No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
45 – 85
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
65 (estimated)
Sponsor
University of Southern California · Other
Who this trial is looking for
This trial is looking for older adults who have experienced a stroke more than six months ago. Participants will help researchers understand how thinking skills affect walking abilities after a stroke.
Are You a Good Fit for This Trial?
You may be able to join if
I have had a stroke more than 6 months ago.
I have weakness on one side of my body.
I can walk for 5 minutes without stopping.
I am willing to complete study procedures.
You may not be able to join if
I have a stroke in the brainstem or cerebellum.
I have problems with speaking or understanding language.
I have a major health issue that affects my movement or thinking.
I have metal in my head (except in my mouth) or medical devices that are not safe for MRI.
I have high blood pressure not controlled by medication.
I am currently receiving physical therapy.
I have difficulty being in tight spaces.
I have significant memory problems or dementia.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairmen…
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Unilateral stroke
* Stroke occurred more than 6 months prior
* Paresis confined to one side
* Independently ambulatory (including the use of assistive devices)
* Able to walk for 5 minutes without stopping
* Answers no to all general health questions on the PAR-Q+
* Willingnes…
Inclusion Criteria:
* Unilateral stroke
* Stroke occurred more than 6 months prior
* Paresis confined to one side
* Independently ambulatory (including the use of assistive devices)
* Able to walk for 5 minutes without stopping
* Answers no to all general health questions on the PAR-Q+
* Willingness to complete study procedures
Exclusion Criteria:
* Brainstem or cerebellar stroke
* Aphasia (expressive, receptive, or global)
* Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
* Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
* Uncontrolled hypertension (\>160/110mmHg)
* Concurrent physical therapy
* Claustrophobia
* Significant cognitive deficit or dementia (\<20 on MoCA)
* Inability to give informed consent
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