14 Recruiting Trials

Clinical Trials
for Arthritis in Kentucky

14 clinical trials for Arthritis are currently recruiting participants at study sites in Kentucky. Study-related care is provided at no cost.

14
Recruiting trials
14
Study sites
4
Cities
11
Industry-sponsored
3
Phase 2
5
Phase 3

Arthritis clinical trials in Kentucky: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Kentucky, recruiting arthritis studies are concentrated in Lexington, Louisville, Bowling Green and Owensboro. 11 of the 14 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 14 of 14 recruiting Arthritis trials in Kentucky

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
PHASE3 Mobile, Alabama +4 sites NCT07353931
This trial is looking for adults who are at least 50 years old and have knee pain from osteoarthritis, as well as being overweight or obese. It’s important that they haven't had a recent heart issue or surgery for weight loss, and they shouldn’t have diabetes. Participants also need to have tried losing weight through diet without success.
Recruiting
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines
PHASE3 Mesa, Arizona +4 sites NCT06671496
This trial is looking for adults with psoriatic arthritis to test the drug zasocitinib. Participants will receive either zasocitinib or a placebo for up to 60 weeks.
Recruiting
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
PHASE2 Avondale, Arizona +4 sites NCT07137598
This trial is looking for people with moderate to severe rheumatoid arthritis who haven't had good results with previous treatments or can't tolerate them. Participants will receive either the study drug or a placebo to see how it helps with their condition.
Recruiting
Preventing Injured Knees From osteoArthritis: Severity Outcomes
PHASE2 Lexington, Kentucky +4 sites NCT06096259
This trial is looking for people aged 18-45 who have had an ACL injury and are planning to have surgery. Participants will take either metformin or a placebo that looks like metformin to see if it helps reduce pain related to post-traumatic osteoarthritis.
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NA Louisville, Kentucky +4 sites NCT05796908
This trial is looking for people with joint pain in the arm caused by unstable radial head issues. Participants will undergo a procedure using the Aptis PRUJ prosthesis and will need to follow post-surgery care guidelines.
Recruiting
Perform Humeral System Study
N/A Lexington, Kentucky +4 sites NCT05067543
This trial is looking for adults with specific shoulder conditions who are considering shoulder surgery. Participants will help gather information about the safety and effectiveness of a particular device used in surgery.
Recruiting
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
N/A Louisville, Kentucky +4 sites NCT07118501
This trial is looking for adults who are having ankle replacement surgery. Participants will share their experience with pain and quality of life after the surgery.
Recruiting
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
PHASE3 Escondido, California +4 sites NCT07509307
This trial is looking for people with excess weight and knee osteoarthritis. Participants will receive an injection either of the study medicine or a placebo once a week for a set period of time.
Recruiting
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
PHASE3 Birmingham, Alabama +4 sites NCT07339111
This trial is looking for adults with knee cartilage defects and osteoarthritis. Participants will receive either CARTISTEM®, a stem cell treatment, or a surgical procedure to improve knee function and reduce pain.
Recruiting
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
PHASE2 Birmingham, Alabama +4 sites NCT05658575
This trial is looking for adults with an acute gout flare. Participants will take dapansutrile tablets and help researchers learn about its effects on gout symptoms.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
EARLY_PHASE1 Lexington, Kentucky NCT04572256
This trial is looking for patients who are having knee surgery for an ACL injury and have a meniscus tear. Participants will take a daily pill called montelukast or a placebo for 6 months after their surgery.
Recruiting
Zimmer Biomet Shoulder Arthroplasty PMCF
NA Louisville, Kentucky +4 sites NCT04984291
This trial is looking for people who need shoulder replacement surgery due to pain or other shoulder problems. Participants will be monitored for safety and effectiveness of the Zimmer Biomet Shoulder Arthroplasty Systems after the surgery.
Recruiting
Persona Revision Knee System Outcomes
N/A Fayetteville, Arkansas +4 sites NCT04821154
This trial is looking for patients who have had knee surgery and need additional treatment. Participants will be evaluated for the safety and effectiveness of the Persona Revision Knee System.
Recruiting

Where the Arthritis studies are in Kentucky

  • Arthroplasty Foundation Inc., Louisville1 trial
  • Baptist Health Louisville, Louisville1 trial
  • Baptist Healthcare, Lexington1 trial
  • Equity Medical, Owensboro1 trial
  • Graves Gilbert Clinic, Bowling Green1 trial
  • Kleinert Kutz Hand Care Center, Louisville1 trial

Counts are recruiting studies listing at least one site in Kentucky, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Kentucky: common questions

How many Arthritis clinical trials are recruiting in Kentucky?
TrialFinder currently lists 14 recruiting Arthritis clinical trials with study sites in Kentucky. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Kentucky?
Study sites for the Arthritis trials listed on this page include Lexington, Louisville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Kentucky?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Kentucky also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Kentucky?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
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Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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