Brain Stimulation for Anxiety and Depression

Decoding and Modulating Affective Brain States

Recruiting N/A Interventional Study
Rumination Major Depressive Disorder Anxiety
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
40 (estimated)
Sponsor
University of Pennsylvania · Other
Who this trial is looking for

This trial is looking for adults aged 18-65 who experience anxiety or depression. Participants will undergo brain imaging and receive brain stimulation to see if it helps reduce negative emotions.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 18 and 65 years old.
  • I have a Patient Health Questionnaire (PHQ-9) score of 10 or higher.
  • I can understand instructions in English.
  • I can provide informed consent and follow study procedures.
  • I am available for the duration of the study.

You may not be able to join if

  • I have been diagnosed with bipolar disorder, schizophrenia, or another psychotic disorder.
  • I have recently used psychoactive medications or substances.
  • I have a history of neurological disorder or traumatic brain injury (except mild).
  • I cannot have an MRI scan due to medical reasons.
  • I cannot receive or tolerate transcranial magnetic stimulation (TMS).
  • I have implanted devices like an aneurysm clip or cardiac pacemaker.
  • I have a history of stroke, epilepsy, or brain scarring.
  • I am pregnant, nursing, or trying to become pregnant.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repet…
Trial Locations
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Eligibility Criteria
Inclusion criteria: 1. 18-65 years old 2. Patient Health Questionnaire (PHQ-9 score) = or \> than 10 3. Comprehension of instructions in the English language. 4. Capacity to provide informed consent and follow study procedures. 5. Availability for the duration of the study. Exclusion Criteria: 1.…
Contacts

Camille Blaine

215-573-0828

camille.blaine@pennmedicine.upenn.edu

CONTACT

Almaris Figueroa-Gonzalez

215-746-6751

almaris.figueroa-gonzalez@pennmedicine.upenn.edu

CONTACT