Arthritis Trials / Trials in South Carolina
17 Recruiting Trials

Clinical Trials
for Arthritis in South Carolina

17 clinical trials for Arthritis are currently recruiting participants at study sites in South Carolina. Study-related care is provided at no cost.

17
Recruiting trials
20
Study sites
8
Cities
15
Industry-sponsored
7
Phase 2
4
Phase 3

Arthritis clinical trials in South Carolina: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In South Carolina, recruiting arthritis studies are concentrated in Charleston, North Charleston, Summerville and Columbia, with sites in 4 other cities. 15 of the 17 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 17 of 17 recruiting Arthritis trials in South Carolina

Dose Response of Exercise for Arthritis Management
NA Columbia, South Carolina NCT06880653
This trial is looking for adults with certain types of arthritis to test how different amounts of exercise affect their symptoms. Participants will engage in either 45, 90, or 150 minutes of physical activity each week.
Recruiting
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
PHASE3 Birmingham, Alabama +4 sites NCT07219771
This trial is looking for men and women aged 40 to 80 who have knee pain from a condition called osteoarthritis and have had symptoms for at least six months. They need to be able to walk without help, and if they have extra fluid in their knee, that would need to be removed first. If you have severe obesity or pain in your other knee, this might not be the right study for you.
Recruiting
Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain
PHASE3 Roseville, California +4 sites NCT07226258
This trial is looking for adults with chronic knee pain due to osteoarthritis. Participants will receive a single dose of SL1002 to evaluate its effects.
Recruiting
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
PHASE2 Glendale, Arizona +4 sites NCT07276581
This trial is looking for people with moderately-to-severely active rheumatoid arthritis. Participants will be evaluated for how well the medication AZD1163 works and its safety.
Recruiting
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
PHASE2 Peoria, Arizona +4 sites NCT06972446
This trial is looking for patients with rheumatoid arthritis who have not responded to certain treatments. Participants will try new medications and attend regular check-ups to monitor their health.
Recruiting
Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)
PHASE2 Sun City, Arizona +4 sites NCT07486960
This trial is looking for adults with Psoriatic Arthritis who are experiencing active symptoms. Participants will take a study medicine called tulisokibart or a placebo to see if it helps reduce their symptoms better than the placebo.
Recruiting
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
PHASE2 Birmingham, Alabama +4 sites NCT06884865
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Recruiting
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
PHASE1 Peoria, Arizona +4 sites NCT07290036
This trial is looking for adults with active psoriatic arthritis or axial spondyloarthritis. Participants will receive bimekizumab, which can be given in different ways, to see how safe it is and how it moves in the body over time.
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
PHASE2 Birmingham, Alabama +4 sites NCT05986292
This trial is looking for people with chronic pain from conditions like osteoarthritis or diabetic neuropathic pain. Participants will undergo treatments while being monitored for their pain levels.
Recruiting
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
PHASE2 Tuscaloosa, Alabama +4 sites NCT06991114
This trial is looking for adults with certain autoimmune diseases, like rheumatoid arthritis or systemic sclerosis, who haven't responded well to standard treatments. It's important that they've had these conditions diagnosed recently and have tried other medicines without success. People with other serious health issues or who are pregnant may not be able to participate.
Recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
N/A Laguna Woods, California +4 sites NCT05603728
This trial is looking for people who may need shoulder surgery or have had it before. Participants will be followed for at least 10 years to see how well the surgery works over time.
Recruiting
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
N/A Charleston, South Carolina +4 sites NCT07118501
This trial is looking for adults who are having ankle replacement surgery. Participants will share their experience with pain and quality of life after the surgery.
Recruiting
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
N/A Charleston, South Carolina +3 sites NCT07199738
This trial is looking for adults aged 18 to 80 who need knee replacement surgery due to arthritis or related issues. It’s important that your health is stable, so they cannot accept people with certain serious conditions or those who are severely overweight. They also want to exclude anyone who has had recent surgery on the other knee or has specific allergies.
Recruiting
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
N/A Fayetteville, Arkansas +4 sites NCT06040827
This trial is looking for adults who are planning to have total knee replacement surgery due to severe knee pain from osteoarthritis. Participants will be monitored after their surgery to evaluate the treatment's safety and effectiveness.
Recruiting
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
PHASE3 Phoenix, Arizona +4 sites NCT07481630
This trial is looking for adults with knee osteoarthritis and extra body weight. Participants will receive either an injection of NNC0487-0111 or a placebo once a week to see how it helps with weight loss and pain reduction.
Recruiting
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
PHASE2 Birmingham, Alabama +4 sites NCT05658575
This trial is looking for adults with an acute gout flare. Participants will take dapansutrile tablets and help researchers learn about its effects on gout symptoms.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
See all 17 Arthritis trials in South Carolina

Where the Arthritis studies are in South Carolina

Research sites running the most studies
  • Articularis Healthcare Group dba: Low Country Rheumatology ( Site 5128), Summerville1 trial
  • Artiva Investigational Site Charleston, Charleston1 trial
  • Carolina Orthopaedic & Neurosurgical Associates, Spartanburg1 trial
  • Charleston Orthopaedic Associates, Charleston1 trial
  • Clinical Trials of South Carolina - Charleston, Charleston1 trial
  • Clinical Trials of South Carolina - Columbia, Columbia1 trial
By city

Counts are recruiting studies listing at least one site in South Carolina, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in South Carolina: common questions

How many Arthritis clinical trials are recruiting in South Carolina?
TrialFinder currently lists 17 recruiting Arthritis clinical trials with study sites in South Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in South Carolina?
Study sites for the Arthritis trials listed on this page include Columbia, Charleston. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in South Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in South Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in South Carolina?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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