No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
40 (estimated)
Sponsor
University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for adults aged 18-65 who experience anxiety or depression. Participants will undergo brain imaging and receive brain stimulation to see if it helps reduce negative emotions.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 65 years old.
I have a Patient Health Questionnaire (PHQ-9) score of 10 or higher.
I can understand instructions in English.
I can provide informed consent and follow study procedures.
I am available for the duration of the study.
You may not be able to join if
I have been diagnosed with bipolar disorder, schizophrenia, or another psychotic disorder.
I have recently used psychoactive medications or substances.
I have a history of neurological disorder or traumatic brain injury (except mild).
I cannot have an MRI scan due to medical reasons.
I cannot receive or tolerate transcranial magnetic stimulation (TMS).
I have implanted devices like an aneurysm clip or cardiac pacemaker.
I have a history of stroke, epilepsy, or brain scarring.
I am pregnant, nursing, or trying to become pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repet…
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion criteria:
1. 18-65 years old
2. Patient Health Questionnaire (PHQ-9 score) = or \> than 10
3. Comprehension of instructions in the English language.
4. Capacity to provide informed consent and follow study procedures.
5. Availability for the duration of the study.
Exclusion Criteria:
1.…
Inclusion criteria:
1. 18-65 years old
2. Patient Health Questionnaire (PHQ-9 score) = or \> than 10
3. Comprehension of instructions in the English language.
4. Capacity to provide informed consent and follow study procedures.
5. Availability for the duration of the study.
Exclusion Criteria:
1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
2. Recent use of psychoactive medications or substances as determined by investigators
3. History of neurological disorder or traumatic brain injury (other than mild)
4. Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
5. Unable to receive or tolerate TMS
6. Implanted devices, such as an aneurysm clip or cardiac pacemaker
7. History of stroke, epilepsy, or brain scarring
8. Pregnant, nursing, or trying to become pregnant (self-attestation alone)
During this study, participants are asked to:
1. Refrain from substance use (including marijuana and illicit drugs) for duration of the study (self-attestation alone).
2. Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).
3. Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.