Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Recruiting
N/A
Interventional Study
Hypertension
Pure Autonomic Failure
Multiple System Atrophy
Autonomic Failure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 20 (estimated)
- Sponsor
- Vanderbilt University Medical Center · Other
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About This Trial
Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hypotension. The causes of this are not fully understood. The purpose of this study is to evaluate wheth…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg.
* Patients able and willing to provide informed c…
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