No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Supportive Care
Participants needed
100 (estimated)
Sponsor
Indiana University · Other
Who this trial is looking for
This trial is looking for people with metastatic breast cancer who have not seen their disease worsen in the last year. Participants will take part in a 16-week exercise program that includes aerobic and strength training.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years or older.
I have been diagnosed with metastatic breast cancer.
My disease has not progressed in the last 12 months.
I can walk on a treadmill without help.
I do not meet physical activity guidelines.
I have a cellular device that works with iOS 15 or Android 7.
You may not be able to join if
I have received chemotherapy in the last 12 months.
I have uncontrolled heart issues.
I have had a heart attack in the last 12 months.
I have had orthopedic surgery in the last 3 months.
I have uncontrolled breathing problems.
I have active, untreated brain metastases.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness,…
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness, functional status, and sarcopenia (low muscle mass), all established predictors of survival, and 2) patient- reported outcomes.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Age ≥ 18 years
2. Diagnosis of metastatic breast cancer
3. No progression of disease in the 12 months prior to screening per the treating investigator
1. If participant has changed treatments in the prior 12 months for reasons other than progressive disease, they remain e…
Inclusion Criteria:
1. Age ≥ 18 years
2. Diagnosis of metastatic breast cancer
3. No progression of disease in the 12 months prior to screening per the treating investigator
1. If participant has changed treatments in the prior 12 months for reasons other than progressive disease, they remain eligible
2. Participants on no treatment or "no evidence of disease" but still with a diagnosis of metastatic breast cancer are eligible
4. ECOG performance status of 0-2
5. Ability to walk on a treadmill without assistive device.
6. Informed consent and authorization of the release of health information must be obtained according to institutional guidelines
7. Currently not meeting physical activity guidelines (defined as less than 150 minutes of moderate to vigorous exercise per week measured by the IPAQ questionnaire administered during screening)
8. Participants should have a cellular device compatible with iOS 15 or Android operating system 7.
Exclusion Criteria:
1. Receiving cytotoxic chemotherapy at any point in the prior 12 months.
1. Participants receiving endocrine therapy are eligible.
2. Participants receiving targeted therapy or antibody therapy are eligible (examples including trastuzumab, pertuzumab, TDM-1, trastuzumab deruxtecan, sacituzumab govetecan, immunotherapy, CDK4/6 inhibitors, olaparib, alpelisib, etc.)
2. Any condition precluding supervised exercise participation. A letter from a physician supporting participation can supersede this eligibility criteria.
* NYHA class III or IV congestive heart failure
* Uncontrolled angina
* Myocardial infarction in the prior 12 months
* Orthopedic surgery in the previous 3 months or plans for orthopedic surgery during the study period
* Chronic uncontrolled pulmonary conditions such as uncontrolled asthma (symptoms \> 2 days/week) or dyspnea requiring oxygen
* Symptomatic peripheral vascular disease
* Or any other comorbidity that would interfere with the ability to complete and comply with the protocol in the opinion of the investigator, including psychological illness
* History of fragility fracture
3. Active, untreated brain metastases
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