16 Recruiting Trials

Clinical Trials
for Arthritis in Indiana

16 clinical trials for Arthritis are currently recruiting participants at study sites in Indiana. Study-related care is provided at no cost.

16
Recruiting trials
17
Study sites
7
Cities
13
Industry-sponsored
1
Phase 2
5
Phase 3

Arthritis clinical trials in Indiana: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Indiana, recruiting arthritis studies are concentrated in Indianapolis, Evansville, Carmel and South Bend, with sites in 3 other cities. 13 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 16 of 16 recruiting Arthritis trials in Indiana

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
PHASE3 Mobile, Alabama +4 sites NCT07353931
This trial is looking for adults who are at least 50 years old and have knee pain from osteoarthritis, as well as being overweight or obese. It’s important that they haven't had a recent heart issue or surgery for weight loss, and they shouldn’t have diabetes. Participants also need to have tried losing weight through diet without success.
Recruiting
A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis
PHASE3 Indianapolis, Indiana +4 sites NCT06869551
This trial is looking for children with juvenile psoriatic arthritis who have not had success with previous treatments. Participants will take part in evaluations to help understand the safety and effectiveness of the drug Deucravacitinib.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab
PHASE3 Indianapolis, Indiana +4 sites NCT06100744
This trial is looking for children with juvenile psoriatic arthritis (jPsA). Participants will receive either risankizumab or adalimumab as injections and be monitored for their symptoms and safety over time.
Recruiting
A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
PHASE2 Searcy, Arkansas +4 sites NCT07321873
This trial is looking for adults with active psoriatic arthritis. Participants will take the study drug JNJ-88545223 to see how well it works compared to a placebo.
Recruiting
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
PHASE4 Avondale, Arizona +4 sites NCT06864026
This trial is looking for people with active psoriatic arthritis who are overweight or obese. Participants will add a medication called tirzepatide to their current treatment with ixekizumab for up to 12 months.
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NA Carmel, Indiana +4 sites NCT05796908
This trial is looking for people with joint pain in the arm caused by unstable radial head issues. Participants will undergo a procedure using the Aptis PRUJ prosthesis and will need to follow post-surgery care guidelines.
Recruiting
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
N/A South Bend, Indiana +4 sites NCT07118501
This trial is looking for adults who are having ankle replacement surgery. Participants will share their experience with pain and quality of life after the surgery.
Recruiting
TOUCH® CMC 1 New Enrollment US Study
N/A Indianapolis, Indiana +3 sites NCT07405983
This trial is looking for adults who need surgery for thumb arthritis. Participants will receive a special prosthesis and help evaluate its effectiveness and safety.
Recruiting
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
N/A South Bend, Indiana +4 sites NCT06040827
This trial is looking for adults who are planning to have total knee replacement surgery due to severe knee pain from osteoarthritis. Participants will be monitored after their surgery to evaluate the treatment's safety and effectiveness.
Recruiting
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
PHASE3 Indianapolis, Indiana +4 sites NCT06663332
This trial is looking for children and adolescents with certain types of arthritis or inflammatory bowel disease who have benefited from an earlier treatment with guselkumab. Participants will continue receiving this medication to evaluate its long-term safety.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
The KinematX Midcarpal Total Wrist Arthroplasty Registry
N/A Indianapolis, Indiana +3 sites NCT05719935
This trial is looking for patients who need total wrist replacement surgery using the KinematX implant. Participants will be followed for up to 10 years to track their recovery and wrist function after the surgery.
Recruiting
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
PHASE4 Indianapolis, Indiana NCT06982105
This trial is looking for children aged 60 days to 18 years who have serious infections caused by MRSA. Participants will take either TMP-SMX or clindamycin as part of their treatment and keep track of their symptoms and any side effects.
Recruiting
BioPoly® Partial Resurfacing Knee Implant IDE
NA Fort Wayne, Indiana +3 sites NCT06915363
This trial is looking for adults with knee pain from cartilage damage who may need surgery. Participants will either receive the BioPoly Partial Resurfacing Knee Implant or standard treatment options like microfracture or debridement.
Recruiting
Persona Revision Knee System Outcomes
N/A Evansville, Indiana +4 sites NCT04821154
This trial is looking for patients who have had knee surgery and need additional treatment. Participants will be evaluated for the safety and effectiveness of the Persona Revision Knee System.
Recruiting

Where the Arthritis studies are in Indiana

  • Riley Hospital for Children, Indianapolis2 trials
  • Dupont Hospital, Fort Wayne1 trial
  • Franciscan Health, Indianapolis1 trial
  • Indiana Hand to Shoulder Center, Carmel1 trial
  • Indiana Hand to Shoulder Center, Indianapolis1 trial
  • Indiana University Health, Carmel1 trial

Counts are recruiting studies listing at least one site in Indiana, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Indiana: common questions

How many Arthritis clinical trials are recruiting in Indiana?
TrialFinder currently lists 16 recruiting Arthritis clinical trials with study sites in Indiana. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Indiana?
Study sites for the Arthritis trials listed on this page include Indianapolis, Carmel, South Bend, Fort Wayne, Evansville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Indiana?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Indiana also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Indiana?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
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Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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