No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
1,000 (estimated)
Sponsor
Cedars-Sinai Medical Center · Other
Who this trial is looking for
This trial is looking for people with Multiple Sclerosis or related conditions. Participants will be involved in assessments using visual tests and MRI scans to help understand disability progression.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Multiple Sclerosis or a related condition.
I am at least 18 years old.
I can give informed consent.
You may not be able to join if
I cannot have an MRI due to metal implants or other reasons.
I am pregnant.
I have had recent eye surgery in the past two months.
I have significant refractive errors or other eye diseases.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in qu…
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Subjects who meet any one of the following diagnostic criteria:
* Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
* Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
* Diagnosis of myelin oligodendrocyte glycoprot…
Inclusion Criteria:
* Subjects who meet any one of the following diagnostic criteria:
* Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
* Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
* Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
* Diagnosis of neurological disorders other than MSRD.
* Healthy volunteer.
* Age ≥18.
* Able to give informed consent.
Exclusion Criteria:
* Patients will be excluded from the MRI portions of the study if they have a contraindication to MRI(metallic implantsor foreign bodies, claustrophobia, MRI-incompatible pacemakers, MRI- incompatible prosthetic heart valves).
* Patients will be excluded from the MRI portions of the study if they are pregnant, but their demographic, clinical information,and disability measures may still be captured under the study.
* Patients will be excluded from the visual assessment portions of the study if they have had any recent ocular surgery (within the past two months), refractive errors of greater than or equal to ±6 diopters or other eye diseases that may affect or confound OCT/OCTA measurements (ex., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma).
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