COVID-19 Trials / Trials in Kentucky
7 Recruiting Trials

Clinical Trials
for COVID-19 in Kentucky

7 clinical trials for COVID-19 are currently recruiting participants at study sites in Kentucky. Study-related care is provided at no cost.

7
Recruiting trials
9
Study sites
3
Cities
4
Industry-sponsored
4
Phase 3

COVID-19 clinical trials in Kentucky: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In Kentucky, recruiting covid-19 studies are concentrated in Louisville, Bardstown and Lexington. 4 of the 7 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 7 of 7 recruiting COVID-19 trials in Kentucky

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 sites NCT06667700
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
NA Lexington, Kentucky +4 sites NCT05218083
This trial is looking for people who have been seriously ill with COVID-19 and are ready to go home from the hospital. Participants will receive support for a physical rehabilitation program that includes exercise sessions monitored through mobile health technology.
Recruiting
A Study of COVID-19 Vaccine(s) in Children and Adults
PHASE3 Bardstown, Kentucky +4 sites NCT07798648
This trial is looking for children and adults who are at risk for serious COVID-19. Participants will receive a COVID-19 vaccine injection and report any side effects over about 6 months.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID
NA Louisville, Kentucky NCT06883513
This trial is looking for people who have experienced Long COVID symptoms for more than 6 weeks since a positive COVID-19 test. Participants will fill out surveys and receive Osteopathic Manipulative Therapy treatments to see if they help improve their symptoms.
Recruiting
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
PHASE3 Birmingham, Alabama +4 sites NCT05624450
This trial is looking for adults who are hospitalized with a viral lung infection and need extra oxygen. Participants will receive treatment with tozorakimab along with their usual care to see if it helps prevent worsening conditions.
Recruiting
See all 7 COVID-19 trials in Kentucky

Where the COVID-19 studies are in Kentucky

Research sites running the most studies
  • Kentucky Pediatric /Adult Research, Bardstown1 trial
  • Research Site, Louisville1 trial
  • UL International Travel Clinic, Louisville1 trial
  • University of Kentucky, Lexington1 trial
  • University of Louisville Hospital, Louisville1 trial
  • University of Louisville Norton Childrens Hospital, Louisville1 trial
By city

Counts are recruiting studies listing at least one site in Kentucky, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in Kentucky: common questions

How many COVID-19 clinical trials are recruiting in Kentucky?
TrialFinder currently lists 7 recruiting COVID-19 clinical trials with study sites in Kentucky. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Kentucky?
Study sites for the COVID-19 trials listed on this page include Lexington, Bardstown, Louisville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Kentucky?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Kentucky also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Kentucky?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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