COVID-19 Trials / Trials in Texas
27 Recruiting Trials

Clinical Trials
for COVID-19 in Texas

27 clinical trials for COVID-19 are currently recruiting participants at study sites in Texas. Study-related care is provided at no cost.

27
Recruiting trials
69
Study sites
27
Cities
12
Industry-sponsored
1
Phase 2
8
Phase 3

COVID-19 clinical trials in Texas: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In Texas, recruiting covid-19 studies are concentrated in Houston, Dallas, Austin and Conroe, with sites in 23 other cities. 12 of the 27 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 20 of 27 recruiting COVID-19 trials in Texas

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 sites NCT06667700
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
PHASE3 Canoga Park, California +4 sites NCT07013474
This trial is looking for adults who are severely immunocompromised and have COVID-19. Participants will receive either ibuzatrelvir alone or with another medication to see how well it works against the virus.
Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 sites NCT05261139
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Recruiting
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
PHASE4 Fair Oaks, California +4 sites NCT07861542
This trial is looking for older adults and younger individuals with health conditions that increase their risk of severe COVID-19. Participants will receive a single injection and have follow-up calls over three months.
Recruiting
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
PHASE1 Anniston, Alabama +4 sites NCT07464314
This trial is looking for healthy adults aged 65 to 85 years who want to help test a new vaccine that combines protection against the flu and COVID-19. Participants will receive different doses of the vaccine or standard vaccines and will be monitored for side effects and immune response.
Recruiting
Vale+Tú Salud: Corner-Based Trial to Test a Latino Day Laborer Program Adapted to Prevent COVID-19
NA Houston, Texas NCT06821113
This trial is looking for Hispanic or Latino day laborers who are looking for work. Participants will help test a program aimed at improving practices to prevent COVID-19, like social distancing and hand-washing.
Recruiting
Well-Being and Health-Related Quality of Life in Melanoma Patients During COVID-19 Pandemic
N/A Houston, Texas NCT04474301
This trial is looking for melanoma patients to understand how the COVID-19 pandemic may have affected their health and quality of life. Participants will complete a 10-minute questionnaire about their experiences during the pandemic.
Recruiting
The Impact of COVID-19 on Pulmonary Procedures
N/A Houston, Texas NCT05022446
This trial is looking for pulmonologists who are members of certain medical associations. Participants will provide information about how their practices changed during the COVID-19 pandemic.
Recruiting
Assessment of the Psychosocial Impact of the COVID-19 Pandemic on the MD Anderson Cancer Center Workforce
N/A Houston, Texas NCT04491292
This trial is looking for employees of MD Anderson Cancer Center to understand how the COVID-19 pandemic has affected their mental health. By participating, employees can help identify ways to support their well-being during this challenging time.
Recruiting
The Effect of COVID-19 Pandemic on Adolescent and Young Adult Cancer Patients and Survivors
N/A Houston, Texas NCT04551378
This trial is looking for young adults aged 15 to 39 who have been diagnosed with cancer. Participants will be asked about their experiences during the COVID-19 pandemic regarding their health and well-being.
Recruiting
Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine
N/A Fort Sam Houston, Texas NCT06402318
This trial is looking for people aged 18 and older who are being screened for COVID-19 at Brooke Army Medical Center. Participants will help test a new breathalyzer device that checks for COVID-19 using breath samples.
Recruiting
A Study of COVID-19 Vaccine(s) in Children and Adults
PHASE3 Homestead, Florida +4 sites NCT07798648
This trial is looking for children and adults who are at risk for serious COVID-19. Participants will receive a COVID-19 vaccine injection and report any side effects over about 6 months.
Recruiting
Clazakizumab vs. Placebo - COVID-19 Infection
PHASE2 Houston, Texas NCT04494724
This trial is looking for adults hospitalized with COVID-19 to see if the drug clazakizumab can help reduce lung damage by blocking inflammation. Participants will receive either the drug or a placebo, which is an inactive substance.
Recruiting
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
PHASE1 Decatur, Georgia +4 sites NCT07536308
This trial is looking for healthy adults aged 18-64 who have already been vaccinated against COVID-19. Participants will receive a single dose of the OCU500 vaccine through either the nose or inhaled method.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
PHASE3 Duarte, California +4 sites NCT03808922
This trial is looking for immunocompromised patients who have a lower respiratory tract infection due to parainfluenza. Participants will receive treatment with DAS181 and need to meet specific health criteria.
Recruiting
A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.
PHASE1 Austin, Texas +1 sites NCT07445971
This trial is looking for healthy adults and adults at higher risk for severe COVID-19 to test a new treatment called MDX2301. Participants will receive doses of MDX2301 or a placebo and will need to attend scheduled visits over the study duration.
Recruiting
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
NA San Antonio, Texas +1 sites NCT05880108
This trial is looking for U.S. Veterans who are obese and have experienced COVID-19 symptoms for at least 4 weeks. Participants will follow a weight loss program that includes diet changes and exercise to see if it helps improve their health and recovery.
Recruiting
A Multi-Site Clinical Evaluation of the LIAISON NES FLU A/B, RSV & COVID-19 Assay in Symptomatic Patients
NA McAllen, Texas +2 sites NCT06672692
This trial is looking for patients with symptoms of respiratory infections like flu or COVID-19. Participants will provide nasal swabs for testing in a lab.
Recruiting
See all 27 COVID-19 trials in Texas

Where the COVID-19 studies are in Texas

Research sites running the most studies
  • M D Anderson Cancer Center, Houston6 trials
  • Houston Methodist Hospital, Houston3 trials
  • The University of Texas Health Science Center at Houston, Houston3 trials
  • Baylor College of Medicine, Houston2 trials
  • UT Physicians, Houston2 trials
  • Zenos Clinical Research, Dallas2 trials
By city

Counts are recruiting studies listing at least one site in Texas, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in Texas: common questions

How many COVID-19 clinical trials are recruiting in Texas?
TrialFinder currently lists 27 recruiting COVID-19 clinical trials with study sites in Texas. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Texas?
Study sites for the COVID-19 trials listed on this page include Houston, Fort Sam Houston, Austin, San Antonio, McAllen. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Texas?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Texas also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Texas?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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