Arthritis Trials / Trials in Wisconsin
11 Recruiting Trials

Clinical Trials
for Arthritis in Wisconsin

11 clinical trials for Arthritis are currently recruiting participants at study sites in Wisconsin. Study-related care is provided at no cost.

11
Recruiting trials
11
Study sites
6
Cities
8
Industry-sponsored
2
Phase 2
1
Phase 3

Arthritis clinical trials in Wisconsin: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Wisconsin, recruiting arthritis studies are concentrated in Glendale, Milwaukee, Madison and Wauwatosa, with sites in 2 other cities. 8 of the 11 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 11 of 11 recruiting Arthritis trials in Wisconsin

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
PHASE3 Glendale, Arizona +4 sites NCT06807424
This trial is looking for people with active psoriatic arthritis who have previously tried certain treatments but still have symptoms. Participants will take part in a study to see how well a medication called icotrokinra works compared to a placebo.
Recruiting
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
PHASE2 Avondale, Arizona +4 sites NCT07137598
This trial is looking for people with moderate to severe rheumatoid arthritis who haven't had good results with previous treatments or can't tolerate them. Participants will receive either the study drug or a placebo to see how it helps with their condition.
Recruiting
An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis
PHASE2 Glendale, Wisconsin +4 sites NCT07620392
This trial is looking for people with moderate to severe rheumatoid arthritis who haven't responded well to certain previous treatments. Participants will have previously taken Afimkibart and will be monitored for their health over time.
Recruiting
Impact of Glucagon-like Peptide-1 (GLP-1) Analogs on Disease Outcomes in Psoriatic Arthritis: A Pragmatic Randomized Controlled Trial
PHASE4 Milwaukee, Wisconsin NCT07111494
This trial is looking for adults with psoriatic arthritis who also need treatment for obesity and type 2 diabetes. Participants will either receive GLP-1 medications or nutrition counseling over a 24-week period while attending the study center for check-ups and filling out questionnaires.
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NA Carmel, Indiana +4 sites NCT05796908
This trial is looking for people with joint pain in the arm caused by unstable radial head issues. Participants will undergo a procedure using the Aptis PRUJ prosthesis and will need to follow post-surgery care guidelines.
Recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
N/A Laguna Woods, California +4 sites NCT05603728
This trial is looking for people who may need shoulder surgery or have had it before. Participants will be followed for at least 10 years to see how well the surgery works over time.
Recruiting
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
N/A Madison, Wisconsin +3 sites NCT07199738
This trial is looking for adults aged 18 to 80 who need knee replacement surgery due to arthritis or related issues. It’s important that your health is stable, so they cannot accept people with certain serious conditions or those who are severely overweight. They also want to exclude anyone who has had recent surgery on the other knee or has specific allergies.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)
PHASE1 Santa Monica, California +4 sites NCT06888193
This trial is looking for mothers who are breastfeeding and are being treated with bimekizumab. Participants will provide breast milk samples to assess the concentration of the treatment in the milk.
Recruiting
Persona Revision Knee System Outcomes
N/A Fayetteville, Arkansas +4 sites NCT04821154
This trial is looking for patients who have had knee surgery and need additional treatment. Participants will be evaluated for the safety and effectiveness of the Persona Revision Knee System.
Recruiting
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
N/A Delafield, Wisconsin NCT04806620
This trial is looking for individuals aged 2 and older with brain inflammation or related health issues, as well as healthy individuals without these conditions. Participants will share health and lifestyle information using an app.
Recruiting
See all 11 Arthritis trials in Wisconsin

Where the Arthritis studies are in Wisconsin

Research sites running the most studies
  • Rheumatic Disease Center, Glendale2 trials
  • Brain Inflammation Collaborative, Delafield1 trial
  • Center of Rheumatic Diseases, Glendale1 trial
  • Children's Hospital Of Wisconsin, Wauwatosa1 trial
  • Medical College of Wisconsin, Milwaukee1 trial
  • Medical College of Wisconsin/Froedtert Hosptial, Milwaukee1 trial
By city

Counts are recruiting studies listing at least one site in Wisconsin, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Wisconsin: common questions

How many Arthritis clinical trials are recruiting in Wisconsin?
TrialFinder currently lists 11 recruiting Arthritis clinical trials with study sites in Wisconsin. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Wisconsin?
Study sites for the Arthritis trials listed on this page include Glendale, Milwaukee, Madison, Delafield. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Wisconsin?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Wisconsin also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Wisconsin?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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