13 Recruiting Trials

Clinical Trials
for Arthritis in Nebraska

13 clinical trials for Arthritis are currently recruiting participants at study sites in Nebraska. Study-related care is provided at no cost.

13
Recruiting trials
8
Study sites
2
Cities
8
Industry-sponsored
5
Phase 2
4
Phase 3

Arthritis clinical trials in Nebraska: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Nebraska, recruiting arthritis studies are concentrated in Omaha and Lincoln. 8 of the 13 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 13 of 13 recruiting Arthritis trials in Nebraska

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
PHASE3 Omaha, Nebraska NCT03414502
This trial is looking for people with rheumatoid arthritis to help find out what predicts how well some medications work. Participants will take a DMARD medication for 16 weeks, and their responses will be monitored.
Recruiting
Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans
PHASE3 Omaha, Nebraska +4 sites NCT06488144
This trial is looking for veterans with knee osteoarthritis who are starting physical therapy. Participants will receive support and encouragement to maintain their exercise routine over two years with follow-up visits.
Recruiting
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
PHASE2 Chandler, Arizona +4 sites NCT07133633
This trial is looking for people with a type of arthritis called radiographic axial spondyloarthritis. Participants will take a medication called tulisokibart to see if it helps improve their symptoms compared to a placebo, which looks like the medication but doesn’t contain any active ingredients.
Recruiting
Preventing Injured Knees From osteoArthritis: Severity Outcomes
PHASE2 Omaha, Nebraska +4 sites NCT06096259
This trial is looking for people aged 18-45 who have had an ACL injury and are planning to have surgery. Participants will take either metformin or a placebo that looks like metformin to see if it helps reduce pain related to post-traumatic osteoarthritis.
Recruiting
Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)
PHASE2 Sun City, Arizona +4 sites NCT07486960
This trial is looking for adults with Psoriatic Arthritis who are experiencing active symptoms. Participants will take a study medicine called tulisokibart or a placebo to see if it helps reduce their symptoms better than the placebo.
Recruiting
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
PHASE2 Birmingham, Alabama +4 sites NCT06884865
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Recruiting
MOTION Clinical Trial
NA Davis, California +4 sites NCT06843980
This trial is looking for people with knee osteoarthritis who have not found relief from other treatments. Participants will compare a new knee treatment to non-surgical options.
Recruiting
Early Rheumatoid Arthritis Lung Disease Study
N/A Omaha, Nebraska NCT03192267
This trial is looking for people with rheumatoid arthritis who are between 19 and 90 years old. Participants will undergo tests to check their lung health and complete some questionnaires.
Recruiting
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
PHASE3 Loxahatchee Groves, Florida +4 sites NCT05669833
This trial is looking for people with psoriatic arthritis who haven't had enough improvement from their current treatment. Participants will switch to one of the two medications being studied to see which works better.
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
PHASE2 Birmingham, Alabama +4 sites NCT05986292
This trial is looking for people with chronic pain from conditions like osteoarthritis or diabetic neuropathic pain. Participants will undergo treatments while being monitored for their pain levels.
Recruiting
Innovations in Genicular Outcomes Registry
N/A Phoenix, Arizona +4 sites NCT05495334
This trial is looking for patients who have knee osteoarthritis and are planning to receive treatments for their pain, such as injections or surgery. Participants will provide information about their experiences and treatments through an app.
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
PHASE1 Anniston, Alabama +4 sites NCT06916806
This trial is looking for adults with Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, or Rheumatoid Arthritis. Participants will receive the study drug AZD5492 either once or twice during the trial period and will attend several check-up visits over at least 180 days.
Recruiting
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
PHASE3 Birmingham, Alabama +4 sites NCT07339111
This trial is looking for adults with knee cartilage defects and osteoarthritis. Participants will receive either CARTISTEM®, a stem cell treatment, or a surgical procedure to improve knee function and reduce pain.
Recruiting

Where the Arthritis studies are in Nebraska

  • University of Nebraska Medical Center, Omaha6 trials
  • Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha1 trial
  • OrthoNebraska Clinics, Omaha1 trial
  • Physician Research Collaboration, LLC ( Site 0057), Lincoln1 trial
  • Physician Research Collaboration, LLC ( Site 5102), Lincoln1 trial
  • Physicians Research Collaboration, Lincoln1 trial

Counts are recruiting studies listing at least one site in Nebraska, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Nebraska: common questions

How many Arthritis clinical trials are recruiting in Nebraska?
TrialFinder currently lists 13 recruiting Arthritis clinical trials with study sites in Nebraska. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Nebraska?
Study sites for the Arthritis trials listed on this page include Omaha. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Nebraska?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Nebraska also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Nebraska?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
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Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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