targeting drugs and combinations; and symptom studies address agitation, sleep and depression in later stages. Alongside drugs there are trials of exercise, cognitive training, blood tests for diagnosis and support programs for care partners.

In South Carolina, recruiting alzheimer's studies are concentrated in Charleston, Columbia, Summerville and Port Royal. 7 of the 8 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Alzheimer's trials usually look for

Most drug trials enroll ages 50 to 85 and define a stage with a memory test score range, then confirm Alzheimer's with an amyloid PET scan, a spinal fluid test or, increasingly, a blood test, all done by the study. Nearly every trial requires a study partner: someone who knows you well, attends visits and answers questions about daily life. Common exclusions are another cause of memory loss, a recent stroke and, for antibody trials, some blood thinners or MRI findings. Prevention trials enroll people with no symptoms at all.

What taking part involves

Screening is longer than for most conditions, often several visits over a few weeks with memory testing, an MRI and an amyloid test. Antibody trials then involve an infusion or injection every two to four weeks, regular safety MRIs and visits for eighteen months to four years, with an extension in which everyone receives the drug. Lifestyle trials involve classes or coaching for six to twenty-four months. All study care is free and travel is usually reimbursed for you and your partner.

Questions worth asking the study team

Whether you will be told your amyloid or genetic results; what the MRI safety monitoring involves; how much time the study partner must give; whether there is an extension after the placebo period; and what happens if memory worsens during the study.

Showing 8 of 8 recruiting Alzheimer's trials in South Carolina

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
PHASE3 Birmingham, Alabama +4 sites NCT07177352
This trial is looking for individuals who may qualify for Alzheimer's disease research studies. Participants will be assessed to see if they can join related interventional studies.
Recruiting
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
PHASE3 Homewood, Alabama +4 sites NCT05980949
This trial is looking for people who have completed previous studies on KarXT for Alzheimer's-related psychosis. Participants will take KarXT for a year to help researchers understand its long-term safety and tolerability.
Recruiting
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
PHASE3 Homewood, Alabama +4 sites NCT05511363
This trial is looking for older adults with psychosis associated with Alzheimer's Disease. Participants will be randomly assigned to receive either KarXT or a placebo for 38 weeks, with regular visits to monitor their condition.
Recruiting
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
PHASE3 Phoenix, Arizona +4 sites NCT07170150
This trial is looking for people with early symptoms of Alzheimer's disease. Participants will take a medication called trontinemab and go through tests like imaging and assessments to see how well the treatment works and if it is safe.
Recruiting
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
PHASE2 Phoenix, Arizona +4 sites NCT06887192
This trial is looking for men and women aged 55 to 90 who have Alzheimer's disease and are experiencing symptoms like hallucinations or delusions. They need to have been living in the same place for at least six weeks and have a support person who can help track their health. However, it’s important to note that people who are seriously ill, have other major medical issues, or have substance abuse problems can't participate.
Recruiting
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
PHASE3 Scottsdale, Arizona +4 sites NCT07011732
This trial is looking for adults with Alzheimer's disease who experience agitation. Participants will take the study medication and have regular visits to assess their condition.
Recruiting
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
PHASE3 Chandler, Arizona +4 sites NCT06585787
This trial is looking for adults aged 55 to 90 who have been diagnosed with Alzheimer's disease and have experienced troubling symptoms like hallucinations or delusions for at least two months. However, if someone has severe mental health issues like schizophrenia or major depression with psychosis, they won’t be eligible to join. They also need to have had a brain scan in the last five years to ensure there aren’t other serious conditions affecting their symptoms.
Recruiting
Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias
PHASE2 Columbia, South Carolina NCT07638046
This trial is looking for older adults who are at risk of dementia and have a sedentary lifestyle. Participants will take part in walking sessions that include mindfulness training over four weeks.
Recruiting
See all 8 Alzheimer's trials in South Carolina

Where the Alzheimer's studies are in South Carolina

Research sites running the most studies
  • Local Institution - 1035, Charleston2 trials
  • Palmetto Clinical Trials, Summerville2 trials
  • Clinical Site, Port Royal1 trial
  • Local Institution - 1267, Columbia1 trial
  • Local Institution - 1652, Columbia1 trial
  • Ralph H. Johnson VA Medical Center, Charleston1 trial
By city

Counts are recruiting studies listing at least one site in South Carolina, from ClinicalTrials.gov, refreshed every two days.

Alzheimer's clinical trials in South Carolina: common questions

How many Alzheimer's clinical trials are recruiting in South Carolina?
TrialFinder currently lists 8 recruiting Alzheimer's clinical trials with study sites in South Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Alzheimer's clinical trials located in South Carolina?
Study sites for the Alzheimer's trials listed on this page include Columbia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Alzheimer's clinical trial in South Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Alzheimer's trials in South Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Alzheimer's clinical trial in South Carolina?
Each study sets its own criteria based on age, Alzheimer's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need an Alzheimer's diagnosis to join a trial?
No. Prevention trials enroll people with normal memory and test them for early amyloid, and many treatment trials accept people with memory concerns who have not been formally diagnosed, then confirm the diagnosis as part of screening.
What is a study partner?
A family member or close friend who attends visits with you and answers questions about memory and daily activities. Nearly every Alzheimer's trial requires one, and their time is usually reimbursed too.
Will I learn my amyloid or APOE results?
Many trials now disclose amyloid status, since it decides eligibility, and explain what it means. Genetic results are disclosed in some trials and not others; ask before you consent.
Alzheimer's Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Alzheimer's Trials

Alzheimer's disease trials test amyloid-clearing antibodies, tau inhibitors, lifestyle interventions, and early-detection biomarkers for dementia prevention and treatment.

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