COVID-19 Trials / Trials in New York
21 Recruiting Trials

Clinical Trials
for COVID-19 in New York

21 clinical trials for COVID-19 are currently recruiting participants at study sites in New York. Study-related care is provided at no cost.

21
Recruiting trials
39
Study sites
15
Cities
7
Industry-sponsored
2
Phase 2
9
Phase 3

COVID-19 clinical trials in New York: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In New York, recruiting covid-19 studies are concentrated in New York, Brooklyn, Buffalo and Syracuse, with sites in 11 other cities. 7 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 20 of 21 recruiting COVID-19 trials in New York

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 sites NCT06667700
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
PHASE3 Canoga Park, California +4 sites NCT07013474
This trial is looking for adults who are severely immunocompromised and have COVID-19. Participants will receive either ibuzatrelvir alone or with another medication to see how well it works against the virus.
Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 sites NCT05261139
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Recruiting
Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence
N/A New York, New York NCT04448145
This trial is looking for people who have recovered from COVID-19 and those who have never had it. Participants will provide samples and complete surveys over two years to help understand how the virus behaves after recovery.
Recruiting
ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers
N/A New York, New York NCT04367857
This trial is looking for healthcare workers aged 18 and older to participate in a study about COVID-19 antibodies. Participants will help researchers understand how common COVID-19 is among healthcare workers and how it affects their mental well-being.
Recruiting
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
N/A Brooklyn, New York +2 sites NCT05164744
This trial is looking for people who have survived COVID-19 and had symptoms like difficulty breathing or cough. Participants will undergo heart imaging tests to help understand ongoing heart and lung issues after COVID-19.
Recruiting
Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19
PHASE3 New York, New York NCT06960928
This trial is looking for adults with Long COVID-19. Participants will take either sirolimus or a placebo to see how well it helps with their symptoms.
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
PHASE3 Jacksonville, Florida +4 sites NCT02735707
This trial is looking for adults in intensive care with severe community-acquired pneumonia. Participants will receive various treatments to see what helps them improve.
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
PHASE3 Duarte, California +4 sites NCT03808922
This trial is looking for immunocompromised patients who have a lower respiratory tract infection due to parainfluenza. Participants will receive treatment with DAS181 and need to meet specific health criteria.
Recruiting
SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease
PHASE1 Valhalla, New York +3 sites NCT04896606
This trial is looking for individuals aged 18 to 65 who have mild to moderate COVID-19. Participants will receive a treatment derived from a family member who has recovered from COVID-19.
Recruiting
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
NA New York, New York +4 sites NCT03963622
Recruiting
COVID-19 Survivorship Registry
N/A New York, New York NCT04527315
This trial is looking for people who have recently tested positive for COVID-19, either with or without hospitalization, to learn more about the effects of the virus. Participants will be asked to provide information and may undergo testing to measure lung and heart health.
Recruiting
Long-Covid-19 Alleviation Through Learning Mindfulness Study
NA New York, New York NCT07140094
This trial is looking for adults who have been experiencing Long COVID symptoms. Participants will either start a mindfulness program right away or after 8 weeks, while continuing their regular medical care.
Recruiting
Antiviral Clinical Trial for Long Covid-19
PHASE2 New York, New York NCT06511063
This trial is looking for adults with Long Covid to see if two antiviral medications help reduce their symptoms. Participants will take a daily pill for 90 days and be monitored throughout the study.
Recruiting
Building Community Resilience Program
NA New York, New York NCT06771167
Recruiting
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
PHASE3 Birmingham, Alabama +4 sites NCT05624450
This trial is looking for adults who are hospitalized with a viral lung infection and need extra oxygen. Participants will receive treatment with tozorakimab along with their usual care to see if it helps prevent worsening conditions.
Recruiting
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
PHASE3 Tucson, Arizona +4 sites NCT06631287
This trial is looking for adults with Long COVID symptoms that have lasted at least 6 months. Participants will compare the effects of the medication baricitinib with a placebo on their symptoms and quality of life.
Recruiting
Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers
EARLY_PHASE1 New York, New York NCT04887116
This trial is looking for healthcare workers and COVID-19 patients who have experienced trauma related to their work. Participants will take part in ten virtual reality therapy sessions to help reduce their PTSD symptoms.
Recruiting
General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma
NA New York, New York NCT04626050
This trial is looking for healthcare workers who have experienced trauma related to their jobs. Participants will take part in sessions designed to help with symptoms of PTSD and related issues, using either writing or music therapy initially.
Recruiting
See all 21 COVID-19 trials in New York

Where the COVID-19 studies are in New York

Research sites running the most studies
  • Icahn School of Medicine at Mount Sinai, New York2 trials
  • NYU Langone Health, New York2 trials
  • Weill Cornell Medicine, New York2 trials
  • Advanced Specialty Care, Commack1 trial
  • Cohen Children's Medical Center, New Hyde Park1 trial
  • Columbia University, New York1 trial
By city

Counts are recruiting studies listing at least one site in New York, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in New York: common questions

How many COVID-19 clinical trials are recruiting in New York?
TrialFinder currently lists 21 recruiting COVID-19 clinical trials with study sites in New York. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in New York?
Study sites for the COVID-19 trials listed on this page include New York, Brooklyn, Valhalla. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in New York?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in New York also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in New York?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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