No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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You do not need to have the condition being studied to take part.
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At a Glance
Age
15 – 17
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
136 (estimated)
Sponsor
Emory University · Other
Who this trial is looking for
This trial is looking for adolescents with depression who are aged 15-17. Participants will undergo brain scans before, during, and after treatment with Behavioral Activation therapy to study how their brain responds.
Are You a Good Fit for This Trial?
Must not be takingPsychotropic medications
Rules you outBipolar disorderSchizophreniaPsychosisAnorexiaOCDAutism spectrum disorders
You may be able to join if
I am 15-17 years old.
I have been diagnosed with major depressive disorder (MDD).
I have a CDRS-R score above 45.
I can provide treatment as an outpatient.
I have a full-scale IQ above 80.
I have access to a smartphone, tablet, or computer.
I am not taking any other psychosocial treatments.
You may not be able to join if
I have a current or past diagnosis of bipolar disorder or schizophrenia.
I have a current diagnosis of a severe developmental disorder or OCD.
I am currently taking psychotropic medications.
My estimated IQ is below 80.
I have had alcohol or drug dependence in the last 3 months.
I have a history of serious seizures or neurological disorders.
I am pregnant.
I have had a traumatic brain injury.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
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The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance.…
The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging measures.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male and female adolescents ages 15-17;
* current MDD diagnosis as determined by K-SADS-PL,
* CDRS-R raw score \> 45 (T-score \> 65) at baseline;
* estimated full scale IQ \> 80 as determined by the WASI-II;
* able to receive outpatient care;
* willing to not partake in other …
Inclusion Criteria:
* Male and female adolescents ages 15-17;
* current MDD diagnosis as determined by K-SADS-PL,
* CDRS-R raw score \> 45 (T-score \> 65) at baseline;
* estimated full scale IQ \> 80 as determined by the WASI-II;
* able to receive outpatient care;
* willing to not partake in other psychosocial treatments;
* not taking psychotropic medications in the two weeks (four weeks for fluoxetine) prior to consent, with the exception of psychostimulant medication prescribed for the treatment of ADHD.
* Additionally, depressed patients must have access to required technology (e.g. smart phone, tablet, or desktop computer) to complete the EMA portion of the study.
* Healthy controls cannot not meet criteria for MDD and their CDRS-R raw score must be below 28; T-score \< 52).
Exclusion Criteria:
* Current or past diagnosis of bipolar, schizophrenia, schizophreniform, schizoaffective disorders, or psychosis NOS;
* current diagnosis of developmental disorder, severe conduct disorder, life-threatening anorexia, OCD, or autism-spectrum disorders;
* taking psychotropic medications prior to entry;
* estimated IQ \< 80; alcohol/drug dependence or abuse within the last 3 months;
* potential/confirmed neurological disorder or epilepsy;
* claustrophobia;
* presence of a medical condition that precludes fMRI;
* endorsement of imminent and serious suicidality;
* medical conditions that take precedence over the presence of MDD;
* pregnancy;
* substance use (excluding nicotine) within two weeks of the fMRI scan;
* left-handedness;
* nicotine use within 3 hours of the fMRI scan;
* history of traumatic brain injury or of being unconscious for more than 30 minutes;
* a stimulant regime for ADHD which has changed within 30 days of the fMRI scan.
* Non-compliance (i.e. \<70% completion) or inability (i.e. lack of smartphone device) to complete the 3 assessment periods of EMA.
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